ABSTRACT
The authors describe a case of advanced thoracic actinomycosis. A 44-year-old man with previous episodes of productive cough with purulent sputum, fever, chest pain and subcutaneous nodules on the left hemithorax was admitted with complaints of lumbar pain irradiating into left lower limb and presence of mass lesion on the left lumbar region. Imaging evaluations were obtained and the patient underwent left lower lobectomy. Histopathology, microscopic examination and anaerobic culture of the resected material diagnosed thoracic actinomycosis.
Subject(s)
Actinomycosis/diagnosis , Lung Diseases/diagnosis , Adult , Humans , Lung Diseases/microbiology , Male , Severity of Illness IndexABSTRACT
Hereditary hemorrhagic telangiectasia is an autosomal dominant disease in which arteriovenous communications are typically seen in the skin, mucosal surfaces, lungs, brain and gastrointestinal tract. This disease typically presents as epistaxis, gastrointestinal bleeding and arteriovenous malformations (in the brain and lungs). Although the epistaxis and gastrointestinal bleeding can result in anemia, patients diagnosed with hereditary hemorrhagic telangiectasia rarely present severe anemia. Herein, we report the case of a 49-year-old man with severe anemia and undiagnosed hereditary hemorrhagic telangiectasia.
Subject(s)
Anemia, Iron-Deficiency/etiology , Telangiectasia, Hereditary Hemorrhagic/complications , Anemia, Iron-Deficiency/diagnosis , Epistaxis/complications , Epistaxis/etiology , Gastrointestinal Hemorrhage/complications , Humans , Male , Middle Aged , Telangiectasia, Hereditary Hemorrhagic/diagnosisABSTRACT
The authors describe a case of advanced thoracic actinomycosis. A 44-year-old man with previous episodes of productive cough with purulent sputum, fever, chest pain and subcutaneous nodules on the left hemithorax was admitted with complaints of lumbar pain irradiating into left lower limb and presence of mass lesion on the left lumbar region. Imaging evaluations were obtained and the patient underwent left lower lobectomy. Histopathology, microscopic examination and anaerobic culture of the resected material diagnosed thoracic actinomycosis.
Subject(s)
Adult , Humans , Male , Actinomycosis/diagnosis , Lung Diseases/diagnosis , Lung Diseases/microbiology , Severity of Illness IndexABSTRACT
Telangiectasia hemorrágica hereditária é uma doença autossômica dominante na qual comunicações arteriovenosas afetam comumente pele, superfícies mucosas, pulmões, cérebro e trato gastrointestinal. As manifestações comuns desta doença são epistaxe, sangramento gastrointestinal, e malformações arteriovenosas cerebrais e pulmonares. Apesar de a epistaxe e o sangramento gastrointestinal poderem causar anemia, a telangiectasia hemorrágica hereditária raramente é diagnosticada com anemia grave. Neste artigo é relatado o caso de um homem de 49 anos de idade com telangiectasia hemorrágica hereditária não diagnosticada e anemia grave.
Hereditary hemorrhagic telangiectasia is an autosomal dominant disease in which arteriovenous communications are typically seen in the skin, mucosal surfaces, lungs, brain and gastrointestinal tract. This disease typically presents as epistaxis, gastrointestinal bleeding and arteriovenous malformations (in the brain and lungs). Although the epistaxis and gastrointestinal bleeding can result in anemia, patients diagnosed with hereditary hemorrhagic telangiectasia rarely present severe anemia. Herein, we report the case of a 49-year-old man with severe anemia and undiagnosed hereditary hemorrhagic telangiectasia.
Subject(s)
Humans , Male , Middle Aged , Anemia, Iron-Deficiency/etiology , Telangiectasia, Hereditary Hemorrhagic/complications , Anemia, Iron-Deficiency/diagnosis , Epistaxis/complications , Epistaxis/etiology , Gastrointestinal Hemorrhage/complications , Telangiectasia, Hereditary Hemorrhagic/diagnosisABSTRACT
É relatado um caso de abdome agudo causado por angiostrongilíase abdominal. Um paciente de 42 anos, previamente hígido, apresentou queixa de nove dias de dor abdominal, constipação, disúria, febre e uma massa palpável na fossa ilíaca direita. Uma laparotomia exploradora foi realizada. Após o tratamento cirúrgico o paciente apresentou graves complicações.
