Biodegradable Gg-cl-poly(NIPAm-co-AA)/-o-MWCNT based hydrogel for combined drug delivery system of metformin and sodium diclofenac: in vitro studies.

In the present study Gg-cl-poly(NIPA-co-AA) and Gg-cl-poly(NIPA-co-AA)/-o-MWCNT hydrogels were synthesized using free radical polymerization. We looked into whether combining metformin with diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), would be effective in examining complex formation and analysing the types and intensities of complexes that could result from metformin-diclofenac interactions. The interaction of metformin and diclofenac was studied in vitro at various pH levels and body temperatures. The structure and morphology of the produced hydrogel were characterised using FTIR spectra, SEM analysis, and drug loading tests. As a model drug, the hydrogel was loaded with metformin hydrochloride and sodium diclofenac (DS), and the medicines were released pH-dependently. To explore the drug release kinetics and mechanism, the zero order and first order kinetic models, the Korsemeyar-Peppas model, the Higuchi model, and the Hixson-Crowell model have all been employed. Drug release studies revealed notable characteristics in connection to physiologically predicted pH values, with a high release rate at pH = 9.2. At pH = 9.2, however, both metformin and sodium diclofenac exhibited a Fickian mechanism. Combination treatment may reduce the effective dose of a single drug and hinder metabolic rescue mechanisms. More study is needed to detect any negative effects on individuals.

Drug release and thermal properties of magnetic cobalt ferrite (CoFe2O4) nanocomposite hydrogels based on poly(acrylic acid-g-N-isopropyl acrylamide) grafted onto gum ghatti.

The aim of this study was to better understand the underlying drug release characteristics from Gg-cl-poly(NIPA-co-AA)/CoFe2O4 hydrogel containing metformin hydrochloride as model drug. Nanocomposite's hydrogel of gum ghatti free radical polymerization is used for the controlled release of metformin hydrogen chloride. Gum ghatti and CoFe2O4 nanoparticle dispersion were grafted by acrylic acid and N-isopropylacrylamide, employing graft copolymerization in the presence of N, N'-methylene-bis-acrylamide (MBA) as cross linker, and ammonium persulfate (APS) as initiator. The synthesized nanocomposites hydrogel was characterized using FTIR, SEM, TGA and DSC. Drugs were all released through diffusion in the hydrated matrix and polymer relaxation, irrespective of the drug solubility. In vitro drug release studies, at different pH values of pH = 4.0, 7.4 and 9.2 was employed. Drug release was influenced by the change of pH. The pH of 7.4 was considered as the optimized pH for maximum drug release. The nanocomposites hydrogel was loaded with metformin hydrochloride drug (100 mg) which is an antidiabetic drug to investigate the release profiles in PBS (pH 7.4). The effects of polymer level and initial drug loading on release depended on drug properties. Different models were studied for release kinetic studies which showed that the zero-order model suggested the best kinetics release studies in PBS (pH- 7.4) and showed sustained release. The kinetics of drug release were discovered to fit the Korsmeyer-Peppas model with n > 1, indicating a specific case II transport mechanism.

Aggregation behavior of pyridinium based ionic liquids in water--surface tension, 1H NMR chemical shifts, SANS and SAXS measurements.

The aggregation behavior of short alkyl chain ionic liquids (ILs), namely 1-butyl, or 1-hexyl or 1-octylpyridinium and 1-octyl-2-, or -3-, or -4-methylpyridinium chlorides, in water has been assessed using surface tension, electrical conductance, (1)H NMR, small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS) measurements. Critical aggregation concentrations (CACs), adsorption (at air/water interface) and thermodynamic parameters of aggregation have been reported. The values of CAC and area per adsorbed molecule decrease with the number of carbon atoms in the alkyl chain. The aggregation process is driven by both favorable enthalpy and entropy contributions. An attempt was made to examine the morphological features of the aggregates in water using SANS and SAXS methods. SANS and SAXS curves displayed diffuse structural peaks that could not be model fitted, and therefore, we calculated the mean aggregation numbers from the Q(max) assuming that IL molecules typically order into cubic type clusters.