Social support and physical literacy in young and middle-aged patients with hypertension: the mediating effects of sense of coherence and self-efficacy.

BACKGROUND: Despite the growing recognition of the importance of social support and physical literacy in managing hypertension among young and middle-aged patients, there is a lack of research exploring the mediating effects of sense of coherence and self-efficacy in this relationship. This study aims to bridge this gap by investigating the interplay between social support, physical literacy, sense of coherence, and self-efficacy, thus contributing to a deeper understanding of effective interventions for hypertension management. METHODS: A cross-sectional study was conducted using convenience sampling to survey 280 young and middle-aged patients diagnosed with hypertension from five community settings in Zhejiang and Anhui provinces between January and February 2024. Measurement instruments included the General Information Questionnaire, Physical Literacy Scale for Young and Middle-aged Patients with Hypertension, Sense of Coherence Scale 13, General self-efficacy Scale, and Perception Social Support Scale. Data analysis was performed using SPSS 27.0 and AMOS 28.0, with reporting following the STROBE checklist. RESULTS: A total of 270 valid questionnaires were collected. The total score of physical literacy for young and middle-aged patients with hypertension ranged from 18 to 90, with a mean score of 62.30 ± 13.92, indicating a moderate level. There was a positive correlation between the physical literacy score and the scores of social support (r = 0.557, P<0.01), sense of coherence (r = 0.392, P<0.01), and self-efficacy (r = 0.466, P<0.01) among young and middle-aged patients with hypertension. Furthermore, social support was found to have multiple mediating effects through sense of coherence and self-efficacy on physical literacy. CONCLUSION: This study sheds light on the interconnectedness of social support, physical literacy, sense of coherence, and self-efficacy among young and middle-aged patients with hypertension. The findings underscore the importance of considering these factors holistically in hypertension management strategies.

The native submerged plant, Hydrilla verticillata outperforms its exotic confamilial with exposure to polyamide microplastic pollution: Implication for wetland revegetation and potential driving mechanism.

Microplastic pollution and biological invasion, as two by-products of human civilization, interfere the ecological function of aquatic ecosystem. The restoration of aquatic vegetation has been considered a practical approach to offset the deterioration of aquatic ecosystem. However, a lack of knowledge still lies in the species selection in the revegetation when confronting the interference from microplastic pollution and exotic counterpart. The present study subjected the native submerged species, Hydrilla verticillata and its exotic confamilial, Elodea nuttallii to the current and future scenarios of polyamide microplastic pollution. The plant performance proxies including biomass and ramet number were measured. We found that the native H. verticillata maintained its performance while the exotic E. nuttallii showed decreases in biomass and ramet number under severest pollution conditions. The restoration of native submerged plant such as H. verticillata appeared to be more effective in stabilizing aquatic vegetation in the scenario of accelerating microplastic pollution. In order to explore the underlying driving mechanism of performance differentiation, stress tolerance indicators for plants, sediment enzymatic activity and sediment fungal microbiome were investigated. We found that polyamide microplastic had weak effects on stress tolerance indicators for plants, sediment enzymatic activity and sediment fungal diversity, reflecting the decoupling between these indicators and plant performance. However, the relative abundance of sediment arbuscular mycorrhizal fungi for H. verticillata significantly increased while E. nuttallii gathered "useless" ectomycorrhizal fungi at the presence of severest polyamide microplastic pollution. We speculate that the arbuscular mycorrhizal fungi assisted the stabilization of plant performance for H. verticillata with exposure to the severest polyamide microplastic pollution.

Improving cell reinfusion to enhance the efficacy of chimeric antigen receptor T-cell therapy and alleviate complications.

