ABSTRACT
Cuantificar la relación entre el asma y la hipertensión arterial inducida por el embarazo. Estudio de 200 casos con hipertensión inducida por el embarazo y 1222 controles. Análisis realizado por regresión logística múltiple. Hospital "Antonio María Pineda". Barquisimeto Lara 1998-2002. Hubo 131 embarazadas con asma documentada (9,21 por ciento y la hipertensión inducida por el embarazo fue más común en pacientes asmáticas (45/131; 34,35 por ciento) que en las no-asmáticas (155/1291; 12,01 por ciento. Luego del ajuste para posibles factores de confusión, se determinó una asociación significativa entre el asma y la hipertensión inducida por el embarazo (razón de probabilidades = 4,05; intervalo de 95 por ciento de confianza = 2,71 a 6,06 P < 0,0001). Este estudio confirma que el asma se relaciona con la hipertensión inducida por el embarazo pero el mecanismo de esta relación aún debe determinarse
Subject(s)
Female , Pregnancy , Humans , Asthma , Hypertension , Blood Pressure , Venezuela , Gynecology , ObstetricsABSTRACT
The herbicide paraquat is associated with a high mortality rate. It produces multiorgan damage through the induction of acute oxidative stress, by generation of reactive oxygen species that cause oxidative damage to biomolecules. In addition to general supportive measures, the management of paraquat poisoning includes gastric washing, forced diuresis, haemodialysis and the use of antioxidants, such as N-acetylcysteine. However, this drug is rather unavailable in Venezuela and S-carboxymethylcysteine has been used. We report 35 patients with mild to severe paraquat poisoning, which beside standard supportive treatment received 1500 mg S-carboxymethylcysteine, up to 2-3 w. The mortality rate was 22.86% (8 deaths/35 cases) and was related to the severity of paraquat poisoning (as assessed by urine dithionite tests). We conclude that S-carboxymethylcysteine is a reliable alternative in managing patients with paraquat poisoning.
Subject(s)
Carbocysteine/therapeutic use , Expectorants/therapeutic use , Herbicides/poisoning , Paraquat/poisoning , Adult , Carbocysteine/administration & dosage , Expectorants/administration & dosage , Female , Humans , Male , Medical Records , Poisoning/drug therapy , Poisoning/epidemiology , Poisoning/etiology , Poisoning/mortality , Poisoning/pathology , Retrospective Studies , Severity of Illness Index , Venezuela/epidemiologyABSTRACT
Since paraquat poisoning causes multiorgan damage through the generation of several redox products, the usual therapy includes antioxidative drugs, such as N-acetylcysteine. We investigated whether selected antioxidative drugs can improve survival from acute paraquat toxicity. Forty-eight male 2-3-mo-old Wistar rats were divided into 4 groups receiving paraquat dichloride in a single injection (11 mg/kg bw ip) I h before the administration of normal saline (control ip), S-carboxymethylcysteine (600 mg/kg bw po), propofol (100 mg/kg bw ip) or trimetazidine (10 mg/kg bw po). Animals were observed for 7 d. The median survival time in the control group was 3 d whereas it was 4 (p = 0.15), 4.5 (p < 0.05) or 5 (p < 0.05) d for the trimetazidine, S-carboxymethylcysteine or propofol-treated groups, respectively.
