Oferta de prep em organizações comunitárias: estudo comparativo com serviços convencionais / Prep provision in community organizations: a comparative study with conventional services

RESUMO OBJETIVO: Avaliar se adolescentes de minorias sexuais que iniciaram a profilaxia pré-exposição sexual (PrEP) em organizações comunitárias (OC) apresentam maior vulnerabilidade social e ao HIV em comparação com adolescentes em PrEP de um serviço de saúde convencional. Além disso, avaliar se esses adolescentes tiveram um acesso mais oportuno à profilaxia. MÉTODOS: Estudo demonstrativo da efetividade de PrEP, realizado na cidade de São Paulo, em duas OC, localizadas no centro (OC-centro) e na periferia (OC-periferia), e em um serviço convencional de testagem para o HIV (CTA-centro). Foram elegíveis para PrEP, entre 2020 e 2022, adolescentes homens cisgêneros que fazem sexo com homens (aHSH), travestis, mulheres transexuais e pessoas transfemininas (aTTrans), de 15 a 19 anos, HIV-negativos e com práticas de maior risco para o HIV. Indicadores de acesso oportuno e de vulnerabilidades dos adolescentes iniciando PrEP nas OC foram analisados, tendo por referência o CTA-centro e empregando regressão logística multinomial. RESULTADOS: 608 adolescentes iniciaram PrEP nas OC e CTA-Centro. Adolescentes das OC estiveram associados a um menor tempo de início de PrEP (1-7 dias; OC-periferia: ORa = 2,91; IC95% 1,22-6,92; OC-centro: ORa = 1,91; IC95% 1,10-3,31); e a um menor IDH de moradia (OC-centro: ORa = 0,97; IC95% 0,94-1,00; OC-periferia: ORa = 0,82; IC95% 0,78-0,86). Na OC-periferia houve aumento na chance de os adolescentes serem mais jovens (ORa = 3,06; IC95% 1,63-5,75) e morarem mais próximos ao serviço (ORa = 0,82; IC95% 0,78-0,86, média 7,8 km). Enquanto adolescentes da OC-centro estiveram associados ao maior conhecimento prévio de PrEP (ORa = 2,01; IC95% 1,10-3,91) e a alta percepção de risco (ORa = 2,02; IC95% 1,18-3,44). Não estiveram associadas aos adolescentes das OC as práticas sexuais de maior risco e as situações de vulnerabilidade ao HIV. CONCLUSÕES: A oferta de PrEP nas OC facilitou o acesso de adolescentes vulnerabilizados e pode contribuir para reduzir inequidades.

ABSTRACT OBJECTIVE: To evaluate whether adolescents from sexual minorities who initiated pre-exposure prophylaxis (PrEP) in community-based organizations (COs) are more socially and HIV-vulnerable compared with their counterparts from a conventional health service. In addition, to evaluate whether these adolescents had more timely access to prophylaxis METHODS: A PrEP demonstration study was conducted in the city of São Paulo in two COs, located in the center (CO-center) and the outskirts (CO-outskirts), and a conventional HIV testing service (CTA-center). Between 2020 and 2022, cisgender male adolescents who have sex with men (aMSM), transgender and gender diverse adolescents (aTTrans) aged 15 to 19 years, HIV-negative, with higher-risk practices for HIV were eligible for PrEP. Indicators of timely access and vulnerabilities of adolescents initiating PrEP in COs were analyzed using CTA-center as a reference and multinomial logistic regression. RESULTS: 608 adolescents initiated PrEP in COs and CTA-center. Adolescents from COs were associated with a shorter time to PrEP initiation (1-7 days; CO-outskirts: ORa = 2.91; 95%CI 1.22-6.92; CO-center: ORa = 1.91; 95%CI 1.10-3.31); and a lower housing Human Development Index (HDI) (CO-center: ORa = 0.97; 95%CI 0.94-1.00; CO-outskirts: ORa = 0.82; 95%CI 0.78-0.86). In CO-outskirts, there was an increased chance of adolescents being younger (ORa = 3.06; 95%CI 1.63-5.75) and living closer to the service (ORa = 0.82; 95%CI 0.78-0.86, mean 7.8 km). While adolescents from the CO-center were associated with greater prior knowledge of PrEP (ORa = 2.01; 95%CI 1.10-3.91) and high-risk perception (ORa = 2.02; 95%CI 1.18-3.44), adolescents from the COs were not associated with higher-risk sexual practices and situations of vulnerability to HIV. CONCLUSION: The provision of PrEP in the COs facilitated access for vulnerable adolescents and may contribute to reducing inequities.

HIV prevalence among transgender women in Northeast Brazil - Findings from two Respondent Driven Sampling studies.

