ABSTRACT
AIM: Accurate diagnosis of complicated appendicitis is of importance to ensure that patients receive early and effective treatment, minimizing the risk of postoperative complications to promote successful recovery. Biochemical markers are a promising tool to identify complicated appendicitis. We aimed to evaluate the potential role of novel parameters related with neutrophil activation, known as "Extended Inflammation Parameters" (EIP), included in blood cell count reported by Sysmex XN-Series analyzers, compared to other canonical biomarkers in identifying complicated appendicitis. METHOD: Prospective observational study including patients with confirmed diagnosis of acute appendicitis. C-reactive protein (CRP), procalcitonin, cell blood count, including white blood cell (WBC), absolute neutrophil (ANC) and immature granulocyte (IG) count and EIP (neutrophil reactivity [NEUT-RI] and granularity intensity [NEUT-GI]) were analyzed before surgery. Their accuracy to diagnose complicated appendicitis was tested in an ROC curve analysis. RESULTS: Our population study included 119 patients, and appendicitis was complicated in 58 (48.7%). NLR, CRP and procalcitonin levels, ANC and IG count and NEUT-RI and NEUT-GI were higher in patients with complicated appendicitis. Regarding accuracy for complicated appendicitis, CRP was the biomarker with the highest performance (ROC AUC: 0.829), with an optimal cutoff of 73.1 mg/L (sensitivity: 63.8%, specificity: 88.5%). NEUT-RI and NEUT-GI achieved both significant but poor accuracy, with ROC AUC of 0.606 and 0.637, respectively. CONCLUSIONS: Novel laboratory tests reported by Sysmex XN-Series analyzers have poor accuracy for identifying complicated appendicitis. In this study, CRP was the biomarker with the highest performance and may be useful as predictor of the severity of acute appendicitis.
Subject(s)
Appendicitis , Biomarkers , C-Reactive Protein , Neutrophil Activation , Procalcitonin , Appendicitis/blood , Appendicitis/diagnosis , Appendicitis/surgery , Humans , Prospective Studies , Female , Male , Adult , C-Reactive Protein/analysis , Middle Aged , Biomarkers/blood , Procalcitonin/blood , Acute Disease , Leukocyte Count/methods , Leukocyte Count/instrumentation , Hematologic Tests/methods , Hematologic Tests/instrumentation , ROC Curve , Aged , Neutrophils , Inflammation/bloodSubject(s)
Appendicitis , Hematology , Acute Disease , Appendicitis/diagnosis , Automation, Laboratory , Blood Cell Count , Humans , Neutrophil ActivationABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Abdomen, Acute/etiology , Diverticulum/complications , Jejunal Diseases/complications , Abdomen, Acute/diagnostic imaging , Diverticulum/diagnostic imaging , Intestinal Perforation/complications , Intestinal Perforation/diagnostic imaging , Jejunal Diseases/diagnostic imaging , Tomography, X-Ray ComputedSubject(s)
Abdomen, Acute/etiology , Diverticulum/complications , Jejunal Diseases/complications , Abdomen, Acute/diagnostic imaging , Aged , Diverticulum/diagnostic imaging , Female , Humans , Intestinal Perforation/complications , Intestinal Perforation/diagnostic imaging , Jejunal Diseases/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Resumen El linfoma difuso de células grandes B (LDCGB) es el tipo de linfoma más frecuente, constituyendo un 35% de todos los casos de linfoma no Hodgkin (LNH). El linfoma no-Hodgkin primario de bazo (LNHPB) presenta una incidencia menor al 1% de todos los linfomas. Los linfomas doble hit están relacionados con el reordenamiento del gen MYC asociado a otra alteración molecular. Tienden a presentarse en varones de edad avanzada y se caracterizan principalmente por su comportamiento agresivo.
Abstract Diffuse Large-cell Lymphoma B (DLCLB) is the most common type of lymphoma, constituting 35% of all cases of Non-Hodgkin's Lymphoma (NHL). Primary Splenic Non-Hodgkin Lymphoma (PS-NHL) has an incidence of less than 1% of all lymphomas. The ''double hit'' lymphomas are related to the rearrangement of the MYC gene associated with another molecular alteration. They used to appear in older men and are mainly characterised by their aggressive behaviour.
Subject(s)
Humans , Male , Aged , Aged, 80 and over , Spleen , Genes, myc , Aggression , Prognosis , Lymphoma, Non-Hodgkin , Lymphoma, Large B-Cell, DiffuseABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Glucagonoma/diagnostic imaging , Necrolytic Migratory Erythema/physiopathology , Liver Neoplasms/secondary , Glucagonoma/drug therapy , Glucagonoma/surgery , Psoriasis/physiopathology , Tomography, Spiral Computed/methods , Pancreatectomy/methodsABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Breast Neoplasms/pathology , Carcinosarcoma/pathology , Mastectomy , Neoplasm Recurrence, Local/prevention & control , Neoplasm Metastasis/prevention & control , Lymphatic Metastasis/prevention & controlSubject(s)
Diagnostic Errors , Glucagonoma/complications , Pancreatic Neoplasms/complications , Psoriasis/diagnosis , Skin Diseases/etiology , Biopsy , Diagnosis, Differential , Glucagonoma/diagnostic imaging , Glucagonoma/secondary , Glucagonoma/surgery , Humans , Liver Neoplasms/secondary , Lymphatic Metastasis , Male , Middle Aged , Pancreatic Neoplasms/diagnostic imaging , Pancreatic Neoplasms/surgery , Skin Diseases/pathology , Tomography, X-Ray ComputedABSTRACT
No disponible
