Role of histone deacetylases and sirtuins in the ischaemic stroke: a protocol for a systematic review and meta-analysis of animal studies.

BACKGROUND: Stroke is a major cause of global mortality and disability. Currently, the treatment of acute ischaemic stroke through reperfusion has posed several challenges, raising the need for complementary options to protect the ischaemic penumbra. Recent investigations have indicated that certain epigenetic factors, specifically, histone deacetylases (HDACs) and sirtuins, can be promising for ischaemic stroke therapy, with recent studies suggesting that inhibitors of HDACs or sirtuins may provide neuronal protection after ischaemic stroke. However, the impact of specific HDAC/sirtuin isoforms on the survival of neuronal cells following stroke is still uncertain. This study aims to provide a comprehensive overview of the function of HDACs and their modulators in the treatment of acute ischaemic stroke. METHODS: This systematic review and meta-analysis will encompass animal intervention studies that explore the efficacy of modulation of HDACs and sirtuins in the acute phase of ischaemic stroke. The review will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Electronic searches will be conducted in PubMed, Web of Science and Scopus, with subsequent screening by independent reviewers based on the established eligibility criteria. Methodological quality will be evaluated using the SYRCLE risk of bias tool. The primary outcomes will be infarct volume and functional response, with the secondary outcomes established a priori. Data pertaining to infarct volume will be used for random-effects meta-analysis. Additionally, a descriptive summary will be conducted for the functional response and secondary outcomes. DISCUSSION: No systematic review and meta-analysis on the treatment of ischaemic stroke through HDAC modulation has been conducted to date. A comprehensive analysis of the available literature on the relevant preclinical investigations can yield invaluable insights in discerning the most effective trials and in further standardisation of preclinical studies. SYSTEMATIC REVIEW REGISTRATION: This systematic review has been recorded in the International Prospective Register of Systematic Reviews (PROSPERO), with the assigned reference number: CRD42023381420.

Enhancing Wear Resistance of UHMWPE Composites with Micro MoS2 and Nano Graphite: A Taguchi-DOE Approach.

This study presents an in-depth investigation into the wear characteristics of ultrahigh-molecular-weight polyethylene (UHMWPE) composites reinforced with microsized MoS2 and nanosized graphite particles. The objective is to enhance the wear resistance of the UHMWPE by examining the effects of various parameters and optimizing the wear performance. To achieve this goal, wet wear tests were conducted under controlled conditions, and the results were compared between composites with micro MoS2 and nano graphite reinforcements. The Taguchi method was employed to design the experiments (DOE) using an L9 orthogonal array. Four key parameters, namely, reinforcement percentage, load, speed, and track radius, were varied systematically to analyze their impact on wear characteristics, including wear rate, frictional forces, and the coefficient of friction (COF). The data obtained from the experiments were subjected to analysis of variance (ANOVA) to identify the significant factors affecting wear behavior. Subsequently, the optimal wear parameters were determined through regression analysis, allowing for the prediction of wear characteristics under the optimum conditions. This research not only provides insights into the comparative performance of micro MoS2 and nano graphite reinforcements in UHMWPE composites but also offers a comprehensive approach to optimizing wear resistance by employing advanced statistical and experimental techniques. The findings contribute to the development of more durable and wear-resistant materials with potential applications in various industries, such as those investigated in the study, which are commonly employed, such as automotive, aerospace, medical devices, or manufacturing.

A density functional theory study on the potential application of Ni and Co doped ZnO nanosheets as a carrier for ciclopirox anticancer drug.

The Ni and Co doping effect on the ciclopirox (CPX) drug delivery performance of a ZnO nanosheet (ZnO-NS) was investigated theoretically. Doping Ni and Co metals into the ZnO-NS increased the adsorption energy of CPX from -7.9 to -27.4 and -31.7 kcal/mol, respectively. The CPX adsorption reduced the ZnO-NS gap (Eg) from 3.81 to 3.46 eV, while the CPX adsorption reduced the Eg of the Ni- and Co-doped ZnO-NS from 2.74 and 2.68 eV to 1.87 and 1.71 eV, respectively. The CPX adsorption performance increased after doping process. A drug release mechanism was introduced in cancerous tissues based on the PH. .

