ABSTRACT
We describe a case of a 37-year-old female, indicated for in vitro fertilisation. She developed skin rash on her trunk and limbs, during the treatment. RT-PCR results were positive in her blood and negative in her husband's blood and semen. Oocyte aspiration was performed, retrieving 7 oocytes, follicular fluid, and cumulus cells. RT-PCR results for the follicular fluid and cumulus cells were negative for ZIKV, and positive for only 2 oocytes. This is the first report in the literature analysing ZIKV in the follicular fluid, cumulus cells, and oocytes, and will contribute to the understanding of ZIKV infection and transmission.
Subject(s)
Oocytes/virology , Ovarian Follicle/virology , Ovulation Induction , Zika Virus Infection , Zika Virus/genetics , Adult , Female , Humans , Male , RNA, Viral/genetics , Real-Time Polymerase Chain Reaction , Semen/virology , Zika Virus Infection/diagnosis , Zika Virus Infection/transmission , Zika Virus Infection/virologyABSTRACT
We report on five unrelated Brazilian patients with heminasal aplasia associated with diverses anomalies, including lateral proboscis, and anomalies of the eye and first branchial arch. We suggest that these patients represent different conditions within the spectrum of the heminasal aplasia malformation. Clinical, genetic, and differential diagnosis are discussed.
Subject(s)
Abnormalities, Multiple/pathology , Anophthalmos/pathology , Facial Bones/abnormalities , Nose/abnormalities , Phenotype , Central Nervous System/abnormalities , Central Nervous System/diagnostic imaging , Facial Bones/diagnostic imaging , Female , Humans , Infant, Newborn , Magnetic Resonance Imaging , Male , Syndrome , Tomography, X-Ray ComputedABSTRACT
We report on two unrelated Brazilian boys who have craniofacial and digital anomalies resembling those reported with Teebi hypertelorism syndrome. Additional features such as cleft lip and palate, large uvula, atypical chin and abnormal scapulae were observed.