Adoptive cell therapy (ACT) is a rapidly expanding area within the realm of transfusion medicine, focusing on the delivery of lymphocytes to trigger responses against tumors, viruses, or inflammation. This area has quickly evolved from its initial promise in immuno-oncology during preclinical trials to commercial approval of chimeric antigen receptor (CAR) T-cell therapies for leukemia and lymphoma (Jun and et al., 2018) [1]. CAR T-cell therapy has demonstrated success in treating hematological malignancies, particularly relapsed/refractory B-cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma (Qi and et al., 2022) [2]. However, its success in treating solid tumors faces challenges due to the short-lived presence of CAR-T cells in the body and diminished T cell functionality (Majzner and Mackall, 2019) [3]. CAR T-cell therapy functions by activating immune effector cells, yet significant side effects and short response durations remain considerable obstacles to its advancement. A prior study demonstrated that the therapeutic regimen can induce systemic inflammatory reactions, such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), tumor lysis syndrome (TLS), off-target effects, and other severe complications. This study aims to explore current research frontiers in this area.

Factors influencing self-quantification for patients with hypertension: A cross-sectional Study.

This study aimed to investigate the level of self-quantification among patients with hypertension and identify the factors influencing this behavior. This study aimed to investigate self-quantification levels and identify influencing factors among 400 patients diagnosed with hypertension. Employing a convenience sampling method, the research was conducted across diverse healthcare settings, including a tertiary hospital, 2 community hospitals, 2 pension institutions, and 5 residential areas. Participants underwent assessment using a self-quantification scale. The collected data underwent thorough analysis using various statistical methods, including descriptive analysis for an overview, 2 independent samples t test for mean comparisons, one-way analysis of variance for variations among groups, and multiple linear regression analysis to identify influential factors. This robust methodology was applied to gain comprehensive insights into the self-quantification behaviors of patients with hypertension. The total self-quantification score for patients with hypertension was found to be (96.64 ±â€…14.16). The average value for all dimensions was (3.22 ± 0.47). Notably, medical insurance type, education level, age, and complications were identified as significant factors influencing self-quantification among patients with hypertension. The study concludes that patients without medical insurance, with lower education levels, older age, and no complications tended to have lower levels of self-quantification. These findings underscore the necessity for targeted interventions to improve self-quantification in these specific patient groups. By addressing the identified influencing factors, healthcare providers can implement measures to enhance self-quantification among patients with hypertension.

Music Intervention for older adults: Evidence Map of Systematic Reviews.

BACKGROUND: With the increasing aging population, the health problems of the elderly have received increasing attention. As a non-pharmacological interventions, music intervention has been widely used in clinical practice to improve the physical and mental health of the elderly. This article aims to provide a comprehensive review of existing systematic reviews on the health effects of music interventions for older adults in clinical practice. METHODS: The study utilized the evidence map methodology, which involved identifying all relevant systematic reviews, meta-analysis from 7 electronic databases from their inception to November 2022. The studies were analyzed using AMSTAR 2. RESULTS: The researchers identified 67 studies, with the majority published in the past 5 years. The effects of music interventions were categorized into 4 groups of health outcomes: positive (58 results), potentially positive (4 results), inconclusive (2 results), and no effect (3 results). The health outcomes were further classified into 5 groups: psychological well-being, cognitive functioning, physiological responses, quality of life, and overall well-being. CONCLUSIONS: The study revealed that music interventions for older adults can have positive or potentially positive effects on health outcomes, encompassing psychological well-being, cognitive functioning, physiological responses, quality of life, and overall well-being. However, some studies yielded inconclusive or no effect. The study offers valuable insights for healthcare professionals and serves as a visual resource to access evidence-based information on the use of music interventions in promoting health and addressing various conditions in older adults.

Core self-evaluation and innovative behavior: mediating effect of error orientation and self-efficacy of nurses.

