ABSTRACT
BACKGROUND: In plastic surgery, guidelines about antibiotic prophylaxis are inaccurate and incomplete, due to result the absence of high-level studies on this subject. The main aim is to establish national common recommendations for plastic surgery antibiotic prophylaxis. MATERIALS AND METHODS: A working group will discuss and validate a multi-center analysis of practices in three University Hospital Centers compared to an interdisciplinary analysis of recommendations to the French Society of Anaesthesia and Intensive Care Medicine and scientific literature. This working group is composed of plastic surgeon members of the French Society of Aesthetic Reconstructive Plastic Surgery, infectious disease physicians, and anaesthesiologists to define clear and precise antibiotic prophylaxis recommendations. RESULTS: Antibiotic prophylaxis with cefazoline (or clindamycine±gentamicine in case of allergy), has been recommended for general surgery with flap or implants, for breast surgery, lipofilling, and rhinoplasty. In other plastic surgery, no antibiotic prophylaxis has been recommended. CONCLUSION: We established common recommendations for plastic surgery antibiotic prophylaxis that is the first step to update these recommendations. Now, they can be evaluated in clinical situation to validate them.
Subject(s)
Antibiotic Prophylaxis , Plastic Surgery Procedures , Practice Guidelines as Topic , Surgery, Plastic , France , Humans , Multicenter Studies as Topic , Societies, MedicalSubject(s)
Anesthesia, General/adverse effects , Drug Hypersensitivity/diagnosis , Neuromuscular Blocking Agents/adverse effects , Adolescent , Adult , Aged , Female , Humans , Intraoperative Complications/chemically induced , Male , Middle Aged , Postoperative Complications/chemically induced , Recurrence , Skin TestsSubject(s)
Cesarean Section/adverse effects , Echocardiography, Doppler , Fontan Procedure/adverse effects , Hemodynamic Monitoring/methods , Monitoring, Intraoperative/methods , Adult , Anesthesia, Epidural/methods , Anesthesia, Obstetrical/methods , Anesthesia, Spinal/methods , Female , Heart Defects, Congenital/surgery , Hemodynamic Monitoring/instrumentation , Humans , PregnancySubject(s)
Disseminated Intravascular Coagulation/etiology , Placenta Accreta/physiopathology , Placenta, Retained/physiopathology , Postoperative Complications/etiology , Adult , Body Mass Index , Cesarean Section/adverse effects , Cesarean Section, Repeat/adverse effects , Conservative Treatment/adverse effects , Female , Humans , Hysterectomy , Obesity/complications , Obesity/physiopathology , Placenta Accreta/diagnostic imaging , Placenta Accreta/surgery , Placenta, Retained/diagnostic imaging , Placenta, Retained/surgery , Pregnancy , Pregnancy Complications/physiopathology , Treatment Outcome , Ultrasonography, PrenatalABSTRACT
OBJECTIVE: To evaluate the implementation of a protocol of enhanced recovery for elective cesarean section in a level III maternity. METHODS: This is a prospective observational study such as "before/after" on the implementation of a protocol of enhanced recovery for elective cesarean section from January 1st to December 31st, 2015, in a level III obstetrics unit French maternity. Patients were separated in 2 groups: women who benefit from enhanced recovery protocol after the first of July compared to women who underwent the conventional protocol between January 1st and June 30th, 2015. Inclusion criteria included: performing an emergency or scheduled cesarean, in patients with medical history congruent with the possible hospital release at day three. Demographic and obstetrics data were gathered. Items of the protocol, adverse and secondary effects as well as, postoperative complications were collected. RESULTS: From January 1st to December 31st 2015, 408 patients were included in this study, 202 in the conventional arm protocol and 206 in the enhanced recovery protocol. Early rehabilitation protocol has been achieved for 25.7 % patients (n=105) with 18.1 % (n=19) before the establishment of the protocol and 81.9 % (n=86) after creation of the latter. Prevention of PONV by dexamethasone and droperidol was performed before and after creation of the protocol in 5.3 % (n=1) and 51.2 % of cases (n=44) (P<0.05), respectively. There were no significant differences between the 2 groups regarding the removal of the urinary catheter (94.7 % versus 76 %, P=0.14) or the shutter venous catheter SSPI (78.9 % vs 73 %, P=0.82). Administration of drinks H1 and H4 first meal were routinely performed after the creation of the protocol (52.6 % vs 100 %, P<0.05 and 63.1 % vs 100 %, P<0.05). An early rise in the first 12hours was usually performed after the drafting of the protocol (78.9 % versus 92 %, P<0.05). Average hospital stay was shorter after the establishment of early rehabilitation protocol (4 versus 5.5 days, P<0.05). CONCLUSION: Early rehabilitation protocol was applied safely. It resolved in good management of pain, nausea and vomiting in postoperative. It participated in reducing adverse outcomes that could slow recovery and therefore allowed earlier hospital discharge, while maintaining high level of satisfaction with their care.