Stability risk assessment of slopes using logistic model tree based on updated case histories.

A new logistic model tree (LMT) model is developed to predict slope stability status based on an updated database including 627 slope stability cases with input parameters of unit weight, cohesion, angle of internal friction, slope angle, slope height and pore pressure ratio. The performance of the LMT model was assessed using statistical metrics, including accuracy (Acc), Matthews correlation coefficient (Mcc), area under the receiver operating characteristic curve (AUC) and F-score. The analysis of the Acc together with Mcc, AUC and F-score values for the slope stability suggests that the proposed LMT achieved better prediction results (Acc = 85.6%, Mcc = 0.713, AUC = 0.907, F-score for stable state = 0.967 and F-score for failed state = 0.923) as compared to other methods previously employed in the literature. Two case studies with ten slope stability events were used to verify the proposed LMT. It was found that the prediction results are completely consistent with the actual situation at the site. Finally, risk analysis was carried out, and the result also agrees with the actual conditions. Such probability results can be incorporated into risk analysis with the corresponding failure cost assessment later.

Estimating of gases emission from waste sites to generate electrical energy as a case study at Al-Hillah City in Iraq.

Methane (CH4) is a greenhouse gas resulting from human activities, especially landfills, and it has many potential environmental issues, such as its major role in global warming. On the other hand, methane can be converted to liquid fuel or electricity using chemical conversion or gas turbine generators. Therefore, reusing such gases could be of great environmental and economic benefit. In this context, this study aims to estimate the emissions of methane gas from the landfills in Al-Hillah City, Iraq, from 2023 to 2070 and the producible electric energy from this amount. The estimating process was carried out using the Land GEM model and compared with traditional models. The obtained results demonstrated that the total estimated landfill methane emissions for 48 years are 875,217 tons, and the average annual methane emission is 18,234 tons based on a yearly waste accumulation rate of 1,046,413 tons and a total waste amount of 50,227,808 tons. The anticipated loads of methane gas can be utilized to generate about 287,442 MW/year of electricity from 2023 to 2070. In conclusion, the results obtained from this study could be evidence of the potential environmental and economic benefits of harvesting and reusing methane gas from landfills.

Predicting California bearing ratio of HARHA-treated expansive soils using Gaussian process regression.

The California bearing ratio (CBR) is one of the basic subgrade strength characterization properties in road pavement design for evaluating the bearing capacity of pavement subgrade materials. In this research, a new model based on the Gaussian process regression (GPR) computing technique was trained and developed to predict CBR value of hydrated lime-activated rice husk ash (HARHA) treated soil. An experimental database containing 121 data points have been used. The dataset contains input parameters namely HARHA-a hybrid geometrical binder, liquid limit, plastic limit, plastic index, optimum moisture content, activity and maximum dry density while the output parameter for the model is CBR. The performance of the GPR model is assessed using statistical parameters, including the coefficient of determination (R2), mean absolute error (MAE), root mean square error (RMSE), Relative Root Mean Square Error (RRMSE), and performance indicator (ρ). The obtained results through GPR model yield higher accuracy as compare to recently establish artificial neural network (ANN) and gene expression programming (GEP) models in the literature. The analysis of the R2 together with MAE, RMSE, RRMSE, and ρ values for the CBR demonstrates that the GPR achieved a better prediction performance in training phase with (R2 = 0.9999, MAE = 0.0920, RMSE = 0.13907, RRMSE = 0.0078 and ρ = 0.00391) succeeded by the ANN model with (R2 = 0.9998, MAE = 0.0962, RMSE = 4.98, RRMSE = 0.20, and ρ = 0.100) and GEP model with (R2 = 0.9972, MAE = 0.5, RMSE = 4.94, RRMSE = 0.202, and ρ = 0.101). Furthermore, the sensitivity analysis result shows that HARHA was the key parameter affecting the CBR.

