ABSTRACT
The medical and social significance of acute cerebrovascular disturbances in the Russian Federation is considered. Purpose and tasks of early rehabilitation of patients with stroke are presented, its technology is described. Non-drug and pharmacological methods of rehabilitation are presented. The efficacy of neuromidin in the early rehabilitation of patients with a stroke is shown.
Subject(s)
Aminoquinolines/therapeutic use , Cholinesterase Inhibitors/therapeutic use , Stroke Rehabilitation , Stroke/epidemiology , Combined Modality Therapy , Humans , Russia/epidemiology , Stroke/physiopathologyABSTRACT
Efficacy of omaron (a combination of piracetam 400 mg and cinnarizin 25 mg) has been studied 3 months after stroke in 90 post-stroke patients. Forty-five patients receiving the basic therapy (antihypertensive and antithrombotic drugs, statins) have been included in the control group and 45 patients of the main group received in addition omaron (1 pill 3 times daily during 2 months). Intensity of neurologic disturbances, degree of disability, cognitive functions assessed by neuropsychological tests (the Mini-Mental State Examination, the Frontal Assessment battery, the Five words test, the Clock drawing test, the Schulte test) and emotional state (the Centre for Epidemiologic Studies Depression scale, the Spilberger scale) have been measured. During the period of the study, none of the patients had stroke or myocardial infarction. The improvement of indices of neurological status, decrease of disability degree and normalization of arterial pressure were found in both groups after 2 months of treatment. The significant improvement (p<0,05) of performance on tests for neurocognitive functions and parameters of emotional state was noted in patients treated with omaron compared to those of the control group. The good tolerability of omaron, absence of serious side-effect in combination with other drugs used for prevention of secondary stroke were reported.
Subject(s)
Cinnarizine/therapeutic use , Cognition Disorders/drug therapy , Cognition/physiology , Piracetam/therapeutic use , Stroke/complications , Administration, Oral , Aged , Cinnarizine/administration & dosage , Cognition/drug effects , Cognition Disorders/etiology , Cognition Disorders/physiopathology , Dose-Response Relationship, Drug , Drug Combinations , Female , Follow-Up Studies , Histamine H1 Antagonists/administration & dosage , Histamine H1 Antagonists/therapeutic use , Humans , Male , Middle Aged , Neuroprotective Agents/administration & dosage , Neuroprotective Agents/therapeutic use , Piracetam/administration & dosage , Treatment OutcomeABSTRACT
Cortexin was used in prophylaxis of stroke among patients with cerebrovascular diseases. A course of cortexin therapy proved highly effective in the treatment of disorders of brain functions.