Subject(s)
Cesarean Section/rehabilitation , Elective Surgical Procedures/rehabilitation , Postoperative Care/methods , Female , Humans , Length of Stay , Nausea/prevention & control , Pain Management , Postoperative Complications/epidemiology , Postoperative Complications/prevention & control , Pregnancy , Prospective Studies , Vomiting/prevention & controlABSTRACT
BACKGROUND: Immediate hypersensitivity reactions during anaesthesia are rare but potentially life-threatening. The epidemiology changes with time and evolving professional practice, and hence needs to be monitored. Our objective was to follow this epidemiology. METHODS: This was a retrospective, observational study in French hospital clinics, conducted by GERAP members (Groupe d'Étude des Réactions Anaphylactoïdes Périopératoires). Consecutive patients seen in allergo-anaesthesia outpatient clinics, who had experienced a hypersensitivity reaction during anaesthesia between 1 January 2011 and 31 December 2012, were included. Demographic data, allergy history, drugs received before the reaction, symptoms of the reaction, results of blood samples (histamine, tryptase, IgE-specific assays), and results of the allergy assessment were recorded. RESULTS: The most common causes of allergic reactions were (Neuromuscular Blocking Agents) NMBAs (N = 302; 60.6%), antibiotics (N = 91, 18.2%, Cephalosporin N = 49, 10%) and dyes (N = 27; 5.4%). Latex as an allergic agent was involved in 26 cases (5.2%), hypnotics in 11 cases (2.2%) and opioids in seven cases (1.4%). Of the NMBAs, Rocuronium had the highest proportion of reactions (13.8 reactions/100,000 vials sold) followed by Suxamethonium (13.3/100,000 vials sold). Cisatracurium had the lowest proportion of reactions (0.4/100,000 vials sold). Patients were sensitized to two or more NMBAs in 48.9% of cases and without testing, cross-sensitivity cannot be predicted. CONCLUSIONS: When compared with the previous GERAP studies, NMBAs are still the most frequently triggering allergens, with marked differences between individual NMBAs, but they are now followed by antibiotics (of which greater than 50% were cephalosporins) and dyes. Anaesthetists must be aware of the differences between drugs and of the pattern of emerging allergens. For the future of safe anaesthesia, allergy assessment is essential.
Subject(s)
Anesthesia/adverse effects , Drug Hypersensitivity/epidemiology , Anti-Bacterial Agents/adverse effects , Female , France/epidemiology , Histamine/blood , Humans , Immunoglobulin E/blood , Male , Neuromuscular Blocking Agents/adverse effects , Retrospective Studies , Time Factors , Tryptases/bloodABSTRACT
BACKGROUND: Vasopressor administration is recommended to prevent hypotension during spinal anaesthesia (SA) for elective Caesarean delivery. We aimed to test the superior efficacy and ensure safety of a hydroxyethyl starch (HES) vs a Ringer's lactate (RL) preloading, when combined with a phenylephrine-based prophylaxis. METHODS: A total of 167 healthy parturients undergoing elective Caesarean delivery under SA were included in this multicentre, randomized, double-blind study. Patients received 500 ml of 6% HES (130/0.4)+500 ml of RL (HES group) or 1000 ml of RL (RL group) i.v. before SA. After SA, i.v. phenylephrine boluses were titrated when systolic arterial pressure (SAP) was below 95% of baseline. The primary outcome was the incidence of maternal hypotension (SAP <80% of baseline). RESULTS: The incidence of both hypotension and symptomatic hypotension (i.e. with dizziness, nausea/vomiting, or both) was significantly lower in the HES group vs the RL group: 36.6% vs 55.3% (one-sided P=0.025) and 3.7% vs 14.1%. There was no significant difference in total phenylephrine requirements [median (range): 350 (50-1800) vs 350 (50-1250) µg]. The decrease in maternal haemoglobin value the day after surgery was similar in the two groups [1.2 (1.0) vs 1.0 (0.9) g dl(-1)]. There was no detectable placental transfer of HES in six umbilical cord blood samples analysed in the HES group. Neonatal outcomes were comparable between the groups. CONCLUSIONS: Compared with a pure RL preloading, a mixed HES-RL preloading significantly improved prevention of both hypotension and symptomatic hypotension based on early phenylephrine bolus administration and did not induce adverse effects. CLINICAL TRIAL REGISTRATION: NCT00694343 (http://clinicaltrials.gov).
