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2.
Case Rep Obstet Gynecol ; 2019: 5231219, 2019.
Article in English | MEDLINE | ID: mdl-32089915

ABSTRACT

UTROSCTs (Uterine Tumors Resembling Ovarian Sex Cord Tumors) are rare neoplasms of unknown etiology usually occurring in middle-aged women. Less than 100 cases of UTROSCT have been reported so far. Although the typical behavior of UTROSCT is benign, metastatic and recurrent cases can occur. Here we describe an extremely rare case of vaginal vault recurrence of UTROSCT occurring 5 years after total hysterectomy with bilateral salpingo-oophorectomy. Though rare, UTROSCT should always be taken into account in the differential diagnosis of uterine masses initially considered leiomyomas.

3.
Pediatr Hematol Oncol ; 35(3): 167-176, 2018 Apr.
Article in English | MEDLINE | ID: mdl-30230941

ABSTRACT

AIM: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for childhood sarcoma. METHODS: A cross-sectional single center study was performed. Outcomes included estimating glomerular filtration rate (eGFR), albuminuria, glycosuria, serum phosphate and magnesium, tubular reabsorption phosphate (TRP), chronic kidney disease (CKD) according to the "Kidney Disease: Improving Global Outcomes" (KDIGO) guidelines and blood pressure (BP). RESULTS: Out of 87 > 5-year sarcoma survivors, 30 adults (10F/20M, median age at diagnosis 9 years, median age at investigation 26 years, median follow-up 16 years, mean 19 years) were identified. Renal impairment was detected in four cases (13.3%); three of these fulfilled the criteria for CKD. Among the adult survivors, a subgroup of 15 cases (50%) had received ifosfamide without confounding factors such as a diagnosis of genito-urinary rhabdomyosarcoma or administration of other potentially nephrotoxic chemotherapy (platinum-based drugs or methotrexate); no renal dysfunction was detected in this subgroup. In the whole cohort of sarcoma survivors, hypertension was diagnosed in four cases (13.3%); BP was significantly correlated with body mass index [p .014]. CONCLUSION: In our series of adult survivors treated for a diagnosis of sarcoma in their childhood, the prevalence of CKD was 10%. We found survivors treated with ifosfamide as the only nephrotoxic agent did not present glomerular or tubular toxicity at long term follow-up, but further studies including a larger number of cases are required to confirm it.


Subject(s)
Hypertension/epidemiology , Ifosfamide/adverse effects , Kidney Diseases/epidemiology , Sarcoma/drug therapy , Survivors/statistics & numerical data , Adolescent , Adult , Antineoplastic Agents, Alkylating/adverse effects , Body Mass Index , Child , Child, Preschool , Cross-Sectional Studies , Female , Glomerular Filtration Rate , Humans , Hypertension/chemically induced , Hypertension/pathology , Incidence , Infant , Italy/epidemiology , Kidney Diseases/chemically induced , Kidney Diseases/pathology , Kidney Function Tests , Male , Middle Aged , Young Adult
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