Associations of type 2 diabetes and the risk of migraine in Chinese populations.

AIM: We aimed to explore the relationship between type 2 diabetes mellitus (T2DM) and the incidence rate of migraine in a Chinese population, and analyze the clinical characteristics of migraine patients with T2DM. METHODS: Data on the study cohort of 9873 individuals were obtained from the China Health and Retirement Longitudinal Study (CHARLS). The incidence rate of migraine from 2015 to 2018 was assessed. The Cox proportional hazards model was used to estimate hazard ratios (HRs) and their 95% confidence intervals (CIs) for the relationship between T2DM and the incidence of migraine. In addition, a cross-sectional study including 168 migraine patients was conducted in Xiamen, China. Migraine patients were grouped according to their T2DM status. Multivariable linear regression models were used to estimate ßs and their 95% CIs for the relationship between migraine characteristics and T2DM. RESULTS: The cumulative incidence rate of migraine from 2015 to 2018 in the T2DM group and control group was 7.26% [6.04%.8.65%] and 8.91% [8.27%.9.58%], respectively. The risk of migraine in patients with T2DM was reduced by 21% (HR 0.79 [0.65;0.95]) compared to patients with no T2DM after adjustment for confounders. The cross-sectional study showed that the presence of T2DM significantly reduced migraine frequency and relieved migraine intensity. CONCLUSION: This was the first study to validate that T2DM reduced the risk of migraine in a Chinese population cohort. Patients with migraine and T2DM may experience significant relief from their headache symptoms. Carrying out relevant mechanistic research may help to identify new targets for migraine treatment and contribute to further understanding the impact of T2DM or related metabolic disorders on an individual's health.

Fate of organic micropollutants during brackish water desalination for drinking water production in decentralized capacitive electrodialysis.

Capacitive electrodialysis (CED) is an emerging and promising desalination technology for decentralized drinking water production. Brackish water, often used as a drinking water source, may contain organic micropollutants (OMPs), thus raising environmental and health concerns. This study investigated the transport of OMPs in a fully-functional decentralized CED system for drinking water production under realistic operational conditions. Eighteen environmentally-relevant OMPs (20 µg L-1) with different physicochemical properties (charge, size, hydrophobicity) were selected and added to the feed water. The removal of OMPs was significantly lower than that of salts (∼94%), mainly due to their lower electrical mobility and higher steric hindrance. The removal of negatively-charged OMPs reached 50% and was generally higher than that of positively-charged OMPs (31%), whereas non-charged OMPs were barely transported. Marginal adsorption of OMPs was found under moderate water recovery (50%), in contrast to significant adsorption of charged OMPs under high water recovery (80%). The five-month operation demonstrated that the CED system could reliably produce water with low salt ions and TOC concentrations, meeting the respective WHO requirements. The specific energy consumption of the CED stack under 80% water recovery was 0.54 kWh m-3, which is competitive to state-of-the-art RO, ED, and emerging MCDI in brackish water desalination. Under this condition, the total OPEX was 2.43 € m-3, of which the cost of membrane replacement contributed significantly. Although the CED system proved to be a robust, highly adaptive, and fully automated technology for decentralized drinking water production, it was not highly efficient in removing OMPs, especially non-charged OMPs.

Transport of organic solutes in ion-exchange membranes: Mechanisms and influence of solvent ionic composition.

Ion-exchange membrane (IEM)-based processes are used in the industry or in the drinking water production to achieve selective separation. The transport mechanisms of organic solutes/micropollutants (i.e., paracetamol, clofibric acid, and atenolol) at a single-membrane level in diffusion cells were similar to that of salts (i.e., diffusion, convection, and electromigration). The presence of an equal concentration of salts at both sides of the membrane slightly decreased the transport of organics due to lower diffusion coefficients of organics in salts and the increase of hindrance and/or decrease of partitioning in the membrane phase. In the presence of a salt gradient, diffusion was the main transport mechanism for non-charged organics, while the counter-transport of salts promoted the transport of charged organics through electromigration (electroneutrality). Conversely, the co-transport of salts hindered the transport of charged organics, where diffusion was the main transport mechanism of the latter. Although convection played a role in the transport of non-charged organics, its influence on the charged solutes was minimal due to the dominant electromigration. Positron annihilation lifetime spectroscopy showed a bimodal size distribution of free-volume elements of IEMs, with both classes of free-volume elements contributing to salt transport, while larger organics can only transport through the larger class.

Complete oxidation of organic waste under mild supercritical water oxidation by combining effluent recirculation and membrane filtration.

Supercritical water oxidation (SCWO) is a technology that can oxidize various organic (wet) wastes into CO2. Complete oxidation of specific organics with SCWO goes in tandem with tailored conditions, typically involving elevated operating temperatures, long residence times, high oxidizer-to-waste ratios, or a combination of those, which promote difficulties, e.g., corrosion. These challenges hamper the practical implementation of SCWO, albeit SCWO offers excellent oxidation efficiencies. This work proposes a novel process combining mild supercritical water oxidation (SCWO) with membrane filtration to enhance the oxidation of organics. The modified SCWO works at mild reaction conditions (i.e., 380 °C, 25 MPa and oxidizer equivalence ratios as low as 1.5) to potentially decrease the risks. The membrane filtration discards clean effluent and recycles the retentate (containing incomplete oxidized organics) back to the mild SCWO process for further oxidation, thereafter resulting in near-complete removal of organics. Fresh feed is continuously added, as in the conventional process, along with recycled retentate to guarantee the throughput of the modified SCWO process. A mixture of SCWO-resistant volatile fatty acids (TOC = 4000 mg·L-1) was studied to validate the proposed process. The proposed process in this study enhances the organic decomposition from 43.2% to 100% at mild conditions with only 10% capacity loss. CO2 was the dominant gas product with traces of CO and H2. Carbon output in the gas products increased with recirculation and got close to the carbon input of the freshly added feed ultimately. The results indicated that the proposed process maximized the benefits of both technologies, which allows the development of a technological process for supercritical water oxidation, as well as a new stratagem for waste treatment.