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Anticancer Res ; 41(4): 1985-1995, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33813405

ABSTRACT

BACKGROUND/AIM: The aim of the study was to investigate boost volume definition, doses, and delivery techniques for rectal cancer dose intensification. PATIENTS AND METHODS: An online survey was made on 25 items (characteristics, simulation, imaging, volumes, doses, planning and treatment). RESULTS: Thirty-eight radiation oncologists joined the study. Twenty-one delivered long-course radiotherapy with dose intensification. Boost volume was delineated on diagnostic magnetic resonance imaging (MRI) in 18 centres (85.7%), and computed tomography (CT) and/or positron emission tomography-CT in 9 (42.8%); 16 centres (76.2%) performed co-registration with CT-simulation. Boost dose was delivered on gross tumor volume in 10 centres (47.6%) and on clinical target volume in 11 (52.4%). The most common total dose was 54-55 Gy (71.4%), with moderate hypofractionation (85.7%). Intensity-modulated radiotherapy (IMRT) was used in all centres, with simultaneous integrated boost in 17 (80.8%) and image-guidance in 18 (85.7%). CONCLUSION: A high quality of treatment using dose escalation can be inferred by widespread multidisciplinary discussion, MRI-based treatment volume delineation, and radiation delivery relying on IMRT with accurate image-guided radiation therapy protocols.


Subject(s)
Practice Patterns, Physicians'/statistics & numerical data , Radiotherapy Planning, Computer-Assisted , Radiotherapy, Intensity-Modulated , Rectal Neoplasms/radiotherapy , Tumor Burden/physiology , Female , Humans , Italy/epidemiology , Lymphatic Metastasis , Magnetic Resonance Imaging , Male , Neoplasm Staging , Positron Emission Tomography Computed Tomography , Positron-Emission Tomography , Radiotherapy Dosage , Radiotherapy Planning, Computer-Assisted/adverse effects , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy Planning, Computer-Assisted/statistics & numerical data , Radiotherapy, Image-Guided/adverse effects , Radiotherapy, Image-Guided/methods , Radiotherapy, Image-Guided/statistics & numerical data , Radiotherapy, Intensity-Modulated/adverse effects , Radiotherapy, Intensity-Modulated/methods , Radiotherapy, Intensity-Modulated/statistics & numerical data , Rectal Neoplasms/diagnosis , Rectal Neoplasms/mortality , Rectal Neoplasms/pathology , Surveys and Questionnaires , Survival Analysis , Tumor Burden/radiation effects
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