ABSTRACT
New biologic and small molecule targeted agents have expanded the armamentarium of Spondyloarthritides (SpA), allowing more therapeutic options for patients who do not respond to therapy. The implementation of the treat-to-target (T2T) strategy with close monitoring and frequent treatment adaptations targeting disease remission has been proposed as the means to prevent radiographic progression and long-term adverse outcomes. In this project we will employ the "University of Crete Rheumatology Clinic Registry" to prospectively study in real-world practice musculoskeletal and extraarticular disease activity, patient function, comorbidities, sociodemographics, imaging, compliance to therapy and other lifestyle factors in axial and peripheral SpA patients. The predictive value of these variables in long-term (2years) outcomes will be evaluated. We will also assess the implementation of the T2T approach as well as its impact on long-term patients' outcomes (quality of life, productivity, adverse events). The successful completion of this study could pave the way for improved and personalized therapy in patients with SpA.
ABSTRACT
Pasteurella multocida is a rare cause of bacterial meningitis, more frequently affecting humans at the extremes of age. We report a case of meningitis and bacteremia caused by P. multocida in a 67-year-old diabetic woman who was living with 10 cats. She didn't have any animal bites or scratches, but she reported kissing the pets in the mouth. The outcome was favorable following antimicrobial treatment. Although rarely encountered, P. multocida should be considered as a possible cause of meningitis, particularly when Gram-negative coccobacilli are revealed in the cerebrospinal fluid and a history of recent animal contact is present.
