ABSTRACT
El citomegalovirus congénito es la etiología más frecuente de infección congénita viral y la principal causa de deficiencia neurosensorial adquirida intraútero. La infección derivada de una primoinfección materna tiene consecuencias más graves que las recurrentes en cuanto a la tasa de transmisión vertical, gravedad del cuadro clínico y secuelas a largo plazo. Se comunica una nueva observación de citomegalovirus congénito neonatal, en la que el diagnóstico se sospechó ante la presencia de un retraso de crecimiento intrauterino armónico, con clínica neurológica y alteraciones neurorradiológicas características, y se revisan los principales aspectos clínicos y epidemiológicos de la afección (AU)
Title: Neonatal congenital cytomegalovirus. Case report and review Summary. Congenital cytomegalovirus is the most frequent congenital viral infection etiology and the main cause of acquired intrauterine neurosensorial failure. The infection derived from a maternal primo-infection has more serious consequences than the recurrent ones as regards to the vertical transmission rate, severity of the clinical case and long-term after effects. A new observation of neonatal congenital cytomegalovirus is reported, whose diagnosis was suspected before the presence of harmonic intrauterine growth retardation, similar to the neurological clinic and characteristic neuroradiologic alterations. The main clinical and epidemiologic aspects of the infection are reviewed (AU)
Subject(s)
Humans , Male , Infant, Newborn , Cytomegalovirus Infections/congenital , Infectious Disease Transmission, Vertical , Cytomegalovirus/pathogenicity , Fetal Growth Retardation/etiologyABSTRACT
OBJECTIVE: To describe the clinical and radiological features, diagnosis, and treatment of an epidemic outbreak of tuberculosis in a daycare centre in Zaragoza. MATERIAL AND METHODS: The index case was a teaching assistant with a late diagnosis of bacilliferous tuberculosis. Mantoux testing was carried out in all children. In those with a positive Mantoux test, a chest X-ray was performed. Children with an abnormal chest X-ray underwent microbiological investigations. RESULTS: Among all the children in the daycare center, the Mantoux test was positive in 11 children. Chest X-ray was abnormal in 10 children. Of these, seven (70 %) were symptomatic. Chest X-ray showed dense opacification in nine children (90 %) and mediastinal lymph adenopathy in five (50 %). Three children (30 %) had lobar atelectasis requiring bronchoscopy and subsequent steroid therapy. Bacilloscopy was positive in only one child. Gastric juice culture was positive in seven children and the amplified Mycobacterium tuberculosis direct test was positive in a further seven. All microbiological investigations were negative in only one child. CONCLUSIONS: Establishing a definitive diagnosis of tuberculosis in children remains difficult and frequently relies on a constellation of clinical findings, radiology and epidemiology in children with a positive Mantoux test. The amplified Mycobacterium tuberculosis direct test has high sensitivity and provides fast results. Epidemic outbreaks continue to be frequent in Spain. Study of contacts shows high efficiency in controlling outbreaks.
Subject(s)
Disease Outbreaks , Tuberculosis, Pulmonary/epidemiology , Child Day Care Centers , Child, Preschool , Humans , Infant , Spain/epidemiology , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/drug therapyABSTRACT
Objetivo Describir la clínica, radiología, diagnóstico y tratamiento en los niños afectados por un brote de tuberculosis en una guardería de Zaragoza. Material y métodos El caso índice fue una cuidadora que fue diagnosticada tardíamente de tuberculosis activa. Se realizó Mantoux a todos los niños, a los positivos se hizo radiografía de tórax. En aquéllos con radiografía patológica se procedió al diagnóstico microbiológico. Resultados De todos los niños de la guardería, 11 presentaron un Mantoux positivo. La radiografía fue patológica en 10. De ellos, 7 (70 %) estaban sintomáticos. Las imágenes radiológicas mostraban en 9 (90 %) casos una condensación parenquimatosa y en 5 (50 %) una adenopatía parahiliar. Tres niños (30 %) presentaron atelectasia lobular y precisaron broncoscopia y administración posterior de corticoides. La baciloscopia fue positiva solamente en un niño, el cultivo en siete y la detección de muestra directa para el complejo tuberculosis en otros siete. Únicamente en un niño toda la investigación fue negativa. Conclusiones El diagnóstico de tuberculosis en la infancia es difícil, y a veces debe hacerse en base a unos criterios clínicos, radiológicos y epidemiológicos en niños con Mantoux positivo. Los test de detección de muestra directa para el complejo tuberculosis tienen una sensibilidad muy alta y proporcionan resultados muy rápidos. La aparición de brotes epidémicos continúa siendo un hecho frecuente en nuestro medio. El estudio de contactos en los mismos presenta un elevado rendimiento en el control de los brotes