Subject(s)
Anesthesia, Obstetrical/methods , Anesthesia, Spinal/methods , Cesarean Section/methods , Hydroxyethyl Starch Derivatives/administration & dosage , Hypotension/prevention & control , Isotonic Solutions/administration & dosage , Preanesthetic Medication/methods , Adult , Anesthesia, Obstetrical/adverse effects , Anesthesia, Spinal/adverse effects , Blood Pressure/drug effects , Double-Blind Method , Female , Humans , Hypotension/chemically induced , Middle Aged , Phenylephrine/therapeutic use , Plasma Substitutes/therapeutic use , Ringer's Lactate , Treatment Outcome , Vasoconstrictor Agents/therapeutic use , Young AdultABSTRACT
Respiratory complications of blood transfusion have several possible causes. Transfusion-Associated Circulatory Overload (TACO) is often the first mentioned. Transfusion-Related Acute Lung Injury (TRALI), better defined since the consensus conference of Toronto in 2004, is rarely mentioned. French incidence is low. Non-hemolytic febrile reactions, allergies, infections and pulmonary embolism are also reported. The objective of this work was to determine the statistical importance of the different respiratory complications of blood transfusion. This work was conducted retrospectively on transfusion accidents in six health centers in Champagne-Ardenne, reported to Hemovigilance between 2000 and 2009 and having respiratory symptoms. The analysis of data was conducted by an expert committee. Eighty-three cases of respiratory complications are found (316,864 blood products). We have counted 26 TACO, 12 TRALI (only 6 cases were identified in the original investigation of Hemovigilance), 18 non-hemolytic febrile reactions, 16 cases of allergies, 5 transfusions transmitted bacterial infections and 2 pulmonary embolisms. Six new TRALI were diagnosed previously labeled TACO for 2 of them, allergy and infection in 2 other cases and diagnosis considered unknown for the last 2. Our study found an incidence of TRALI 2 times higher than that reported previously. Interpretation of the data by a multidisciplinary committee amended 20% of diagnoses. This study shows the imperfections of our system for reporting accidents of blood transfusion when a single observer analyses the medical records.
Subject(s)
Blood Safety/statistics & numerical data , Lung/pathology , Respiratory Tract Diseases/etiology , Transfusion Reaction , France/epidemiology , Humans , Incidence , Respiratory Tract Diseases/epidemiology , Retrospective StudiesABSTRACT
Acute postoperative negative pressure pulmonary edema with hemoptysia as a complication of general anesthesia is seldom. Its is related to an obstacle on airway, with important negative intrathoracic depression during inspiration leading to pulmonary edema and hemoptysia. Physiopathology and treatment of such complication have been discussed.
Subject(s)
Anesthesia, General/adverse effects , Hemoptysis/etiology , Pulmonary Edema/etiology , Tonsillectomy/adverse effects , Hemoptysis/therapy , Humans , Male , Postoperative Complications/therapy , Pulmonary Edema/therapy , Young AdultABSTRACT
Anaphylactic shock is a rare, but potentially lethal complication, combining life-threatening circulatory failure and massive fluid shifts. Treatment guidelines rely on adrenaline and volume expansion by intravenous fluids, but there is no solid evidence for the choice of one specific type of fluid over another. Our purpose was to compare the time to achieve target mean arterial pressure upon resuscitation using adrenaline alone versus adrenaline with different resuscitation fluids in an animal model and to compare the tissue oxygen pressures (PtiO2) with the various strategies. Twenty-five ovalbumin-sensitised Brown Norway rats were allocated to five groups after anaphylactic shock induction: vehicle (CON), adrenaline alone (AD), or adrenaline with isotonic saline (AD+IS), hydroxyethyl starch (AD+HES) or hypertonic saline (AD+HS). Time to reach a target mean arterial pressure value of 75 mmHg, cardiac output, skeletal muscle PtiO2, lactate/pyruvate ratio and cumulative doses of adrenaline were recorded. Non-treated rats died within 15 minutes. The target mean arterial pressure value was reached faster with AD+HES (median: 10 minutes, range: 7.5 to 12.5 minutes) and AD+IS (median: 17.5 minutes, range: 5 to 25 minutes) versus adrenaline alone (median: 25 minutes, range: 20-30 minutes). There were also reduced adrenaline requirements in these groups. The skeletal muscle PtiO2 was restored only in the AD+HES group. Although direct extrapolation to humans should be made with caution, our results support the combined use of adrenaline and volume expansion for resuscitation from anaphylactic shock. When used with adrenaline the most effective fluid was hydroxyethyl starch, whereas hypertonic saline was the least effective.