Subject(s)
Adult , Animals , Humans , Male , Abdomen, Acute/parasitology , Angiostrongylus cantonensis/immunology , Antibodies, Helminth/analysis , Strongylida Infections/complications , Abdomen, Acute/pathology , Abdomen, Acute/surgery , Enzyme-Linked Immunosorbent Assay , Laparotomy , Strongylida Infections/diagnosis , Strongylida Infections/pathology , Strongylida Infections/surgeryABSTRACT
A case of acute abdomen disease caused by abdominal angiostrongyliasis is reported. A 42-year-old otherwise healthy patient presented with a complaint of nine days of abdominal pain, constipation, disury, fever and right iliac fossa palpable mass. Exploratory laparotomy was performed. After surgical treatment the patient presented serious complications.
Subject(s)
Abdomen, Acute/parasitology , Angiostrongylus cantonensis/immunology , Antibodies, Helminth/analysis , Strongylida Infections/complications , Abdomen, Acute/pathology , Abdomen, Acute/surgery , Adult , Animals , Enzyme-Linked Immunosorbent Assay , Humans , Laparotomy , Male , Strongylida Infections/diagnosis , Strongylida Infections/pathology , Strongylida Infections/surgeryABSTRACT
Hyperammonemia is a common finding in children with methylmalonic acidemia, an inherited metabolic disease characterized by mental retardation, convulsions, and accumulation of methylmalonic acid (MMA). Although it has been suggested that MMA induces convulsions through succinate dehydrogenase (SDH) inhibition, very little is known about the contribution of hyperammonemia to the development of convulsions in these patients. In the present study we investigated the effects of ammonium ions on the convulsant action of MMA, MMA-induced inhibition of striatal succinate dehydrogenase, and the striatal content of thiobarbituric acid-reactive substances (TBARS). Adult rats were injected with ammonium acetate (1.5 mmol/kg, sc) or sodium acetate (1.5 mmol/kg, sc), followed 5 min later by buffered MMA (3 micromol/microl) or NaCl (4.5 micromol/microl) injected into the striatum. The animals were observed in an open field for the appearance of convulsive episodes. After 30 min of behavioral evaluation, the animals were sacrificed and had their striatal TBARS content measured. Ammonium acetate pretreatment caused no behavioral effects per se, but potentiated MMA-induced convulsions and increased basal TBARS content and MMA-induced TBARS production in the striatum. Ammonium chloride had no effect on basal succinate dehydrogenase activity and did not alter MMA-induced inhibition of SDH in vitro. These results suggest that ammonia potentiates MMA-induced behavioral effects through a mechanism that does not involve further succinate dehydrogenase inhibition, but may involve facilitation of MMA-induced oxidative damage and provide evidence that ammonia and MMA may have mutually additive toxicity.
Subject(s)
Ammonia/pharmacology , Methylmalonic Acid/toxicity , Seizures/physiopathology , Thiobarbituric Acid Reactive Substances/metabolism , Acetates/pharmacology , Ammonium Chloride/pharmacology , Animals , Behavior, Animal/drug effects , Corpus Striatum/chemistry , Corpus Striatum/drug effects , Corpus Striatum/metabolism , Drug Synergism , Enzyme Activation/drug effects , Enzyme Inhibitors/toxicity , Male , Rats , Rats, Wistar , Seizures/chemically induced , Succinate Dehydrogenase/antagonists & inhibitors , Succinate Dehydrogenase/metabolismABSTRACT
Sabe-se que gestações em mulheres diabéticas freqüentemente estäo relacionadas a complicações maternas e fetais. Entretanto, apesar de várias hipóteses, fortes evidências apontam a hiperglicemia materna, pré-concepcional e durante gestaçäo, como causa mais provável de tais complicações - entre elas as malformações congênitas, que säo seis a sete vezes mais comuns que na populaçäo geral. A normalizaçäo da glicemia pré-concepcional em mulheres diabéticas que planejam engravidar deve ser enfatizada como prioridade, e para um bom acompanhamento a hemoglobina glicosada é um bom indicador do controle glicêmico nos três meses prévios