BACKGROUND: The HIV epidemic still high among key-populations in Brazil, especially among transgender women (TGW). The aim of this study was to investigate the prevalence of HIV infection among TGW and to analyze factors associated with HIV seropositivity across two cross-sectional surveys conducted in Salvador, Bahia, one of the largest urban centers of Brazil. METHODS: The studies were conducted between 2014 and 2016 and 2016-2017 and employed Respondent-Driven Sampling (RDS) sampling, comprising 127 and 161 TGW residents of Salvador, Bahia. The outcome was the positive rapid antigen testing for HIV infection. Odds ratios (OR) and 95% confidence intervals (95%CI) were obtained using binomial logistic regression. RESULTS: The HIV prevalence was 9.0% (95%CI: 4.2-18.2) and 24.3% (95%CI: 16.2-34.9). In the first study, factors associated with HIV prevalence were experiencing discrimination by the family (OR 8.22; 95%CI: 1.49-45.48) and by neighbors (OR 6.55; 95%CI: 1.12-38.14) as well as having syphilis (OR 6.56; 95%CI:1.11-38.65); in the subsequent study gender-based discrimination (OR 8.65; 95%CI:1.45-51.59) and having syphilis (OR 3.13; 95%CI: 1.45-51.59) were associated with testing positive for HIV. CONCLUSION: We found disproportionately high HIV prevalence among TGW, which underscores the context of vulnerability for this population. The data point to the urgency for intensification and expansion of access to HIV prevention and strategies to stop discrimination in health care and services for this population.

Factors Associated with PrEP Refusal Among Transgender Women in Northeastern Brazil.

Brazil has recently integrated HIV Pre-exposure Prophylaxis (PrEP) into its public health system and offered to key populations such as transgender women (TGW). This study investigates factors associated with PrEP refusal among TGW living in one of the largest and poorest cities of Brazil. We recruited 127 TGW using Respondent Driven Sampling (RDS) in Salvador, Brazil. Latent class analysis (LCA) was used to define acceptability of PrEP. Two latent classes were identified: "high acceptability of PrEP" (91.3%) and "PrEP refusal" (8.7%). PrEP was less acceptable among white TGW and among those age 25 or older, with income above minimum wage (≥ US$252.87), and reporting unprotected receptive anal intercourse with (URAI) causal partners. The findings highlight how nuanced strategies that takes into consideration unique characteristics are needed to effectively address the acceptability of PrEP.

Gender-based discrimination and unprotected receptive anal intercourse among transgender women in Brazil: A mixed methods study.

INTRODUCTION: Discrimination related to gender identity may directly influence vulnerability to HIV through increased exposure to unprotected receptive anal intercourse (URAI). Little is known about the relationship between gender-based discrimination (GBD) and URAI with stable partners among transgender women. METHODS: This mixed-methods research began with a cross-sectional survey conducted between 2014 and 2016 with transgender women in Salvador, the capital city in one of the poorest regions in Brazil. Respondent-driven sampling was used to recruit the study population. GBD was defined through Latent Class Analysis. Additionally, 19 semi-structured interviews with participants were transcribed and analyzed through thematic content analysis. RESULTS: URAI with stable partners was commonly reported (37.3%). GDB was positively associated with URAI among stable partners (OR = 6.47; IC 95%: 1.67-25.02). The analysis of the interviews illustrated how GBD impacted transgender women in diverse ways. Experiences with GBD perpetrated by the family often initiated a trajectory of economic vulnerability that led many to engage in survival sex work. The constant experience with GBD contributed to participants feeling an immense sense of trust with their stable partners, ultimately diminished their desire to use condoms. Further, the high frequency of GBD contributed to poor mental health overall, though some participants said engagement in transgender advocacy efforts provided a vital source of resilience and support. CONCLUSION: Our mixed-method study capitalizes upon the strengths of diverse data sets to produce a holistic understanding of GBD and URAI with stable partners. Furthermore, by confirming the association between greater GBD and URAI, we have demonstrated how GBD can impact condom negotiation in diverse relationships.

From Pill to Condom, or Nothing at all: HIV Diagnosis and Discontinuation of Highly Effective Contraceptives Among Women in Northeast Brazil.

This is a cross-sectional study examining highly effective contraceptive (HEC) use among HIV-positive women in Salvador, Brazil. We used multivariate logistic regression to look for predictors of alternative contraceptive choices among women who discontinued HEC after HIV diagnosis. Of 914 participants surveyed, 38.5% of participants used HEC before but not after diagnosis. Of these, 65.9% used condoms alone; 19.3% used no protection; and 14.8% reported abstinence. Use of condoms alone was associated with a history of other sexually transmitted infections (AOR 2.18, 95% CI 1.09-4.66, p = 0.029). Abstinence was associated with recent diagnosis (AOR 8.48, 95% CI 2.20-32.64, p = 0.002). Using no method was associated with age below 25 (AOR 5.13, 95% CI 1.46-18.00, p = 0.011); income below minimum wage (AOR 2.54, 95% CI 1.31-4.92, p = 0.006); HIV-positive partner status (AOR 2.69, 95% CI 1.03-7.02, p = 0.043); and unknown partner status (AOR 2.90, 95% CI 1.04-8.05, p = 0.042). Improved contraceptive counseling is needed after HIV diagnosis. Continuation of HEC should be encouraged for women wishing to prevent pregnancy, and may increase contraceptive coverage among HIV-positive women.

La importancia de los derechos humanos en la respuesta ante el avance de la epidemia de la infección por el virus del Zika

[RESUMEN]. A fines del 2015, un aumento del número de lactantes nacidos con microcefalia en comunidades pobres del nordeste de Brasil dio lugar a una investigación en la cual se determinó que la causa era la infección prenatal por el virus del Zika. Actualmente, este virus circula en 69 países y ha afectado embarazos en 29 países. Los funcionarios de salud pública, los responsables de las políticas y los organismos internacionales están considerando intervenciones para abordar las consecuencias para la salud de la epidemia de la infección por el virus del Zika. Hasta la fecha, las respuestas de salud pública se han centrado en la erradicación de mosquitos vectores, los servicios de salud sexual y reproductiva, el conocimiento y la tecnología (como las pruebas de diagnóstico y el desarrollo de vacunas), y la preparación del sistema de salud. En este artículo resumimos las respuestas que tuvieron lugar hasta la fecha y aplicamos principios de derechos humanos y otros conexos, como la no discriminación, la participación, el contexto jurídico y de políticas, y la rendición de cuentas para detectar las deficiencias y ofrecer sugerencias de respuestas más equitativas, eficaces y sostenibles.