Background: Innovation plays a crucial role in advancing nursing and healthcare. Despite its significance, there is a paucity of research examining the interplay among nursing innovative behavior, core self-evaluation, error orientation, and self-efficacy. This study, grounded in Bandura's social cognitive theory, seeks to not only investigate the influence of core self-evaluation on nurses' innovative behavior but also to elucidate the mediating roles of error orientation and self-efficacy within this relationship. By addressing these dynamics, the research aims to provide a comprehensive understanding of the factors shaping nurses' innovative behaviors and contribute to the broader discourse on enhancing healthcare practices. Design: A cross-sectional study using an online questionnaire. Setting: Participants were recruited from 23 hospitals in 6 provinces and 1 municipality directly under the central government in China, namely Zhejiang, Anhui, Jiangxi, Guangdong, Hebei, Henan, and Shanghai. Participants: A total of 741 nurses enrolled in the study. Methods: The participants completed the nurse innovative behavior scale, the core self-evaluation scale, the error orientation questionnaire, and the self-efficacy scale online in 2023. SPSS and AMOS were used for data analysis. The reporting followed the STROBE checklist. Results: A total of 706 valid questionnaires were collected. A positive core self-evaluation was associated with more innovative behavior, and this relation was partially mediated by error orientation and self-efficacy to avoid failure. Core self-evaluation, error orientation and self-efficacy of nurses had a positive predictive effect on innovation behavior, with the path coefficients at 0.09, 0.23, and 0.39, respectively. Conclusion: Our study complements the evidence on the mechanism of action between the core self-evaluation and innovative behavior. Our findings have important clinical implications for promoting innovative behavior in nurses.

Status of knowledge, attitude, and practice of SARS-CoV-2 vaccine inoculation among college students and the influencing factors. / å¤§å­¦ç”Ÿæ–°å† ç— æ¯’ç–«è‹—æŽ¥ç§çŸ¥ä¿¡è¡ŒçŽ°çŠ¶åŠå½±å“å› ç´ .

OBJECTIVES: During the outbreak of coronavirus disease 2019 (COVID-19), vaccine is an important way to build and improve the immune barrier of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in the population. The purpose of this study is to understand the current situation of knowledge, attitude, and practice (KAP) of SARS-CoV-2 vaccine inoculation among Chinese college students during the epidemic of COVID-19, and analyze the influencing factors. METHODS: Using the convenient sampling method, we selected the college students from a comprehensive university in Hunan Province in May 2021 and designed KAP questionnaire about SARS-CoV-2 vaccine inoculation for offline and online survey to analyze the current situation of college students' KAP of SARS-CoV-2 vaccine inoculation and the influenting factors. RESULTS: The total score of KAP of SARS-CoV-2 vaccine inoculation of Chinese college students was 43.72±5.60. The total score of knowledge was 16.28 ±3.09, and the score of each item was 3.26±0.62. The correct rate of the 5 questions in knowledge was 80.34%, 93.18%, 94.64%, 99.60% and 39.18%, respectively. The total score of attitude was 13.56±2.39, and the score of each item was 3.39±0.60. The total score of behavior was 13.88±2.51, and the score of each item was 3.47±0.63. The total scores of better health status, girls, and medical majors were relatively higher; those of medical majors, older students, and girls had higher scores on vaccination knowledge; those with better health and younger age had higher scores on attitude; those of better health status and girls had higher behavior scores (all P<0.05). CONCLUSIONS: College students' KAP about SARS-CoV-2 vaccine inoculation is generally high, but the knowledge level is relatively low. We should strengthen the propaganda and education for SARS-CoV-2 vaccine inoculation related knowledge, and strengthen the SARS-CoV-2 vaccine inoculation attitude and behavior of college students. Special attention should be paid to the education of vaccination knowledge for non-medical majors, younger, and male students, the guidance of vaccination attitude for those with poor health and older age, and encouragement of vaccination behavior for those with poor health and boys.

Development and Validation of a Self-Quantification Scale for Patients With Hypertension.

