ABSTRACT
[Figure: see text].
Subject(s)
Blood Pressure/physiology , Endothelium, Vascular/physiopathology , Hypertension/physiopathology , Sleep Deprivation/physiopathology , Sleep/physiology , Acetylcholine/pharmacology , Aged , Ascorbic Acid/pharmacology , Blood Pressure/drug effects , Endothelium, Vascular/drug effects , Female , Forearm/blood supply , Humans , Male , Middle Aged , Regional Blood Flow/drug effects , Regional Blood Flow/physiology , Vasodilation/drug effects , Vasodilator Agents/pharmacologyABSTRACT
Two new isoquinoline alkaloids, named fumaranine (2) and fumarostrejdine (10), along with 18 known alkaloids were isolated from aerial parts of Fumaria officinalis. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound 2 was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3ß inhibitory activities. Parfumidine (8) and sinactine (15) exhibited potent POP inhibition activities (IC50 99±5 and 53±2â µM, resp.).