[ABSTRACT]. In late 2015, an increase in the number of infants born with microcephaly in poor communities in northeast Brazil prompted investigation of antenatal Zika infection as the cause. Zika now circulates in 69 countries, and has affected pregnancies of women in 29 countries. Public health officials, policymakers, and international organizations are considering interventions to address health consequences of the Zika epidemic. To date, public health responses have focused on mosquito vector eradication, sexual and reproductive health services, knowledge and technology including diagnostic test and vaccine development, and health system preparedness. We summarize responses to date and apply human rights and related principles including nondiscrimination, participation, the legal and policy context, and accountability to identify shortcomings and to offer suggestions for more equitable, effective, and sustainable Zika responses.

Engaging Human Rights in the Response to the Evolving Zika Virus Epidemic.

In late 2015, an increase in the number of infants born with microcephaly in poor communities in northeast Brazil prompted investigation of antenatal Zika infection as the cause. Zika now circulates in 69 countries, and has affected pregnancies of women in 29 countries. Public health officials, policymakers, and international organizations are considering interventions to address health consequences of the Zika epidemic. To date, public health responses have focused on mosquito vector eradication, sexual and reproductive health services, knowledge and technology including diagnostic test and vaccine development, and health system preparedness. We summarize responses to date and apply human rights and related principles including nondiscrimination, participation, the legal and policy context, and accountability to identify shortcomings and to offer suggestions for more equitable, effective, and sustainable Zika responses.

Barriers to HIV testing, linkage to care, and treatment adherence: a cross-sectional study from a large urban center of Brazil / Obstáculos a las pruebas de detección del VIH, la vinculación con la atención y la observancia terapéutica: Estudio transversal de un importante centro urbano de Brasil

ABSTRACT Objective Early, continued engagement with the HIV treatment continuum can help achieve viral suppression, though few studies have explored how risk factors for delays differ across the continuum. The objective of this study was to identify predictors of delayed diagnosis, delayed linkage to care, and nonadherence to treatment in the city of Salvador, Bahia, Brazil. Methods Data were collected during 2010 in a cross-sectional study with a sample (n = 1 970) of HIV-infected individuals enrolled in care. Multiple logistic regression analyses identified sociodemographic variables, behaviors, and measures of health service quality that were associated with delayed diagnosis, delayed linkage to care, and treatment nonadherence. Results For delayed diagnosis, male gender (adjusted odds ratio (AOR), 3.02; 95% confidence interval (CI), 2.0–4.6); age 45 years and older (AOR, 1.67; 95% CI, 1.1–2.5); and provider-initiated testing (AOR, 3.00; 95% CI, 2.1–4.4) increased odds, while drug use (AOR, 0.29; 95% CI, 0.2–0.5) and receiving results in a private space (AOR, 0.37; 95% CI, 0.2–0.8) decreased odds. For delayed linkage to care, unemployment (AOR, 1.42; 95% CI, 1.07–1.9) and difficulty understanding or speaking with a health care worker (AOR, 1.61; 95% CI, 1.2–2.1) increased odds, while posttest counseling (AOR, 0.49; 95% CI, 0.3–0.7) decreased odds. For nonadherence, experiencing verbal or physical discrimination related to HIV (AOR, 1.94; 95% CI, 1.3–3.0) and feeling mistreated or not properly attended to at HIV care (AOR, 1.60; 95% CI, 1.0–2.5) increased odds, while posttest counseling (AOR, 0.34; 95% CI, 0.2–0.6) decreased odds. Conclusions More attention is needed on how policies, programs, and research can provide tailored support across the treatment continuum.

RESUMEN Objetivo La participación temprana y continua en el continuo de tratamiento de la infección por el VIH puede ayudar a lograr la supresión viral, aunque pocos estudios han explorado la manera en que los factores de riesgo debidos a los retrasos difieren a lo largo del proceso continuo. El objetivo de este estudio fue determinar los factores predictivos de un diagnóstico tardío, la demora en la vinculación con la atención y el incumplimiento del régimen terapéutico en la ciudad de Salvador de Bahía, en Brasil. Métodos Se recopilaron datos en un estudio transversal realizado durante el 2010, con una muestra (n = 1 970) de personas con la infección por el VIH que recibían atención. Por medio de múltiples análisis de regresión logística se determinaron variables sociodemográficas, comportamientos y mediciones de la calidad del servicio de salud que estaban asociadas a un diagnóstico tardío, así como a la demora en la vinculación con la atención y el incumplimiento del régimen terapéutico. Resultados Con relación a los diagnósticos tardíos, ser de sexo masculino (razón de posibilidades ajustada (AOR) 3,02; intervalo de confianza (IC) de 95%, 2,0-4,6), tener más de 45 años (AOR, 1,67; IC de 95%, 1,1-2,5) y que las pruebas hayan sido iniciadas por el proveedor (AOR, 3,00; IC de 95%, 2,1-4,4) aumentaron las probabilidades, mientras que el consumo de drogas (AOR, 0,29; IC de 95%, 0.2-0.5) y la recepción de los resultados en un espacio privado (AOR, 0,37; IC de 95%, 0,2-0,8) disminuyeron las probabilidades. Con respecto a la vinculación tardía a la atención, el desempleo (AOR, 1,42; IC de 95%, 1,07-1,9) y las dificultades para comprender al trabajador de salud o hablar con él (AOR, 1,61; IC de 95%, 1,2-2,1) aumentaron las probabilidades, mientras que la orientación posterior a las pruebas (AOR, 0,49; IC de 95%, 0,3-0,7) disminuyó las probabilidades. Con respecto al incumplimiento del régimen terapéutico, la discriminación verbal o física relacionada con la infección por el VIH (AOR, 1,94; IC de 95%, 1,3-3,0) y el sentirse maltratado o no atendido adecuadamente en los establecimientos de atención (AOR, 1,60; IC de 95%, 1,0-2,5) aumentaron las probabilidades, mientras que la orientación posterior a las pruebas (AOR, 0,34; IC de 95%, 0,2-0,6) disminuyó las probabilidades. Conclusiones Debe prestarse mayor atención a la forma en que las políticas, los programas y la investigación pueden prestar apoyo personalizado a lo largo del proceso continuo de tratamiento.

