ABSTRACT
No disponible
Subject(s)
Humans , Tissue Donors , Social Networking , Mass Media , Tissue and Organ Procurement/organization & administration , Transplants , Spain , Public OpinionABSTRACT
La interpretación de los resultados estadísticos es un elemento crucial para la comprensión de los avances en las ciencias médicas. Las herramientas que nos ofrece la estadística nos permiten transformar la incertidumbre y aparente caos de la naturaleza en parámetros medibles y aplicables a nuestra práctica clínica. La importancia de entender el significado y alcance real de estos instrumentos es fundamental para el investigador, para los financiadores de las investigaciones y para los profesionales que precisan de una actualización permanente basada en buena evidencia y ayudas a la toma de decisiones. Se repasan diversos aspectos de los diseños, resultados y análisis estadísticos, intentando facilitar su entendimiento desde lo más elemental a aquello que es más común pero no por ello mejor comprendido y aportar una mirada constructiva y realista, sin ser exhaustiva
The appropriate interpretation of the statistical results is crucial to understand the advances in medical science. The statistical tools allow us to transform the uncertainty and apparent chaos in nature to measurable parameters which are applicable to our clinical practice. The importance of understanding the meaning and actual extent of these instruments is essential for researchers, the funders of research and for professionals who require a permanent update based on good evidence and supports to decision making. Various aspects of the designs, results and statistical analysis are reviewed, trying to facilitate his comprehension from the basics to what is most common but no better understood, and bringing a constructive, non-exhaustive but realistic look
Subject(s)
Humans , Data Interpretation, Statistical , Health SciencesABSTRACT
The appropriate interpretation of the statistical results is crucial to understand the advances in medical science. The statistical tools allow us to transform the uncertainty and apparent chaos in nature to measurable parameters which are applicable to our clinical practice. The importance of understanding the meaning and actual extent of these instruments is essential for researchers, the funders of research and for professionals who require a permanent update based on good evidence and supports to decision making. Various aspects of the designs, results and statistical analysis are reviewed, trying to facilitate his comprehension from the basics to what is most common but no better understood, and bringing a constructive, non-exhaustive but realistic look.
Subject(s)
Data Interpretation, StatisticalABSTRACT
Los quistes pericárdicos son raros, y la mayoría de ellos son de origen congénito. Normalmente se localizan en los ángulos cardiofrénicos, principamente en el lado derecho. A pesar de que la forma de presentación clínica más frecuente es asintomático y el pronóstico es benigno, se han descrito importantes complicaciones. Por ello clásicamente se ha tendido a una actitud terapeútica agresiva como aspiración percutánea o resección quirúrgica mediante toracotomía o toracoscopia. El caso que describimos es interesante por tratarse de un quiste pericárdico de localización inusual, paramediastínico superior izquierda, y de origen fue postraumático, no congénito. El diagnóstico se realizó por las pruebas de imagen, y tomamos una actitud terapéutica conservadora debido a la buena evolución. Proponemos por ello la opción de tratamiento conservador como actitud válida y razonable en la ausencia de complicaciones o síntomas en su evolución
Pericardial cyst are rare, most of them congenital in origin. They usually are located in the cardiophrenic angles, mainly on the right side. Although the most frequent clinical presentation is asyntomatic, and the prognosis is benign, important complications had been described. For this reason we used to take agressive therapeutic interventions like percutaneous aspiracion or surgical reseccion by thoracotomia or thoracoscophy. The case we report is interesting because it was an atipically located left upper paramediastinal cyst, and not congenital in origin but postraumatic. The diagnosis was made by imaging techniques and we accomplished conservative alternative because of the favourable evolution. We think that it should be a good option in case of asyntomatic and no complicated cases
Subject(s)
Male , Adolescent , Humans , Mediastinal Cyst/diagnosis , Mediastinal Cyst/etiology , Thoracic Injuries/complications , MotorcyclesABSTRACT