Subject(s)
Anaphylaxis/therapy , Arterial Pressure/drug effects , Epinephrine/therapeutic use , Plasma Substitutes/therapeutic use , Resuscitation/methods , Adrenergic alpha-Agonists/therapeutic use , Animals , Cardiac Output/drug effects , Colloids/therapeutic use , Disease Models, Animal , Drug Therapy, Combination/methods , Fluid Therapy/methods , Hydroxyethyl Starch Derivatives/therapeutic use , Isotonic Solutions , Microdialysis/methods , Rats , Saline Solution, Hypertonic/therapeutic use , Time FactorsABSTRACT
The causes of hemodynamic instability in acute pancreatitis are numerous. Although pericardial effusion during pancreatitis is common, a cardiac tamponade is rarely reported. The diagnosis of compressive cardiac disorders (CDD) by echocardiography is easily reported when the patient is breathing spontaneously; it becomes difficult when the patient is assisted with positive pressure ventilation.
Subject(s)
Cardiac Tamponade/complications , Cardiac Tamponade/diagnosis , Pancreatitis/complications , Positive-Pressure Respiration , Shock/diagnosis , Shock/etiology , Adult , Cardiac Tamponade/diagnostic imaging , Drainage , Echocardiography, Doppler , Fatal Outcome , Female , Hemodynamics/physiology , Humans , Mitral Valve/diagnostic imaging , Multiple Organ Failure/complications , Multiple Organ Failure/therapy , Pericardial Effusion/therapy , Vasoplegia/etiologySubject(s)
Conversion Disorder/psychology , Postoperative Complications/psychology , Spine/surgery , Vision Disorders/etiology , Vision Disorders/psychology , Anesthesia, Intravenous , Female , Fundus Oculi , Humans , Magnetic Resonance Imaging , Orthopedic Procedures , Scoliosis/surgery , Vision Disorders/diagnosis , Young AdultABSTRACT
OBJECTIVE: To review the current research and formulate a rational approach to the physiopathology, cause and treatment of post-dural puncture headache (PDPH). DATA SOURCES: Articles published to December 2011 were obtained through a search of Medline for the MeSh terms "epidural blood-patch" and "post-dural puncture headache". STUDY SELECTION: Six hundred and eighty-two pertinent studies were included and 200 were analysed. DATA SYNTHESIS: Resulting of a dural tap after spinal anaesthesia or diagnostic lumbar puncture or as a complication of epidural anaesthesia, PDPH occurs when an excessive leak of cerebrospinal fluid leads to intracranial hypotension associated to a resultant cerebral vasodilatation. Reduction in cerebrospinal fluid volume in upright position may cause traction of the intracranial structure and stretching of vessels. Typically postural, headache may be associated to nausea, photophobia, tinnitus or arm pain and changes in hearing acuity. In severe cases, there may be cranial nerve dysfunction and nerve palsies secondary to traction on those nerves. The Epidural Blood-Patch (EBP) is considered as the "gold standard" in the treatment of PDHP because it induces a prolonged elevation of subarachnoid and epidural pressures, whereas such elevation is transient with saline or dextran. EBP should be performed within 24-48hours of onset of headache; the optimum volume of epidural blood appears to be 15-20mL. Severe complications following EBP are exceptional. The use of echography may be safety puncture. The optimum timing of epidural blood-patch, the resort of repeating procedure if the symptomatology does not disappear, the alternative to the conventional medical treatment need to be determined by future clinical trial.