Background: The self-management ability of patients with hypertension is poor, and self-quantification increases gradually with the development of electronics. Self-quantification for patients with hypertension has important implications for individual health. However, there is a lack of relevant scales at present, and we aim to develop a self-quantified scale for patients with hypertension. Methods: The instrument was developed based on protection motivation theory with literature review, a qualitative interview study and focus group discussions, and pilot testing. A total of 360 patients with hypertension were investigated using the scale. The psychometric properties of the scale were evaluated concerning validity and reliability employing internal consistency reliability, split-half reliability, test-retest reliability, content validity (S-CVI/Ave and I-CVI), and construct validity (exploratory factor analysis and confirmatory factor analysis). Results: The final scale had 30 items with seven sub-domains. The Cronbach's α for all domains was 0.900 with a range of 0.817-0.938. The split-half reliability coefficient for all domains was 0.743 with a range of 0.700-0.888. The test-retest reliability coefficient for all domains was 0.880 with a range of 0.849-0.943. The S-CVI/Ave for all domains was 0.922 with a range of 0.906- 0.950, and the I-CVI of each item was a range of 0.800-1.000. The result of confirmatory factor analysis of this scale showed that χ2/df was 2.499, RMSEA = 0.065, GFI=0.865, NFI=0.894, IFI=0.934, TLI=0.914, CFI=0.933, RFI=0.865. The Pearson's coefficients between the total scale and every domain were ranging from 0.347 to 0.695, and each domain ranged from 0.130 to 0.481. Conclusion: The scale has good validity and reliability and can be used as a self-quantification scale for patients with hypertension.

Social Media Use, eHealth Literacy, Knowledge, Attitudes, and Practices Toward COVID-19 Vaccination Among Chinese College Students in the Phase of Regular Epidemic Prevention and Control: A Cross-Sectional Survey.

BACKGROUND: College students are at a high risk of being infected with COVID-19, and they are one of the key population clusters that should be vaccinated. The present study aimed to investigate the knowledge, attitudes, and practices (KAP) toward COVID-19 vaccination among Chinese college students, and to determine the relationships among social media use, eHealth literacy, and KAP toward COVID-19 vaccination among Chinese college students. METHODS: A cross-sectional survey was conducted by administering questionnaires to evaluate KAP toward COVID-19 vaccination, social media use, and eHealth literacy in one of the groups of Chinese college students. Multiple linear regression analysis was performed to determine the association among social media use, eHealth literacy, and KAP regarding COVID-19 vaccination. RESULTS: Among the 3,785 validated questionnaires collected from Chinese college students, male students accounted for 59.74%, and the mean age of the college students was (20.90 ± 3.14) years. More than four-fifths (83.43%) of the college students spent <2 h a week on social media, and the official and public social media were most common social media types. Additionally, the scores for KAP toward COVID-19 vaccination ranging from 0 to 48 among college students were high (39.73 ± 5.58), lowest for knowledge domain (3.07 ± 0.76), and the highest for practice domain (3.47 ± 0.63). Female college students who were in good health status and who spent more time browsing social media, frequently used official and public social media, rarely used aggregated social media, and had a relatively strong self-perception of eHealth literacy and information acquisition of eHealth literacy were more likely to have high levels of KAP regarding COVID-19 vaccination. CONCLUSIONS: Overall, Chinese college students have excellent KAP toward COVID-19 vaccination. Based on the findings of this study, we recommend that health counseling regarding COVID-19 vaccination should target male students and those with inferior health status. Dissemination of health education regarding COVID-19 vaccination should be purposely conducted, and cooperation with official and public social media platforms should be promoted. Finally, eHealth literacy, which is one of the predictors of the level of KAP regarding COVID-19 vaccination, should be emphasized.

Associations of COVID-19 Risk Perception, eHealth Literacy, and Protective Behaviors Among Chinese College Students Following Vaccination: A Cross-Sectional Study.