El minoxidil es un potente vasodilatador oral que era frecuentemente utilizado en hipertensión arterial refractaria a tratamiento con otros fármacos, cuya relación con la aparición de derrame pericárdico se conoce prácticamente desde el comienzo de su uso clínico. Describimos un caso de derrame pericárdico grave asociado a la toma de minoxidil durante más de 20 años que responde favorablemente a la retirada del fármaco a pesar de tan larga evolución. La incidencia descrita de derrame pericárdico por minoxidil se encuentra entre un 0 %-26 % y, a pesar de la posible evolución hacia taponamiento cardíaco en raros casos, el manejo conservador con la retirada del fármaco es la primera opción, que en nuestra opinión debe serlo incluso cuando el derrame sea grave y de muy larga evolución
Minoxidil is a potent oral vasodilator that was frequently used in HBP refractory to treatment with other drugs, whose relationship with the appearance of pericardial effusion has practically been known since the onset of its clinical use. We describe a case of severe pericardial effusion, associated to taking minoxidil for more than 20 years that favorably responds to withdrawal of the drug in spite of such a long course. The incidence described of pericardial effusion due to minoxidil is between 0 %-26 %. In spite of the possible evolution towards cardiac tamponade in rare cases, the conservative management with drug withdrawal is the first option, which, in our opinion, should even be so when the effusion is severe and of long duration
Subject(s)
Humans , Pericardial Effusion/chemically induced , Minoxidil/adverse effects , Hypertension/complications , Hypertension/drug therapyABSTRACT
El minoxidil es un potente vasodilatador oral que era frecuentemente utilizado en hipertensión arterial refractaria a tratamiento con otros fármacos, cuya relación con la aparición de derrame pericárdico se conoce prácticamente desde el comienzo de su uso clínico. Describimos un caso de derrame pericárdico grave asociado a la toma de minoxidil durante más de 20 años que responde favorablemente a la retirada del fármaco a pesar de tan larga evolución. La incidencia descrita de derrame pericárdico por minoxidil se encuentra entre un 0 %-26 % y, a pesar de la posible evolución hacia taponamiento cardíaco en raros casos, el manejo conservador con la retirada del fármaco es la primera opción, que en nuestra opinión debe serlo incluso cuando el derrame sea grave y de muy larga evolución
Minoxidil is a potent oral vasodilator that was frequently used in HBP refractory to treatment with other drugs, whose relationship with the appearance of pericardial effusion has practically been known since the onset of its clinical use. We describe a case of severe pericardial effusion, associated to taking minoxidil for more than 20 years that favorably responds to withdrawal of the drug in spite of such a long course. The incidence described of pericardial effusion due to minoxidil is between 0 %-26 %. In spite of the possible evolution towards cardiac tamponade in rare cases, the conservative management with drug withdrawal is the first option, which, in our opinion, should even be so when the effusion is severe and of long durationMinoxidil is a potent oral vasodilator that was frequently used in HBP refractory to treatment with other drugs, whose relationship with the appearance of pericardial effusion has practically been known since the onset of its clinical use. We describe a case of severe pericardial effusion, associated to taking minoxidil for more than 20 years that favorably responds to withdrawal of the drug in spite of such a long course. The incidence described of pericardial effusion due to minoxidil is between 0 %-26 %. In spite of the possible evolution towards cardiac tamponade in rare cases, the conservative management with drug withdrawal is the first option, which, in our opinion, should even be so when the effusion is severe and of long duration
Subject(s)
Humans , Minoxidil/adverse effects , Pericardial Effusion/chemically induced , Hypertension/drug therapy , Cardiac Tamponade/physiopathology , Antihypertensive Agents/therapeutic useABSTRACT
Pericardial cyst are rare, most of them congenital in origin. They usually are located in the cardiophrenic angles, mainly on the right side. Although the most frequent clinical presentation is asymptomatic, and the prognosis is benign, important complications had been described. For this reason we used to take aggressive therapeutic interventions like percutaneous aspiration or surgical resection by thoracotomia or thoracoscopy. The case we report is interesting because it was an atypically located left upper paramediastinal cyst, and not congenital in origin but posttraumatic. The diagnosis was made by imaging techniques and we accomplished conservative alternative because of the favourable evolution. We think that it should be a good option in case of asymptomatic and no complicated cases.