Subject(s)
Blood Patch, Epidural , Post-Dural Puncture Headache/therapy , Anesthesia, Epidural/adverse effects , Anesthesia, Spinal/adverse effects , Blood Patch, Epidural/adverse effects , Blood Patch, Epidural/methods , Cerebrospinal Fluid/physiology , Cerebrovascular Circulation , Cranial Nerve Diseases/etiology , Cranial Nerve Diseases/physiopathology , Diagnosis, Differential , Epidural Space , Headache/diagnosis , Hearing Loss, Sensorineural/etiology , Hearing Loss, Sensorineural/physiopathology , Hematoma, Subdural, Intracranial/etiology , Hematoma, Subdural, Intracranial/physiopathology , Humans , Intracranial Hypotension/etiology , Intracranial Hypotension/physiopathology , Meta-Analysis as Topic , Neuroimaging , Post-Dural Puncture Headache/cerebrospinal fluid , Post-Dural Puncture Headache/complications , Post-Dural Puncture Headache/diagnosis , Post-Dural Puncture Headache/epidemiology , Post-Dural Puncture Headache/physiopathology , Posture , Randomized Controlled Trials as Topic , Risk Factors , VasodilationABSTRACT
We report two cases of inadvertent peripheral nerve catheter (PNC) shearing that occurred during placement under ultrasound guidance. Same PNC kits were used in two different hospitals. The possible causes of PNC shearing are exposed. Differences and mechanical properties of different PNC kits are discussed. The management of retained PNC carried out in these cases is presented.
Subject(s)
Catheterization, Peripheral/instrumentation , Catheters , Femoral Nerve , Foreign Bodies/etiology , Intraoperative Complications/etiology , Nerve Block/instrumentation , Ultrasonography, Interventional , Adolescent , Aged , Analgesia, Patient-Controlled , Analgesics/administration & dosage , Analgesics/therapeutic use , Anterior Cruciate Ligament/surgery , Arthroplasty, Replacement, Knee , Equipment Design , Equipment Failure , Female , Femoral Nerve/diagnostic imaging , Femoral Nerve/physiology , Foreign Bodies/diagnostic imaging , Humans , Imaging, Three-Dimensional , Intraoperative Complications/diagnostic imaging , Male , Monitoring, Intraoperative , Pain, Postoperative/drug therapy , Pain, Postoperative/prevention & control , Pain, Postoperative/therapy , RadiographyABSTRACT
"Transfusion-related acute lung injury" (TRALI) is a post-transfusion lesional pulmonary edema, potentially severe, better defined since the conference of Toronto in 2004. The incidence of TRALI reported in France remains low in part because of its ignorance by physicians. The objective of our study was to evaluate retrospectively transfusion accidents with respiratory complications that occurred in Nancy University Hospital and reported to the haemovigilance between 1996 and 2006, from the software "Traceline" listing all the blood transfusion complications from signs observed. The analysis of the files has been performed by applying rigorously diagnostic criteria of Toronto. Forty-one cases of respiratory complications were found in 34,573 blood products. Ten cases of TRALI were diagnosed while only one case had been reported to the haemovigilance. The remaining nine cases were previously labeled transfusion-associated circulatory overload (TACO). No cases of TRALI have been identified in the ICU. Our work can find an incidence of TRALI 10 times greater than previously reported. Ignorance of TRALI and the lack of consensus definition before 2004 are not sufficient to explain these results. This study demonstrates the potential interest of database and computerized declaration system based on the symptoms observed. It highlights the vulnerability of the current haemovigilance too dependent on a single medical observer. Although TRALI are recognized as serious complications, sometimes requiring resuscitative care, our work was not isolated severe TRALI in ICU. Physician awareness of TRALI to the identification and to the declaration, including ICU should be continued. Finally, the diagnostic criteria for TRALI must be adapted to the ICU.
Subject(s)
Acute Lung Injury/epidemiology , Blood Safety/statistics & numerical data , Lung/pathology , Pulmonary Edema/epidemiology , Transfusion Reaction , Acute Lung Injury/etiology , France/epidemiology , Hospitals, University , Humans , Incidence , Pulmonary Edema/etiology , Retrospective StudiesABSTRACT
BACKGROUND: An increasing number of immediate hypersensitivity reactions (HSR) have been reported after the use of Patent Blue V (PBV) for breast cancer surgery. This is the first study to publish prospective data with systematic allergological assessment. METHODS: We conducted a multicentre study in 10 French cancer centres for over 6 months. All patients scheduled for breast surgery with injection of PBV were included in the study. Patients were screened for past medical history, atopy, and known food and drug allergies. When suspected HSR or unexplained reactions occurred after injection of PBV, blood samples were taken, and plasma histamine and serum tryptase concentrations were measured. HSR to PBV was suggested if skin tests performed 6 weeks later were positive. RESULTS: Nine suspected HSR to PBV were observed in 1742 patients. Skin tests were positive in six patients, giving an incidence of 0.34%. Four grade I and two grade III HSR were observed, both requiring intensive care unit treatment. Mean onset time of the reaction was 55 ± 37 min. Plasma histamine was elevated in four patients, while serum tryptase was normal. We found no risk factors associated with HSR to PBV. CONCLUSION: An incidence rate of one in 300 HSR to PBV was observed for patients exposed to PBV during sentinel lymph node detection. This rate is higher than rates reported after the use of neuromuscular blocking agents, latex or antibiotics.