BACKGROUND: In spite of strict regulation of coronavirus disease 2019 (COVID-19) preventive measures and containment in China, there are still confirmed cases sporadically occurring in many cities. College students live in groups and have active social activities so that it will trigger a serious public health event once an infection event occurs. Thus, identifying the status and related factors of protective behaviors among them after receiving vaccination will be crucial for epidemic control. This study aimed to gather information on the protective behaviors and to identify the associations of COVID-19 risk perception, eHealth literacy, and protective behaviors for Chinese college students following vaccination. METHODS: A cross-sectional survey of college students engaged in protective behaviors post vaccination was conducted using the COVID-19 risk perception scale, eHealth literacy scale, and protective behaviors following vaccination questionnaire in one of the groups. Multiple linear regression analysis was used to confirm the correlation among the COVID-19 risk perception, eHealth literacy, and protective behaviors for Chinese college students. RESULTS: A total of 5,641 Chinese college students were included. Male students comprised 59.01% with an average age of (21.39 ± 2.75) years and most students rating their health as very good (44.85%) or pretty good (46.98%). A smaller percentage (13.76%) believed that they would likely or most likely be infected with COVID-19 after getting vaccinated. In addition, more than 1 in 10 (10.35%) college students had ever suspected to suffer from post-vaccination reactions following the COVID-19 vaccination. The mean score of protective behaviors was 26.06 ± 3.97. Approximately one-third (30.42%) of the students always or often did not wear a mask when going out. Some college students (29.25%) did not maintain distance of at least 1 m from others in social situations. Older female college students who were in good health and perceived as being at a low risk of getting infected with COVID-19, and those never suspected to suffer from post-vaccination reactions expected to engage in post-vaccination protective measures. Those with a higher level of perceived risk, severe risk perception and eHealth literacy, and a lower level of unknown risk perception were more likely to engage in further protective behaviors after getting vaccinated. CONCLUSIONS: Overall, the level of protective behaviors among the Chinese college students following vaccination could be improved, especially for male, younger college students in poor health. This study revealed the predictive effects of risk perception and eHealth literacy on protective behaviors, recommending that the negative and positive effects of risk perception should be balanced in epidemic risk management, and eHealth literacy promotion should also be emphasized for public health and social measures.

The status of medication literacy and associated factors of hypertensive patients in China: a cross-sectional study.

The adverse consequence of low medication literacy is a major problem that threatens patients' health. The number of people with hypertension is increasing in China. We described the current situation of medication literacy of patients with hypertension in China and its related influencing factor. We conducted a cross-sectional study, which contains 590 hypertensive patients. Stratified sampling was adopted according to the hospital level in China. To determine the factors related to medication literacy, multiple linear regression analysis was used to determine associations between medication literacy of hypertensive patients and other factors. Among 590 respondents, results showed that they have poor medication literacy. Multiple linear regression analysis showed that level of education, annual income, occupation status, and type of medical insurance were significantly associated with medication literacy level of hypertensive patients. In addition, our study also demonstrates that we can identify the medication literacy level of hypertensive patients using the Chinese version Medication Literacy Scale for Hypertensive Patients. High medication literacy is an important factor for hypertensive patients to improve medication adherence, so as to better control blood pressure. We should pay attention to the improvement of medication literacy and take corresponding measures.

Medication Literacy in a Cohort of Chinese Patients Discharged With Essential Hypertension.

Background: In recent years, research on medication literacy has increased in many countries. Medication literacy in patients with essential hypertension affects the management and prognosis of hypertension. Method: This is a cross-sectional study of 147 discharged patients with essential hypertension who were treated at a tertiary hospital in Changsha, Hunan, China, between March and June 2016. The demographic and clinical data of the patients with hypertension were obtained from the medical records. The Chinese version of the Medication Literacy Questionnaire was applied to measure the medication literacy of hypertensive patients from 7 to 30 days after discharge by structured interview. Data were analyzed using SPSS version 19.0. Multiple linear regression was used to analyse the meaningful determinants of medication literacy. Results: The medication literacy of discharged patients with hypertension was poor. More than 70% of patients had no substantial knowledge of the effects and side effects of the medications they were taking, more than 30% of patients did not know the name or dose of the medication, and more than 20% of patients did not know how often to take the medication. Conclusion: It is necessary to conduct targeted health education for discharged patients with essential hypertension to reduce the risks of low medication literacy based on the determinants obtained in this study.