Recycling solid waste to produce eco-friendly ultra-high performance concrete: A review of durability, microstructure and environment characteristics.

Recycling waste materials (WMs) is a cost-effective method for saving natural resources, protecting the environment, and reducing the use of high-carbon raw materials. This review aims to illustrate the impact of solid waste on the durability and microstructure of ultra-high performance concrete (UHPC) and to provide guidance for the research of eco-friendly UHPC. The results show that the proper use of solid waste to replace part of the binder or aggregate has a positive effect on the performance development of UHPC, but further enhancement techniques should be developed. When solid waste is prepared as a binder, the durability of waste based UHPC can be effectively improved by grinding and activation. When solid waste is used as an aggregate, its rough surface, potential reactivity and internal curing effect are also beneficial to the improvement of UHPC performance. Since UHPC has a dense microstructure, it can effectively prevent the leaching of harmful elements (heavy metal ions) in solid waste. However, the effect of waste modification on the reaction products of UHPC needs to be further studied, and design methods and testing standards suitable for eco-friendly UHPCs should be developed. The use of solid waste in UHPC effectively reduces the carbon footprint of the mixture, which is beneficial to the development of cleaner production technologies.

Basalt Fiber Reinforced Concrete: A Compressive Review on Durability Aspects.

The creation of sustainable composites reinforced with natural fibers has recently drawn the interest of both industrial and academics. Basalt fiber (BF) stands out as the most intriguing among the natural fibers that may be utilized as reinforcement due to their characteristics. Numerous academics have conducted many tests on the strength, durability, temperature, and microstructure characteristics of concrete reinforced with BF and have found promising results. However, because the information is dispersed, readers find it problematic to assess the advantages of BF reinforced concrete, which limits its applications. Therefore, a condensed study that provides the reader with an easy route and summarizes all pertinent information is needed. The purpose of this paper (Part II) is to undertake a compressive assessment of basalt fiber reinforced concrete's durability features. The results show that adding BF significantly increased concrete durability. The review also identifies a research deficiency that must be addressed before BF is used in practice.

Application of nano remediation of mine polluted in acid mine drainage water using machine learning model.

Acid mine drainage (AMD) is the term used to describe drainage from coal mines with high sulfur-bearing rocks. The oxidative weathering of metal sulfides leads to AMD. The acidic environment corrodes more harmful compounds in the soil, which is spread throughout the working area. One such significant metal is copper, which is extracted in massive quantities from ores rich in sulfide. A copper-extraction resin might be created by combining diatomaceous earth (DE) particles with polyethyleneimine (PEI), which is shown to have great selectivity and affinity for copper. In this effort, PEI-DE particles' copper absorption level was examined by using synthetic and actual acid mine drainage samples at varied pH values. The findings of the copper uptake particles have been examined through the Support Vector Machine (SVM) model. Using the n-fold 14 cross-validation approach, the quantities of parameters and C are estimated to be 0.001 and 0.01, respectively. The SVM analysis was correct, and the findings indicated that copper could bind to the material efficiently and preferentially at pH 4. Subsequent water elution studies at a pH value of 1 confirmed the pH-reliant interaction between dissolved Cu and PEI by demonstrating full release of the adsorbed Cu. In this research, the copper absorption of PEI-DE particles from synthetic and genuine AMD specimens was studied based on several pH conditions. The findings suggest that copper may attach to the material effectively and preferentially at pH 4. Studies of filtering water at pH1 later confirmed that all of the adsorbed Cu was released. This shows that the interaction between PEI and dissolved Cu depends on PH.

A Study on Sustainable Concrete with Partial Substitution of Cement with Red Mud: A Review.