Barriers to HIV testing, linkage to care, and treatment adherence: a cross-sectional study from a large urban center of Brazil / Obstáculos a las pruebas de detección del VIH, la vin¬culación con la atención y la observancia terapéutica: Estudio transversal de un importante centro urbano de Brasil

Objective: Early, continued engagement with the HIV treatment continuum can help achieve viral suppression, though few studies have explored how risk factors for delays differ across the continuum. The objective of this study was to identify predictors of delayed diagnosis, delayed linkage to care, and nonadherence to treatment in the city of Salvador, Bahia, Brazil. Methods: Data were collected during 2010 in a cross-sectional study with a sample (n = 1 970) of HIV-infected individuals enrolled in care. Multiple logistic regression analyses identified sociodemographic variables, behaviors, and measures of health service quality that were associated with delayed diagnosis, delayed linkage to care, and treatment nonadherence. Results: For delayed diagnosis, male gender (adjusted odds ratio (AOR), 3.02; 95% confidence interval (CI), 2.0–4.6); age 45 years and older (AOR, 1.67; 95% CI, 1.1–2.5); and provider-initiated testing (AOR, 3.00; 95% CI, 2.1–4.4) increased odds, while drug use (AOR, 0.29; 95% CI, 0.2–0.5) and receiving results in a private space (AOR, 0.37; 95% CI, 0.2–0.8) decreased odds. For delayed linkage to care, unemployment (AOR, 1.42; 95% CI, 1.07–1.9) and difficulty understanding or speaking with a health care worker (AOR, 1.61; 95% CI, 1.2–2.1) increased odds, while posttest counseling (AOR, 0.49; 95% CI, 0.3–0.7) decreased odds. For nonadherence, experiencing verbal or physical discrimination related to HIV (AOR, 1.94; 95% CI, 1.3–3.0) and feeling mistreated or not properly attended to at HIV care (AOR, 1.60; 95% CI, 1.0–2.5) increased odds, while posttest counseling (AOR, 0.34; 95% CI, 0.2–0.6) decreased odds. Conclusions: More attention is needed on how policies, programs, and research can provide tailored support across the treatment continuum.

Objetivo: La participación temprana y continua en el continuo de tratamiento de la infección por el VIH puede ayudar a lograr la supresión viral, aunque pocos estudios han explorado la manera en que los factores de riesgo debidos a los retrasos difieren a lo largo del proceso continuo. El objetivo de este estudio fue determinar los factores predictivos de un diagnóstico tardío, la demora en la vinculación con la atención y el incumplimiento del régimen terapéutico en la ciudad de Salvador de Bahía, en Brasil. Métodos: Se recopilaron datos en un estudio transversal realizado durante el 2010, con una muestra (n = 1 970) de personas con la infección por el VIH que recibían atención. Por medio de múltiples análisis de regresión logística se determinaron variables sociodemográficas, comportamientos y mediciones de la calidad del servicio de salud que estaban asociadas a un diagnóstico tardío, así como a la demora en la vinculación con la atención y el incumplimiento del régimen terapéutico. Resultados: Con relación a los diagnósticos tardíos, ser de sexo masculino (razón de posibilidades ajustada (AOR) 3,02; intervalo de confianza (IC) de 95%, 2,0-4,6), tener más de 45 años (AOR, 1,67; IC de 95%, 1,1-2,5) y que las pruebas hayan sido iniciadas por el proveedor (AOR, 3,00; IC de 95%, 2,1-4,4) aumentaron las probabilidades, mientras que el consumo de drogas (AOR, 0,29; IC de 95%, 0.2-0.5) y la recepción de los resultados en un espacio privado (AOR, 0,37; IC de 95%, 0,2-0,8) disminuyeron las probabilidades. Con respecto a la vinculación tardía a la atención, el desempleo (AOR, 1,42; IC de 95%, 1,07-1,9) y las dificultades para comprender al trabajador de salud o hablar con él (AOR, 1,61; IC de 95%, 1,2-2,1) aumentaron las probabilidades, mientras que la orientación posterior a las pruebas (AOR, 0,49; IC de 95%, 0,3-0,7) disminuyó las probabilidades. Con respecto al incumplimiento del régimen terapéutico, la discriminación verbal o física relacionada con la infección por el VIH (AOR, 1,94; IC de 95%, 1,3-3,0) y el sentirse maltratado o no atendido adecuadamente en los establecimientos de atención (AOR, 1,60; IC de 95%, 1,0-2,5) aumentaron las probabilidades, mientras que la orientación posterior a las pruebas (AOR, 0,34; IC de 95%, 0,2-0,6) disminuyó las probabilidades. Conclusiones: Debe prestarse mayor atención a la forma en que las políticas, los programas y la investigación pueden prestar apoyo personalizado a lo largo del proceso continuo de tratamiento.

