ABSTRACT
Depression in patients with cancer negatively influences their physical symptoms, treatment success, coping, and quality of life and is associated with increased mortality. The reported prevalence of emotional distress in patients followed in hematology varies widely across studies. This study investigated the prevalence of depression and explored the possible associated factors in patients followed in a hematological department. Methods: in this descriptive cross-sectional study of patients followed in the hematology department of the University Hospital Mohammed VI of Marrakesh between August 2020 and December 2020, depression symptoms were assessed using Mini International Neuropsychiatric Interview test and Beck Depression Inventory. Results: 150 patients participated. Regarding their underlying pathology, 60% (90 patients) of patients were newly diagnosed with leukemia, and 8% patients were admitted for chronic anemia and 12% for lymphoma. Forty-eight percent of them had a characterized depressive episode. Four percent of these episodes were severe, 55% were moderate, and 41% were mild. Among all the factors, multivariate analysis showed that high prevalence of depression was associated with female gender and poor prognosis estimation by the patient.
ABSTRACT
Autologous hematopoietic stem cell transplantation (HSCT) for relapsed Hodgkin's lymphoma increases the risk of infection by using intensive chemotherapy. This risk is obviously ongoing given the increased virulence of severe COVID-19. We report a case of a young man with Hodgkin's lymphoma who received conditioning chemotherapy followed by autologous HSCT and tested positive for SARS-CoV-2 by polymerase chain reaction (PCR) during the early phase of aplasia with persistence of COVID-19 beyond 30 days with favorable follow-up and clinical improvement on treatment. For this type of patient with hematologic malignancy, viral infection can be fatal and strict medical precautions with isolation rules must be maintained, especially for SARS-CoV-2.
Subject(s)
COVID-19 , Hematopoietic Stem Cell Transplantation , Hodgkin Disease , Male , Humans , Hodgkin Disease/therapy , Hodgkin Disease/pathology , COVID-19/therapy , SARS-CoV-2 , Transplantation, AutologousABSTRACT
We present a case of a relapse of HL revealed by a skin involvement. A biopsy of the skin lesion showed infiltration by a mixed cellularity and Reed-Sternberg cells. The immunoreactivity was positive for CD30 and CD15. The patient was undergoing ICE protocol with good improvement after three cycles.