Every year, millions of tons of red mud (RDM) are created across the globe. Its storage is a major environmental issue due to its high basicity and tendency for leaching. This material is often kept in dams, necessitating previous attention to the disposal location, as well as monitoring and maintenance during its useful life. As a result, it is critical to develop an industrial solution capable of consuming large quantities of this substance. Many academics have worked for decades to create different cost-effective methods for using RMD. One of the most cost-effective methods is to use RMD in cement manufacture, which is also an effective approach for large-scale RMD recycling. This article gives an overview of the use of RMD in concrete manufacturing. Other researchers' backgrounds were considered and examined based on fresh characteristics, mechanical properties, durability, microstructure analysis, and environmental impact analysis. The results show that RMD enhanced the mechanical properties and durability of concrete while reducing its fluidity. Furthermore, by integrating 25% of RDM, the environmental consequences of cumulative energy demand (CED), global warming potential (GWP), and major criteria air pollutants (CO, NOX, Pb, and SO2) were minimized. In addition, the review assesses future researcher guidelines for concrete with RDM to improve performance.

Source, toxicity and carcinogenic health risk assessment of heavy metals.

Heavy metals are chemical elements with unique properties that are toxic even in low concentrations and affect human health with different functions. Agricultural and industrial activities, improper disposal of household solid waste and residues related to industrial producers, discharge of household wastewater and agricultural fertilizers are the most important ways in which toxic heavy metals enter the environment, which harms human health and life. A narrative review of the literature was done from 2000 to 2022 based on searched databases included Google Scholar, PubMed, Springer, Web of Science, and Science Direct (Scopus). All relevant studies published 2000 until 2022 gathered. According to the databases, 820 articles were retrieved. 186 and 50 articles were found and selected based on records identified through database searching and additional records identified through other sources. In the next stage, 97 studies were screened after review and 64 full-text articles entered into the analysis process. Finally, 45 articles were selected in this study. Adverse effects of heavy metals on various conditions in the body depend on a number of factors, including dose, route of exposure and chemical species, as well as age, sex, genetics, nutritional status, and duration of exposure to the heavy metal. The existence of significant relationships between long-term and short-term exposure to toxic heavy metals and their adverse effects, including carcinogenicity, has been extensively studied and proven through numerous experiments. However, the mechanisms associated with this complication have not been properly identified, so in future research, there is a great need for comprehensive studies on the carcinogenicity of heavy metals.

Compaction Curves and Strength of Clayey Soil Modified with Micro and Nano Silica.

Some Clayey soils are generally categorized as weak soils, and structures lying on such soils have been exposed to severe damage. Therefore, the central thesis of this paper is the impact of a waste material known as a silica fume as nano and micro material on soil's behaviour. To evaluate the effects of those additives on Atterberg limits, compaction characteristics and unconfined compressive strength, clayey soil samples have been transformed using micro and nano silica fume (by-product materials). In the current investigation, silica fume is used at four different percentages: 0, 2, 4, and 7%. The results show that the plasticity index of soil decreases with the addition of micro silica and increases with the addition of nano-silica. Increasing nano silica percentage improves the dry density of the compacted soil and reduces the optimum moisture content. An opposite behavior is observed with adding micro silica to compacted soil. Finally, 4% of silica fume is found to be the optimum dosage to improve the unconfined compressive strength of the treated soil with both additives. As a result, treating the weak clay soil with micro and/or nano-silica fume has the potential to be impactful.

A Review on Strength and Durability Properties of Wooden Ash Based Concrete.