Objective To describe the clinical and radiological features, diagnosis, and treatment of an epidemic outbreak of tuberculosis in a daycare centre in Zaragoza. Material and methods The index case was a teaching assistant with a late diagnosis of bacilliferous tuberculosis. Mantoux testing was carried out in all children. In those with a positive Mantoux test, a chest X-ray was performed. Children with an abnormal chest X-ray underwent microbiological investigations. Results Among all the children in the daycare center, the Mantoux test was positive in 11 children. Chest X-ray was abnormal in 10 children. Of these, seven (70 %) were symptomatic. Chest X-ray showed dense opacification in nine children (90 %) and mediastinal lymph adenopathy in five (50 %). Three children (30 %) had lobar atelectasis requiring bronchoscopy and subsequent steroid therapy. Bacilloscopy was positive in only one child. Gastric juice culture was positive in seven children and the amplified Mycobacterium tuberculosis direct test was positive in a further seven. All microbiological investigations were negative in only one child. Conclusions Establishing a definitive diagnosis of tuberculosis in children remains difficult and frequently relies on a constellation of clinical findings, radiology and epidemiology in children with a positive Mantoux test. The amplified Mycobacterium tuberculosis direct test has high sensitivity and provides fast results. Epidemic outbreaks continue to be frequent in Spain. Study of contacts shows high efficiency in controlling outbreaks
Subject(s)
Infant , Humans , Disease Outbreaks , Tuberculosis, Pulmonary/epidemiology , Child Day Care Centers , Spain/epidemiology , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/drug therapyABSTRACT
Nontuberculous or environmental mycobacterial disease in children has been increasingly recognized over the last decade. We present four patients who were diagnosed in the year 2000. The children were aged between 2 and 8 years. Three patients presented involvement of the cervical lymph nodes and one presented involvement of the inguinal nodes. Three of the children were treated with a combination of surgery and chemotherapy and one was treated with chemotherapy alone. We describe the clinical characteristics, laboratory findings, therapeutic management and complications of nontuberculous mycobacterial lymphadenitis in children.
Subject(s)
Mycobacterium Infections, Nontuberculous , Mycobacterium kansasii , Mycobacterium scrofulaceum , Age Factors , Anti-Bacterial Agents/therapeutic use , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Lymphadenitis/diagnosis , Lymphadenitis/etiology , Male , Mycobacterium Infections, Nontuberculous/diagnosis , Mycobacterium Infections, Nontuberculous/therapy , Mycobacterium avium-intracellulare Infection/diagnosis , Mycobacterium avium-intracellulare Infection/therapy , Time FactorsSubject(s)
Immunoglobulins, Intravenous/therapeutic use , Stevens-Johnson Syndrome/drug therapy , Anticonvulsants/adverse effects , Child , Epilepsy/drug therapy , Female , Follow-Up Studies , Humans , Immunoglobulins, Intravenous/administration & dosage , Lamotrigine , Stevens-Johnson Syndrome/diagnosis , Stevens-Johnson Syndrome/etiology , Time Factors , Triazines/adverse effectsABSTRACT
Las enfermedades ocasionadas por micobacterias no tuberculosas o ambientales han aumentado en la última década. Se presentan 4 casos diagnosticados durante el año 2000. Todos los niños tenían entre 2 y 8 años de edad. Tres casos presentaban afectación de los ganglios linfáticos cervicales y un caso de los inguinales. El tratamiento en 3 pacientes fue una combinación de cirugía y quimioterapia y un caso con quimioterapia solamente. En este trabajo se comentan las principales características clínicas, hallazgos de laboratorio, indicaciones terapéuticas y complicaciones de las linfoadenopatías producidas por micobacterias no tuberculosas (AU)