Mind the gap: implementation challenges break the link between HIV/AIDS research and practice.

Sampling strategies such as respondent-driven sampling (RDS) and time-location sampling (TLS) offer unique opportunities to access key populations such as men who have sex with men (MSM) and transgender women. Limited work has assessed implementation challenges of these methods. Overcoming implementation challenges can improve research quality and increase uptake of HIV services among key populations. Drawing from studies using RDS in Brazil and TLS in Peru, we summarize challenges encountered in the field and potential strategies to address them. In Brazil, study site selection, cash incentives, and seed selection challenged RDS implementation with MSM. In Peru, expansive geography, safety concerns, and time required for study participation complicated TLS implementation with MSM and transgender women. Formative research, meaningful participation of key populations across stages of research, and transparency in study design are needed to link HIV/AIDS research and practice. Addressing implementation challenges can close gaps in accessing services among those most burdened by the epidemic.

[Building bridges: interdisciplinarity in practice. PopTrans Study: a study with transvestites and transsexual women in Salvador, Bahia State, Brazil]. / Construindo pontes: a prática da interdisciplinaridade. Estudo PopTrans: um estudo com travestis e mulheres transexuais em Salvador, Bahia, Brasil.

Trans persons, including transvestites and transsexual women, show disproportionately high HIV/AIDS rates when compared to the rest of the population. However, few quantitative/qualitative studies have addressed trans persons in Brazil. Thus, a team of researchers from different fields is developing an interdisciplinary research project with the objective of shedding light on living conditions and ways of life among transvestites and transsexual women, while investigating determinant factors for HIV infection, syphilis, and hepatitis B and C. The article is intended to describe the experience with the implementation and development of an ethno-epidemiological study in Salvador, Bahia State, Brazil. Mapping the population began with a formative survey that was crucial for orienting the epidemiological survey. The production of ethno-epidemiological data posed a daily challenge for the researchers, triggering a series of reflections on the limits of our concepts and categories for translating the diversity of study participants' practices and experiences.

Mind the gap: implementation challenges break the link between HIV/AIDS research and practice / Cuidado com a distância: desafios na implementação rompem o elo entre pesquisa e prática em HIV/AIDS / Atentos a la brecha: desafíos de implementación rompen el vínculo entre el VIH/SIDA investigación y práctica

Abstract: Sampling strategies such as respondent-driven sampling (RDS) and time-location sampling (TLS) offer unique opportunities to access key populations such as men who have sex with men (MSM) and transgender women. Limited work has assessed implementation challenges of these methods. Overcoming implementation challenges can improve research quality and increase uptake of HIV services among key populations. Drawing from studies using RDS in Brazil and TLS in Peru, we summarize challenges encountered in the field and potential strategies to address them. In Brazil, study site selection, cash incentives, and seed selection challenged RDS implementation with MSM. In Peru, expansive geography, safety concerns, and time required for study participation complicated TLS implementation with MSM and transgender women. Formative research, meaningful participation of key populations across stages of research, and transparency in study design are needed to link HIV/AIDS research and practice. Addressing implementation challenges can close gaps in accessing services among those most burdened by the epidemic.

Resumo: Estratégias de amostragem como respondent-driven sampling (RDS) e time-location sampling (TLS) são importantes opções metodológicas para acessar populações chaves para a epidemia de HIV/AIDS como homens que fazem sexo com homens (HSH) e mulheres transexuais. Porém são poucos os estudos que avaliam desafios de implementação desses métodos. Objetivamos apresentar os principais desafios na implementação dos RDS no Brasil e TLS no Peru. No Brasil, o local da pesquisa, a seleção das sementes, e o tipo de ressarcimento foram desafios na implementação do RDS-HSH. E no Peru, as questões geográficas, preocupações com segurança, e o tempo necessário para participar no estudo complicaram o TLS com HSH e mulheres transexuais. Pesquisa formativa, participação das populações chaves em todas as fases da pesquisa, e transparência no desenvolvimento do estudo são necessários para utilização prática dos resultados. Melhorar a implementação dessas pesquisas pode contribuir para aumentar o acesso aos serviços de prevenção e controle do HIV/AIDS entre aqueles que mais precisam.