The partial replacement of cement in concrete with other building materials has come to light because of research on industrial waste and sustainable building practices. Concrete is made more affordable by using such components, and it also helps to ease disposal worries. Ash made by burning wood and other wood products is one example of such a substance. Many researchers focused on the utilization of wooden ash (WA) as a construction material. However, information is scattered, and no one can easily judge the impact of WA on concrete properties which restrict its use. Therefore, a details review is required which collect the past and current progress on WA as a construction material. relevant information. This review aims to collect all the relevant information including the general back of WA, physical and chemical aspects of WA, the impact of WA on concrete fresh properties, strength properties, and durability aspects in addition to microstructure analysis. The results indicate the WA decreased the slump and increased the setting time. Strength and durability properties improved with the substitution of WA due to pozzolanic reaction and micro-filling effects. However, the optimum dose is important. Different research recommends different optimum doses depending on source mix design etc. However, the majority of researcher suggests a 10% optimum substitution of WA. The review also concludes that, although WA has the potential to be used as a concrete ingredient but less researchers focused on WA as compared to other waste materials such as fly ash and silica fume etc.

Basalt Fibers Reinforced Concrete: Strength and Failure Modes.

The low tensile capacity of concrete often results in brittle failure without any warning. One way to cope with this issue is to add fibers and essentially improve the tensile strength (TS) behavior of concrete and offset its undesirable brittle failure. In recent investigations, basalt fibers (BFs), as compared to a variety of other kinds of fiber, have attracted the attention of researchers. In that respect, BFs exhibit several benefits, such as excellent elastic properties, great strength, high elastic modulus, higher thermal stability, and decent chemical stability. Although many researchers have reported that BFs can be embedded in concrete to improve the tensile capacity, a more profound understanding of its contribution is still needed. However, the information is scattered and it is difficult for the reader to identify the benefits of BFs. Therefore, a detailed assessment is essential to summarize all relevant information and provide an easy path for the reader. This review (part Ⅰ) summarizes all the relevant information, including flow properties, strength properties, and failure modes. Results reveal that BFs can greatly enhance the strength properties and change the brittle nature of concrete to one of ductility. However, it unfavorably impacts the flowability of concrete. Furthermore, the optimal proportion is shown to be important as a higher dose can adversely affect the strength of concrete, due to a deficiency of flowability. The typical range of the ideal incorporation of BFs varies from 0.5 to 1.5%. Finally, the review also indicates the research gap for future research studies that must be cautiously explored before being used in the real world.

Concrete Made with Dune Sand: Overview of Fresh, Mechanical and Durability Properties.

According to the authors' best information, the majority of research focuses on other waste materials, such as recycling industrial waste (glass, silica fume, marble and waste foundry sand), etc. However, some researchers suggest dune sand as an alternative material for concrete production, but knowledge is still scarce. Therefore, a comprehensive review is required on dune sand to evaluate its current progress as well as its effects on the strength and durability properties of concrete. The review presents detailed literature on dune sand in concrete. The important characteristics of concrete such as slump, compressive, flexural, cracking behaviors, density, water absorption and sulfate resistance were considered for analysis. Results indicate that dune sand can be used in concrete up to 40% without any negative effect on strength and durability. The negative impact of dune sand on strength and durability was due to poor grading and fineness, which restricts the complete (100%) substation of dune sand. Furthermore, a decrease in flowability was observed. Finally, the review highlights the research gap for future studies.

Concrete Made with Iron Ore Tailings as a Fine Aggregate: A Step towards Sustainable Concrete.

The need for low-cost raw materials is driven by the fact that iron ore tailings, a prevalent kind of hazardous solid waste, have created major environmental issues. Although many studies have focused on using iron ore tailing (IOT) in concrete and have reported positive results, readers may find it difficult to accurately assess the behaviors of IOT in concrete due to the scattered nature of the information. Therefore, a comprehensive assessment of IOT in concrete is necessary. This paper thoroughly reviews the characteristics of concrete that contains IOT such as fresh properties, mechanical properties and durability at different age of curing. The outcome of this review indicates that by using IOT, concrete's mechanical properties and durability improved, but its flowability decreased. Compressive strength of concrete with 20% substitution of IOT is 14% more than reference concrete. Furthermore, up to 40% substitution of IOT produces concrete that has sufficient flowability and compactability. Scan electronic microscopy results indicate a weak interfacial transition zone (ITZ). The optimum IOT dosage is important since a greater dose may decrease the strength properties and durability owing to a lack of fluidity. Depending on the physical and chemical composition of IOT, the average value of optimum percentages ranges from 30 to 40%. The assessment also recommends areas of unsolved research for future investigations.

