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Long-term protective immune response elicited by vaccination with an expression genomic library of Toxoplasma gondii.
Fachado, Alberto; Rodriguez, Alexandro; Molina, Judith; Silvério, Jaline C; Marino, Ana P M P; Pinto, Luzia M O; Angel, Sergio O; Infante, Juan F; Traub-Cseko, Yara; Amendoeira, Regina R; Lannes-Vieira, Joseli.
Infect Immun ; 71(9): 5407-11, 2003 Sep.
Article in English | MEDLINE | ID: mdl-12933894

ABSTRACT

Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine.


Subject(s)
Protozoan Vaccines/administration & dosage , Toxoplasma/immunology , Vaccines, DNA/pharmacology , Animals , Gene Expression , Genome, Protozoan , Genomic Library , Lymphocyte Activation , Male , Mice , Mice, Inbred BALB C , Protozoan Vaccines/genetics , Th1 Cells/immunology , Time Factors , Toxoplasma/genetics , Toxoplasmosis, Animal/immunology , Toxoplasmosis, Animal/prevention & control , Vaccination , Vaccines, DNA/genetics
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