Subject(s)
Breast Neoplasms/surgery , Coloring Agents/adverse effects , Drug Hypersensitivity/epidemiology , Intraoperative Complications/epidemiology , Rosaniline Dyes/adverse effects , Aged , Anesthesia, General , Drug Hypersensitivity/diagnosis , Female , France/epidemiology , Histamine/blood , Humans , Intraoperative Complications/diagnosis , Middle Aged , Prospective Studies , Risk Factors , Sentinel Lymph Node Biopsy/adverse effects , Skin Tests , Treatment Outcome , Tryptases/bloodSubject(s)
Anesthesia, Epidural/adverse effects , Anesthesia, Spinal/adverse effects , Ependymoma/complications , Paraplegia/diagnosis , Paraplegia/etiology , Spinal Cord Neoplasms/complications , Adult , Ependymoma/diagnosis , Female , Humans , Incidental Findings , Paraplegia/chemically induced , Pregnancy , Puerperal Disorders/diagnosis , Puerperal Disorders/etiology , Spinal Cord Neoplasms/diagnosisSubject(s)
Anesthesia, Epidural , Anesthesia, Obstetrical , Anesthetics, Local/adverse effects , Coma/drug therapy , Fat Emulsions, Intravenous/therapeutic use , Hypotension/drug therapy , Lidocaine/adverse effects , Anesthetics, Local/administration & dosage , Anesthetics, Local/antagonists & inhibitors , Anesthetics, Local/blood , Anesthetics, Local/pharmacokinetics , Bupivacaine/administration & dosage , Bupivacaine/adverse effects , Bupivacaine/analogs & derivatives , Bupivacaine/antagonists & inhibitors , Bupivacaine/blood , Bupivacaine/pharmacokinetics , Cesarean Section , Coma/chemically induced , Fat Emulsions, Intravenous/administration & dosage , Fat Emulsions, Intravenous/pharmacology , Female , Humans , Hydrophobic and Hydrophilic Interactions , Hypotension/chemically induced , Levobupivacaine , Lidocaine/administration & dosage , Lidocaine/antagonists & inhibitors , Lidocaine/blood , Lidocaine/pharmacokinetics , Nystagmus, Pathologic/chemically induced , Nystagmus, Pathologic/drug therapy , Phenylephrine/therapeutic use , Pregnancy , Tremor/chemically induced , Tremor/drug therapySubject(s)
Fibrinolytic Agents/adverse effects , Hematoma/etiology , Nerve Block/adverse effects , Polysaccharides/adverse effects , Sciatic Nerve , Thigh/injuries , Adult , Anesthesia, Conduction , Female , Fondaparinux , Hallux Valgus/surgery , Hematoma/diagnostic imaging , Hematoma/therapy , Humans , Pain, Postoperative/therapy , UltrasonographyABSTRACT
BACKGROUND: Hypersensitivity reactions occurring during anesthesia remain a major cause of concern for anesthesiologists. We report the results of the ninth consecutive survey of hypersensitivity reactions observed during anesthesia in France. This report will be used as an epidemiologic reference prior to this intervention. METHODS: Between January 1, 2005 to December 31, 2007, 1253 patients who experienced an immune-mediated (IgE-mediated) or non-immune-mediated (non-IgE-mediated) hypersensitivity reaction were referred to one of the 40 participating centers. Diagnosis was established on the basis of clinical history, skin tests and/or specific IgE assay. RESULTS: An IgE-mediated or non-IgE-mediated reaction was diagnosed in 786 cases (63%) and 467 cases (37%), respectively. The most common causes of anaphylaxis were neuromuscular blocking agents (NMBA) (N.=373, 47.4%), latex (N.=158, 20%), and antibiotics (N.=141, 18.1%). Succinylcholine (N.=226, 60.6%) was the most frequently incriminated NMBA, whereas the low frequency of reactions involving cis-atracurium was confirmed (N.=22, 5.9%) when market shares of each NMBA were taken into account. An increased number of reactions involving vital dyes was recorded (N.=34, 4.4%). CONCLUSION: These changes in the epidemiology of allergic reactions confirm the need for regular epidemiologic surveys of anaphylaxis in the perioperative period.