Overview of Concrete Performance Made with Waste Rubber Tires: A Step toward Sustainable Concrete.

Utilizing scrap tire rubber by incorporating it into concrete is a valuable option. Many researchers are interested in using rubber tire waste in concrete. The possible uses of rubber tires in concrete, however, are dispersed and unclear. Therefore, a compressive analysis is necessary to identify the benefits and drawbacks of rubber tires for concrete performance. For examination, the important areas of concrete freshness, durability, and strength properties were considered. Additionally, several treatments and a microstructure investigation were included. Although it has much promise, there are certain obstacles that prevent it from being used as an aggregate in large numbers, such as the rubber's weak structural strength and poor binding performance with the cement matrix. Rubber, however, exhibits mechanical strength comparable to reference concrete up to 20%. The evaluation also emphasizes the need for new research to advance rubberized concrete for future generations.

Remediation of mine polluted soil with nano-enhanced materials: Development of extreme learning machine approaches.

Successful mining soil reclamation promotes ecosystem recovery, reduces negative environmental effects, adds more area for forestry or agricultural purposes, and increases carbon (C) sequestration. In order to increase soil erosion management, improve soil quality, reduce pollutants, and assure safe land application of traditional amendment materials, nanoparticles with exceptionally high deliverability and reactivity may be used as amendments. Iron oxide is being researched for the remediation of industrial soil that is co-contaminated with arsenic (AS) due to the absence of Nano enhanced materials for mine soil reclamation. In order to improve the soil quality of a mine waste that was heavily polluted with As (1807 mg/kg), the effects of iron oxide on the non-specifically and specifically-sorbed As were investigated. Iron oxide was added to the polluted soil at concentrations of 0.5 percent, 2 percent, and 5 percent (w/w). The goal of this work is to define the effect of iron oxide and Zero Valent I nanoparticles (nZVI) in reducing the contamination of soil by the use of soft computing models of extreme learning machines (ELM) with particle swarm optimization (PSO). In this case, the hybrid ELM-PSO has shown good performance as a trustworthy approach after the regression study of RMSE, R-square, and r. The addition of iron oxide dosages decreased the easily accessible As by 92.4 when compared to the untreated soil, with the 5 percent doses having a noticeably greater effect.

Aptamer Based Nanoprobes for Detection of Foodborne Virus in Food and Environment Samples: Recent Progress and Challenges.

Accepting the fact that there is a huge number of virus particles in food that lead to several infectious diseases, eliminating of the foodborne virus from food is tangible. In 2020, the appearance of new SARS-CoV-2 variants had remarked the importance of food safety in our lives. Detection virus is a dynamic domain. Recently, many papers have tried to detect several foodborne viruses by using conventional sensing platforms including ELISA (enzyme-linked immunosorbent assay), PCR (polymerase chain reaction-based methods) and NASBA (nucleic acid sequence-based amplification). However, small sizes, low infective doses and discrete distribution of the foodborne virus have converted these microorganisms into the most challengeable pathogen in the food samples matrix. Foodborne virus detection exploiting aptamer-based biosensors has attracted considerable attention toward the numerous benefits of sourcing from aptamers in which a variety of viruses could be detected by conjugation of aptamer-virus. The development of multiple sensing methodologies and platforms in terms of aptasensor application in real food and environment samples has demonstrated promising results. In this review, we present the latest developments in myriad types of aptasensors (including electrochemical, optical and piezoelectric aptasensor) for the quantification of foodborne viruses. Working strategies, benefits and disadvantages of these platforms are argued.