Resumen: Estrategias de muestra como respondent-driven sampling (RDS) y time-location sampling (TLS) son importantes opciones metodológicas para acceder a poblaciones claves para la epidemia de VIH/SIDA como los hombres que tienen sexo con hombres (HSH) y mujeres transexuales. No obstante, son pocos los estudios que evalúan los desafíos de implementación de esos métodos. Tenemos como objetivo presentar los principales desafíos en la implementación de los RDS en Brasil y TLS en Perú. En Brasil, el lugar de la investigación, la selección de las muestras, y el tipo de compensación fueron desafíos en la implementación del RDS-HSH. Y en Perú, las cuestiones geográficas, preocupaciones con la seguridad, y el tiempo necesario para participar en el estudio complicaron el TLS con HSH y mujeres transexuales. Se trata de una investigación formativa, con participación de las poblaciones claves en todas las fases de la investigación, y transparencia en el desarrollo del estudio, todo ello necesario para la utilización práctica de los resultados. Mejorar la implementación de esas investigaciones puede contribuir a aumentar el acceso a los servicios de prevención y control del VIH/SIDA entre aquellos que más lo necesitan.

Late presentation to HIV/AIDS care in Brazil among men who self-identify as heterosexual.

OBJECTIVE: To analyze the factors associated with late presentation to HIV/AIDS services among heterosexual men. METHODS: Men infected by HIV who self-identified as heterosexual (n = 543) were included in the study. Descriptive, biivariate and logistic regression analyses were performed to evaluate the factors associated with late presentation (defined as individuals whose first CD4 count was <350 cells/mm3) in the study population. RESULTS: The prevalence of late presentation was 69.8%. The multivariate logistic analysis showed testing initiated by the provider (ORadjusted 3.75; 95%CI 2.45-5.63) increased the odds of late presentation. History of drug use (ORadjusted 0.59; 95%CI 0.38-0.91), history of having sexually transmitted infections (ORadjusted 0.64; 95%CI 0.42-0.97), and having less education (ORadjusted 0.63; 95%CI 0.41-0.97) were associated with a decreased odds of LP. CONCLUSIONS: Provider initiated testing was the only variable to increase the odds of late presentation. Since the patients in this sample all self-identified as heterosexual, it appears that providers are not requesting they be tested for HIV until the patients are already presenting symptoms of AIDS. The high prevalence of late presentation provides additional evidence to shift towards routine testing and linkage to care, rather than risk-based strategies that may not effectively or efficiently engage individuals infected with HIV.

Barriers to HIV testing, linkage to care, and treatment adherence: a cross-sectional study from a large urban center of Brazil.

OBJECTIVE: Early, continued engagement with the HIV treatment continuum can help achieve viral suppression, though few studies have explored how risk factors for delays differ across the continuum. The objective of this study was to identify predictors of delayed diagnosis, delayed linkage to care, and nonadherence to treatment in the city of Salvador, Bahia, Brazil. METHODS: Data were collected during 2010 in a cross-sectional study with a sample (n = 1 970) of HIV-infected individuals enrolled in care. Multiple logistic regression analyses identified sociodemographic variables, behaviors, and measures of health service quality that were associated with delayed diagnosis, delayed linkage to care, and treatment nonadherence. RESULTS: For delayed diagnosis, male gender (adjusted odds ratio (AOR), 3.02; 95% confidence interval (CI), 2.0-4.6); age 45 years and older (AOR, 1.67; 95% CI, 1.1-2.5); and provider-initiated testing (AOR, 3.00; 95% CI, 2.1-4.4) increased odds, while drug use (AOR, 0.29; 95% CI, 0.2-0.5) and receiving results in a private space (AOR, 0.37; 95% CI, 0.2-0.8) decreased odds. For delayed linkage to care, unemployment (AOR, 1.42; 95% CI, 1.07-1.9) and difficulty understanding or speaking with a health care worker (AOR, 1.61; 95% CI, 1.2-2.1) increased odds, while posttest counseling (AOR, 0.49; 95% CI, 0.3-0.7) decreased odds. For nonadherence, experiencing verbal or physical discrimination related to HIV (AOR, 1.94; 95% CI, 1.3-3.0) and feeling mistreated or not properly attended to at HIV care (AOR, 1.60; 95% CI, 1.0-2.5) increased odds, while posttest counseling (AOR, 0.34; 95% CI, 0.2-0.6) decreased odds. CONCLUSIONS: More attention is needed on how policies, programs, and research can provide tailored support across the treatment continuum.

Barriers along the care cascade of HIV-infected men in a large urban center of Brazil.

Global and national HIV/AIDS policies utilize the care cascade to emphasize the importance of continued engagement in HIV services from diagnosis to viral suppression. Several studies have documented barriers that men experience in accessing services at specific stages of care, but few have analyzed how these barriers operate along the care cascade. Brazil offers a unique setting for analyzing barriers to HIV care because it is a middle-income country with a large HIV epidemic and free, universal access to HIV/AIDS services. Semi-structured interviews were conducted in 2011 with HIV-infected men (n = 25) receiving care at the only HIV/AIDS state reference center in Salvador, Brazil, the third largest city in the country. Interviews were transcribed and coded for analysis. Researchers identified barriers to services along the care cascade: health service-related obstacles (poor-quality care, lengthy wait times, and drug supply problems); psychosocial and emotional challenges (fear of disclosure and difficulty accepting HIV diagnosis); indirect costs (transportation and absenteeism at work or school); low perceived risk of HIV; and toxicity and complexity of antiretroviral drug (ARV) regimens. The stages of the care cascade interrupted by each barrier were also identified. Most barriers affected multiple, and often all, stages of care, while toxicity and complexity of ARV regimens was only present at a single care stage. Efforts to eliminate more prevalent barriers have the potential to improve care continuity at multiple stages. Going forward, assessing the relative impact of barriers along one's entire care trajectory can help tailor improvements in service provision, facilitate achievement of viral suppression, and improve access to life-saving testing, treatment, and care.

