[Changes in the hypophyseal-thyroid system under narcotic action in the parturients of a group at high risk of perinatal pathology]. / Izmenenie gipofizarno-tireoidnoi sistemy v usloviiakh narkoticheskogo deistviia u rozhenits gruppy vysokogo riska perinatal'noi patologii.

Eighty-seven parturients were examined to disclose the function of the thyroid during narcotic exposure in labor and in cesarean section in cases of high risk of giving birth to infants with perinatal abnormalities. Neurotropic agents were found to inhibit the fetal hypophyseo-thyroid system in cases with a history of intrauterine hypoxia, thus saving this system from exhaustion. Employment of various types of general anesthesia in cesarean section in this patient population provides an adequate maternal neurovegetative protection from surgical aggression.

[Contents of prostaglandins E2 and F2alpha and cAMP in the endometrium of women with habitual abortion during late pregnancy terms]. / Soderzhanie prostaglandinov E2 i F2 alfa i tsAMF v éndometrii zhenshchin, stradaiushchikh privychnym nevynashivaniem beremenosti pozdnikh srokov.

Measurements of prostaglandins E2 and F2 alpha in the endometrium of 35 women of a reproductive age, suffering from habitual abortions in late pregnancy terms, have shown elevation of these prostaglandin levels in the secretory phase as against the reference group and their normal values during the proliferative phase. It is possible, that disordered prostaglandin synthesis in the endometrium, manifesting in pregnancy, is one of the causes of habitual abortions. cAMP levels were somewhat decreased in the secretory phase in this patient population; this permits a hypothesis on disorders in the adenylate cyclase system.

[Endometrial steroid receptor levels in habitual abortion in advanced pregnancy]. / Soderzhanie steroidnykh retseptorov v éndometrii pri privychnom nevynashivanii beremennosti pozdnikh srokov.

Estrogen and progesterone reception was examined in the endometrial cytoplasmic and nuclear fraction from apparently healthy subjects and patients with habitual late incompetent pregnancy in the early proliferative and late secretory periods of a menstrual cycle. The reception of the two reproductive hormones in the nuclei and the binding of estrogens in the endometrial cytosol were demonstrated to be significantly higher in the female patients than in healthy subjects. The cytosol estrogen to progesterone reception ratio was increased in the patients in the secretory phase of a menstrual cycle than in normal females. There was a complete normalization of endometrial reproductive hormone receptor levels in the patients undergoing hyperbaric oxygenation.

[State of the sex hormone receptor in the endometrium of women with late habitual abortion]. / Sostoianie retseptornogo apparata polovykh gormonov v éndometrii zhenshchin pri privychnom nevynashivanii beremennosti pozdnikh srokov.

A study was made of estrogen and progesterone reception of the endometrial cytoplasmatic and nuclear fractions of healthy women and women suffering from late habitual abortion in the early proliferative and late secretory phases of the menstrual cycle. Reception of both sex hormones in the nuclei and estrogen binding in the endometrial cytosol of women with late habitual abortion was significantly higher than that in healthy women. The estrogen receptors/progesterone receptors ratio in the cytosol in the pathological endometrium at the secretory phase of the menstrual cycle was higher than in the normal one. Hyperbaric therapy given to such patients resulted in complete normalization of endometrial sex hormones reception.

[The postpartum period following preterm labor]. / Poslerodovyi period posle prezhdevremennykh rodov.

The course of the puerperium following the preterm labour is considered. The hormonal and lactation characteristics are analysed, and their characteristics are compared with those obtained following the term labour.

[Analysis of plasma levels of dehydroepiandrosterone and 17-hydroxyprogesterone in physiologic and pathologic pregnancy and labor]. / Dinamicheskoe opredelenie kontsentratsii degidroépiandrosterona i 17-oksiprogesterona v plazme krovi pri fiziologicheskom i patologicheskom techenii beremennosti i rodov.

Plasma levels of dehydroepiandrosterone (DEA) and 17-hydroxyprogesterone (17-HP) were studied in 43 pregnant females 11 with normal pregnancy and labor and 32 at high risk of obstetric complications (primary powerless labor, prematurity, postmaturity, rapid parturition). Hormonal investigation was performed in each particular female in the time-course of her pregnancy and labor as well as in the mixed blood plasma from the umbilical cord. Concentrations of hormones observed in the females with normal pregnancies and labors differed from those in the patients whose pregnancy was complicated as well as their labor. It has been concluded that the results of DEA and 17-HP variation assessment in the blood plasma are essential additional indicators of adrenal performance both in mother and fetus.

[Cortisol contents in maternal and umbilical artery blood during delivery of low birth weight fetuses]. / Soderzhanie kortizola v materinskoi i pupovinnoi krovi pri rodorazreshenii zhenshchin s malovesnymi plodami.

Cortisol was measured in 50 parturients with low birthweight (LBW) fetuses in the course of vaginal delivery (n-18) and cesarean section (n-32). Twenty normal parturients whose pregnancy and labor were uncomplicated were taken as controls. In the main group, low birthweights corresponded to gestational age in 30 parturients, and fetal growth retardation (FGR) was diagnosed in 20. In the course of vaginal delivery, maternal cortisol level increased significantly, the rise being higher in parturients with the FGR syndrome. In both groups, blood cortisol levels were higher in the umbilical artery as compared to umbilical vein; in FGR cases, umbilical-artery cortisol level approached the respective values in control newborns. Following cesarean section, LBW fetuses showed considerably lower umbilical cortisol levels. Separate examination of cortisol fractions has demonstrated that free cortisol goes up in the maternal blood both at vaginal and abdominal delivery. The effect of corticosteroids, used to prevent respiratory distress syndrome, on maternal adrenal activity and LBW fetuses has been evaluated.