Endoscopic third ventriculostomy in children with chronic communicating congenital hydrocephalus: a single-center cohort retrospective analysis.

OBJECTIVE: The aim of this study was to analyze the role of endoscopic third ventriculostomy (ETV) in the treatment of pediatric chronic communicating congenital hydrocephalus (CCCH). MATERIAL AND METHODS: This retrospective study comprised a series of 11 children with CCCH treated with ETV. Data were recorded on gender, history, presenting symptoms, age at surgery, complications during surgery, clinical evolution, ETV survival, and follow-up period. Radiological variables including ventricular and cephalic diameters were also recorded to determine a series of ventricular indexes in magnetic resonance imaging (MRI) before and after the ETV procedure. The procedure was considered to be successful when there was clinical stability or improvement accompanied by a reduction in the radiological indexes in the postoperative control images, such that there was no need to place an extrathecal cerebrospinal fluid shunt. RESULTS: Over a mean follow-up period of 35.8 months (range: 6-108 months) from the ETV procedure, three patients required shunt placement; one of these was due to early failure in an 8-month old girl, the only patient younger than 12 months in our series. The radiological indexes were reduced in all patients except for one of the cases of ETV failure. The mean ETV survival among the successful cases was 32.1 months (range: 6-108 months), whilst that of the failed cases was 16 months (range: 6-108 months). CONCLUSION: Although studies with larger sample sizes are needed, ETV appears to be a promising option for the treatment of this type of patient with CCCH.

Cervical myelomeningocele with CSF leakage: a case-based review.

BACKGROUND: The cystic spinal dysraphism of the cervical and upper thoracic region (CDCT) accounts for only 3.9 to 8% of spina bifida cystica lesions. The presence of external cerebrospinal fluid (CSF) leakage is infrequent and very few authors have reported about surgical complications. CASE REPORT: We present the case of a new born diagnosed of CDCT C1-C3 with a stalk of fibrovascular tissue, CSF leakage, hydrocephalus, and type Chiari II malformation, discuss about the chosen surgical technique and the associated complications, and make a review of the literature focusing on the main aspects of CDCT. CONCLUSIONS: The CDCT with a stalk of neuroglial and/or fibrovascular tissue originates from the dorsal surface of the spinal cord and penetrates into a cervical cystic sac. The presence of CSF leakage, hydrocephalus, and/or type Chiari II malformation can influence to decide the most appropriate surgical technique.

Suprasellar ganglioglioma presenting as a middle cerebral artery infarction.

BACKGROUND: Gangliogliomas are a relatively rare neoplasm with a major incidence in the pediatric population. As the temporal lobes are the most common site, patients usually present with seizures. CASE REPORT: We report the case of a 9-year-old child with an extensive suprasellar ganglioglioma presenting with a cerebral infarction due to direct compression of the medium cerebral artery. CONCLUSIONS: Suprasellar lesions can compress adjacent vascular structures, so an accurate diagnosis is necessary for an early treatment.

Increased levels of tumour necrosis factor alpha (TNFα) but not transforming growth factor-beta 1 (TGFß1) are associated with the severity of congenital hydrocephalus in the hyh mouse.

AIMS: Here, we tested the hypothesis that glial responses via the production of cytokines such as transforming growth factor-beta 1 (TGFß1) and tumour necrosis factor alpha (TNFα), which play important roles in neurodegenerative diseases, are correlated with the severity of congenital hydrocephalus in the hyh mouse model. We also searched for evidence of this association in human cases of primary hydrocephalus. METHODS: Hyh mice, which exhibit either severe or compensated long-lasting forms of hydrocephalus, were examined and compared with wild-type mice. TGFß1, TNFα and TNFαR1 mRNA levels were quantified using real-time PCR. TNFα and TNFαR1 were immunolocalized in the brain tissues of hyh mice and four hydrocephalic human foetuses relative to astroglial and microglial reactions. RESULTS: The TGFß1 mRNA levels were not significantly different between hyh mice exhibiting severe or compensated hydrocephalus and normal mice. In contrast, severely hydrocephalic mice exhibited four- and two-fold increases in the mean levels of TNFα and TNFαR1, respectively, compared with normal mice. In the hyh mouse, TNFα and TNFαR1 immunoreactivity was preferentially detected in astrocytes that form a particular periventricular reaction characteristic of hydrocephalus. However, these proteins were rarely detected in microglia, which did not appear to be activated. TNFα immunoreactivity was also detected in the glial reaction in the small group of human foetuses exhibiting hydrocephalus that were examined. CONCLUSIONS: In the hyh mouse model of congenital hydrocephalus, TNFα and TNFαR1 appear to be associated with the severity of the disease, probably mediating the astrocyte reaction, neurodegenerative processes and ischaemia.

[Liposarcoma of the perirenal cell]. / Liposarcoma de la celda perirrenal.

OBJECTIVES: To show the imaging tests characteristics and differential diagnosis of masses located within the retroperitoneal perirenal area. METHODS: Diagnostic imaging tests (KUB x-ray, ultrasound, helical CT scan with IV contrast) and follow-up in one case of perirenal cell liposarcoma. RESULTS: The study of the surgical specimen after renal tumorectomy in a patient with a solitary kidney resulted in the present diagnosis. CONCLUSIONS: Liposarcoma is a malignant neoplasia derived from fatty tissue. Approximately 13% are located in the retroperitoneal area, and less than 1/3 arise from perinephric fat. We report one case of liposarcoma located in the perirenal cell as an incidental finding during contralateral psoas muscle abscess follow-up in a patient with a solitary kidney after surgery for xanthogranulomatous pyelonephritis. Successive controls during the last year allowed us to evaluate the evolution of this lesion's.

Liposarcoma de la celda perirrenal / Perirenal cell liposarcoma

OBJETIVO: Mostrar las características de imagen y el diagnóstico diferencial de las masas localizadas en el área retroperitoneal perirrenal. MÉTODO: Estudio por imagen (RX abdomen, Ecografía, TC helicoidal con contraste intravenoso) diagnóstico y de seguimiento de un caso de liposarcoma de la celda perirrenal. RESULTADO: El estudio de la pieza quirúrgica de la tumerectomía renal en una paciente monorrena dio como resultado el caso presentado. CONCLUSIONES: El liposarcoma es una neoplasia maligna derivada del tejido adiposo; aproximadamente un 13 por ciento se localiza en retroperitoneo, y menos de un tercio se origina en la grasa perinéfrica, constituyendo el liposarcoma perirrenal. Presentamos un caso de liposarcoma localizado en la celda perirrenal como hallazgo incidental del seguimiento de un abceso del psoas contralateral en una paciente monorrena tras cirugía por pielonefritis xantogranulomatosa. Los controles en el último año han permitido valorar la evolución de la imagen de esta lesión (AU)