Late presentation to HIV/AIDS care in Brazil among men who self-identify as heterosexual

ABSTRACT OBJECTIVE To analyze the factors associated with late presentation to HIV/AIDS services among heterosexual men. METHODS Men infected by HIV who self-identified as heterosexual (n = 543) were included in the study. Descriptive, biivariate and logistic regression analyses were performed to evaluate the factors associated with late presentation (defined as individuals whose first CD4 count was <350 cells/mm3) in the study population. RESULTS The prevalence of late presentation was 69.8%. The multivariate logistic analysis showed testing initiated by the provider (ORadjusted 3.75; 95%CI 2.45-5.63) increased the odds of late presentation. History of drug use (ORadjusted 0.59; 95%CI 0.38-0.91), history of having sexually transmitted infections (ORadjusted 0.64; 95%CI 0.42-0.97), and having less education (ORadjusted 0.63; 95%CI 0.41-0.97) were associated with a decreased odds of LP. CONCLUSIONS Provider initiated testing was the only variable to increase the odds of late presentation. Since the patients in this sample all self-identified as heterosexual, it appears that providers are not requesting they be tested for HIV until the patients are already presenting symptoms of AIDS. The high prevalence of late presentation provides additional evidence to shift towards routine testing and linkage to care, rather than risk-based strategies that may not effectively or efficiently engage individuals infected with HIV.

Construindo pontes: a prática da interdisciplinaridade. Estudo PopTrans: um estudo com travestis e mulheres transexuais em Salvador, Bahia, Brasil / Building bridges: interdisciplinarity in practice. PopTrans Study: a study with transvestites and transsexual women in Salvador, Bahia State, Brazil / Construyendo puentes: la práctica de la interdisciplinaridad. Estudio PopTrans: un estudio con travestis y mujeres transexuales en Salvador, Bahía, Brasil

Resumo: Pessoas trans, incluindo travestis, mulheres transexuais, apresentam taxas desproporcionalmente elevadas de HIV/AIDS em comparação com o restante da população. Entretanto, são poucos os estudos quantitativos/qualitativos com pessoas trans no Brasil. Assim, uma equipe de pesquisadores de diferentes áreas desenvolve um projeto de pesquisa interdisciplinar com o objetivo de conhecer as condições e os modos de vida, e ao mesmo tempo investigar fatores determinantes da infecção pelo HIV, sífilis e hepatites B e C entre travestis e mulheres transexuais. Neste artigo, pretende-se descrever a experiência de implantação e desenvolvimento do estudo com uma abordagem etnoepidemiológica em Salvador, Bahia, Brasil. O mapeamento da população começou com uma pesquisa formativa que foi crucial para orientar o inquérito epidemiológico. A produção de dados etnoepidemiológicos é um desafio cotidiano para os pesquisadores, produzindo uma série de reflexões sobre os limites de nossos conceitos e categorias para traduzir a diversidade de práticas e experiências das participantes da pesquisa.

Abstract: Trans persons, including transvestites and transsexual women, show disproportionately high HIV/AIDS rates when compared to the rest of the population. However, few quantitative/qualitative studies have addressed trans persons in Brazil. Thus, a team of researchers from different fields is developing an interdisciplinary research project with the objective of shedding light on living conditions and ways of life among transvestites and transsexual women, while investigating determinant factors for HIV infection, syphilis, and hepatitis B and C. The article is intended to describe the experience with the implementation and development of an ethno-epidemiological study in Salvador, Bahia State, Brazil. Mapping the population began with a formative survey that was crucial for orienting the epidemiological survey. The production of ethno-epidemiological data posed a daily challenge for the researchers, triggering a series of reflections on the limits of our concepts and categories for translating the diversity of study participants' practices and experiences.

Resumen: Personas transexuales, incluyendo travestis, mujeres transexuales, presentan tasas desproporcionalmente elevadas de VIH/SIDA, en comparación con el resto de la población. No obstante, son pocos los estudios cuantitativos/cualitativos con personas transexuales en Brasil. Por ello, un equipo de investigadores de diferentes áreas desarrolla un proyecto de investigación interdisciplinaria, con el fin de conocer las condiciones y modos de vida, y al mismo tiempo investigar factores determinantes de la infección por el VIH, sífilis y hepatitis B y C entre travestis y mujeres transexuales. En este artículo se pretende describir la experiencia de la implantación y desarrollo del estudio con un enfoque etnoepidemiológico en Salvador, Bahía, Brasil. El mapeo de la población comenzó con una investigación formativa que fue crucial para orientar la encuesta epidemiológica. La producción de datos etnoepidemiológicos se muestra como un desafío cotidiano para los investigadores, produciendo una serie de reflexiones sobre los límites de nuestros conceptos y categorías para traducir la diversidad de prácticas y experiencias de las participantes de la investigación.

Revisiting the use of condoms in Brazil.

