ABSTRACT
The efficiency of terbinafine was tested in C57BL/6 mice inoculated with the Leishmania (Leishmania) amazonensis strain MHOM/BR/PH8. The mice were administered: terbinafine at a dose of 100mg/kg/d by via oral; 0.9% saline solution orally as the control; and subcutaneous sodium stibogluconate 400mg SbV/kg/d as gold standard, for 20 days. Terbinafine was demonstrated to be ineffective when compared to the controls, using clinical and parasitological parameters and the limiting dilution assay.
Subject(s)
Antimony Sodium Gluconate/therapeutic use , Antiprotozoal Agents/therapeutic use , Enzyme Inhibitors/therapeutic use , Leishmaniasis, Cutaneous/drug therapy , Naphthalenes/therapeutic use , Animals , Disease Models, Animal , Drug Evaluation, Preclinical , Male , Mice , Mice, Inbred C57BL , TerbinafineABSTRACT
Testou-se, em camundongos C57BL/6 inoculados com a cepa MHOM/BR/PH8 de Leishmania (Leishmania) amazonensis, terbinafina via oral 100mg/kg/dia, por 20 dias, soluçäo salina 0,9 por cento via oral como controle e stibogluconato de sódio 400mg SbV/kg/dia via subcutânea como padräo-ouro. A terbinafina mostrou-se ineficaz, clínica e parasitologicamente, e pelo ensaio por diluiçäo limitante, quando comparada aos controles