INTRODUCTION: It is known that a single prevention strategy is not enough to control multiple HIV epidemics around the world and in Brazil. However, it is not only necessary to recognize the importance of condoms as part of the policy of HIV/AIDS prevention but also discuss its limits. In this article, we aim to investigate the use of condoms in Brazil, draw critical reflections, and understand how they can once again be highlighted in Brazil's prevention strategy going forward. METHODS: A narrative review of literature was conducted using keywords in PubMed. Reports from national surveys that guide the epidemiological and behavioral surveillance of the Brazilian Ministry of Health were also included. RESULTS: A total of 40 articles and 3 reports were included in the review and 11 intervention studies to promote the condom use; the main findings were as follows: 1) Despite the increase in national studies on sexual behavior, little attention is given to the role of condom use; 2) There are few studies examining the factors associated with condom use among key populations such as men who have sex with men (MSM), female sex workers (FSW), drug users (DU), and transvestites and transexuals (TT), while substantial studies focus on adolescents and women; 3) Evidence suggests that a combination of interventions is more effective. DISCUSSION: new prevention technologies must not lose sight of the critical importance of condoms, and efforts to reintroduce them should focus on the role of pleasure in addition to their potential to minimize the risk of HIV.

Revisiting the use of condoms in Brazil / Revisitando o uso do preservativo no Brasil

ABSTRACT Introduction: It is known that a single prevention strategy is not enough to control multiple HIV epidemics around the world and in Brazil. However, it is not only necessary to recognize the importance of condoms as part of the policy of HIV/AIDS prevention but also discuss its limits. In this article, we aim to investigate the use of condoms in Brazil, draw critical reflections, and understand how they can once again be highlighted in Brazil's prevention strategy going forward. Methods: A narrative review of literature was conducted using keywords in PubMed. Reports from national surveys that guide the epidemiological and behavioral surveillance of the Brazilian Ministry of Health were also included. Results: A total of 40 articles and 3 reports were included in the review and 11 intervention studies to promote the condom use; the main findings were as follows: 1) Despite the increase in national studies on sexual behavior, little attention is given to the role of condom use; 2) There are few studies examining the factors associated with condom use among key populations such as men who have sex with men (MSM), female sex workers (FSW), drug users (DU), and transvestites and transexuals (TT), while substantial studies focus on adolescents and women; 3) Evidence suggests that a combination of interventions is more effective. Discussion: new prevention technologies must not lose sight of the critical importance of condoms, and efforts to reintroduce them should focus on the role of pleasure in addition to their potential to minimize the risk of HIV.

RESUMO Introdução: No âmbito da atual política de prevenção do HIV/AIDS é necessário reconhecer a importância do preservativo masculino e discutir seus limites. Esse artigo objetivou investigar o uso do preservativo masculino no Brasil e elaborar reflexões críticas sobre o papel do mesmo no novo contexto da prevenção do HIV/AIDS. Métodos: Revisão narrativa sobre o uso do preservativo masculino no Brasil em diferentes grupos populacionais e fatores associados ao uso, por meio de buscas realizadas entre março e abril de 2013, utilizando-se descritores em inglês categorizados na base PubMed. Incluíram-se também documentos provenientes de inquéritos nacionais que orientam a vigilância epidemiológica e comportamental do Ministério da Saúde. Resultados: Incluí-se 40 artigos e 3 relatórios para caracterizar a produção de conhecimentos e outros 11 estudos de intervenção para promoção do uso de preservativos. Observou-se que: 1) apesar do aumento de estudos nacionais, estes apresentam baixa regularidade; 2) há poucos estudos sobre fatores associados ao uso de preservativo entre os grupos nos quais a epidemia se concentra, como homens que fazem sexo com homens (HSH), trabalhadoras sexuais (TS), usuários de drogas (UD) e travestis e transexuais (TT), e concentração entre adolescentes e mulheres; 3) combinação de intervenções mostrou-se mais efetiva do que uma só. Discussão: A reflexão e discussão do uso do preservativo no âmbito das novas tecnologias de prevenção devem não só enfatizar a importância do mesmo, mas também considerar o papel do prazer e do sexo nas intervenções combinadas, além do potencial de redução do risco de infecção por HIV.

Making the invisible, visible: a cross-sectional study of late presentation to HIV/AIDS services among men who have sex with men from a large urban center of Brazil.

BACKGROUND: Late presentation to testing, treatment and continued care has detrimental impacts on the health of HIV-positive individuals as well as their sexual partners' health. Men who have sex with men (MSM) experience disproportionately high rates of HIV both globally and in Brazil. However, the factors that inhibit linkage to care among MSM remain unclear. METHODS: We conducted a cross-sectional study of HIV-positive MSM (n = 740) enrolled in HIV/AIDS services in a large urban center of Brazil from August 2010 to June 2011. Descriptive, bivariate and multivariate statistics were conducted using STATA 12 to examine the relationship between a range of variables and late presentation, defined as having a first CD4 count <350 cells/mm3. RESULTS: Within the sample, the prevalence of LP was 63.1%. Men who self-identified as heterosexual (AOR 1.54 and 95% CI 1.08 - 2.20) compared to men who self-identified as homosexual and bisexual were at increased odds of late presentation. Additionally, men age 30 and older (AOR 1.56, 95% CI 1.01 - 2.43) compared to individuals age 18-29 experienced increased odds of late presentation among MSM. CONCLUSIONS: The prevalence of LP in this population was higher than noted in the global literature on LP among MSM. Heterosexual men and older age individuals experienced substantial barriers to HIV care. The stigma around same-sex behaviors and the current focus of HIV prevention and treatment campaigns on younger age individuals may limit patients' and providers' awareness of the risk for HIV and access to available services. In addition to addressing HIV-specific barriers to care, developing effective strategies to reduce late presentation in Brazil will require addressing social factors - such as stigma against diverse sexualities - to concretely identify and eliminate barriers to available services. Only in so doing can we make currently invisible people, visible.