Experimental Characterisation of Lime-Based Textile-Reinforced Mortar Systems Made of Either Jute or Flax Fabrics.

Existing buildings are often in need of strengthening interventions, and several technical solutions have been recently developed for this purpose. Among them, the use of textile-reinforced mortar (TRM) composites has gained consensus as a technically viable and economically convenient option. Moreover, TRM has the potential to be employed as a reversible and sustainable strengthening technique for masonry buildings. In this context, the present paper aims to investigate the mechanical properties of TRM systems consisting of sustainable phases, such as lime-based matrices and natural fabrics produced by waiving fibers obtained from plants, such as Jute or Flax. This class composite system can be referred to as natural TRM and is denoted by the acronym NTRM. The present study moves from the geometric and mechanical characterisation of fibres and fabrics and, after having also investigated the properties of the mortar, it reports the results of tensile tests carried out on specimens of the NTRM systems under consideration, with the main aim of providing the empirical bases of the relationships between the geometric and physical properties of the constituents and the resulting mechanical response of the composite system. The obtained results show that the considered Flax-TRM system has an apparent composite behavior, as its response to tension is clearly characterised by the well-known three stages corresponding to the elastic response, the formation of cracks, and the reinforcement response up to rupture. Conversely, the Jute-TRM system needs to be further improved in terms of balance between the properties of the matrix and the internal reinforcement. Further studies will be devoted to this specific aspect and, more generally, to investigating the relationships between constituents' properties and the NTRM behavior.

Theoretical Modelling of the Degradation Processes Induced by Freeze-Thaw Cycles on Bond-Slip Laws of Fibres in High-Performance Fibre-Reinforced Concrete.

High-performance fibre-reinforced concrete (HPFRC) is a composite material in which the advantages of fibre-reinforced concrete (FRC) are combined with those of a high-performance concrete (HPC), which mitigates the weaknesses of conventional concrete and improves its overall performance. With the aim to reduce the long-term maintenance costs of structures, such as heavily loaded bridges, HPFRC is highly recommended due to its major durability performance. Specifically, its good antifreezing property makes it suitable for application in cold regions where cyclic freeze-thaw conditions cause the concrete to degrade. In this paper, a numerical simulation of the degradation processes induced by freeze-thaw cycles on bond-slip laws in HPFRC beam specimens has been developed so as to assess their effect on the flexural response of specimens as the fibres' volume percentage changes. Their cracking strength, postcracking strength, and toughness were predicted, with the present model being able to predict the cracking strength, postcracking strength and toughness of the HPFRC beam element under bending load conditions. Its accuracy was confirmed by comparing the model predictions with experimental results.

Low-Cycle Fatigue of FRP Strips Glued to a Quasi-Brittle Material.

This paper aims at further advancing the knowledge about the cyclic behavior of FRP strips glued to quasi-brittle materials, such as concrete. The results presented herein derive from a numerical model based on concepts of based on fracture mechanics and already presented and validated by the authors in previous works. Particularly, it assumes that fracture processes leading to debonding develop in pure mode II, as is widely accepted in the literature. Starting from this assumption (and having clear both its advantages acnd shortcomings), the results of a parametric analysis are presented with the aim of investigating the role of both the mechanical properties of the interface bond-slip law and a relevant geometric quantity such as the bond length. The obtained results show the influence of the interface bond-slip law and FRP bond length on the resulting cyclic response of the FRP-to-concrete joint, the latter characterized in terms of S-N curves generally adopted in the theory of fatigue. Far from deriving a fully defined correlation among those parameters, the results indicate general trends that can be helpful to drive further investigation, both experimental and numerical in nature.

Mechanical Response and Analysis of Cracking Process in Hybrid TRM Composites with Flax Textile and Curauá Fibres.

In recent years, the use of plant fibres in Textile-Reinforced Mortar (TRM) composites emerged as a valuable solution to increase their sustainability. Several studies carried out to mechanically characterize the so-called Natural TRMs, although showing promising results, also emphasised some drawbacks due to a severe deformability of the system and to durability issues. This study aims at improving the mechanical behaviour of Natural TRMs including impregnated flax textile (Flax TRMs) by the addition of short curauá fibres within the matrix. Flax TRM specimens were tested in tension to assess the influence of the fibre-reinforced mortar on the composite response. The crack pattern developed during the test was investigated via Digital Image Correlation analysis and by means of an analytical simplified model proposed by the authors. The addition of curauá fibres resulted in a denser crack pattern and in a significant decrease of the mean crack width (around 20%). The overall tensile response of Flax TRMs including curauá fibres resulted closer to the ideal three-linear behaviour of strain-hardening TRM composites with respect to the conventional Flax TRMs by also presenting an increase of dissipated energy of around 45%. This study paves the way for further analysis aimed at enhancing the mechanical performance of Natural TRMs adopting sustainable improvement techniques.

Influence of Wetting and Drying Cycles on Physical and Mechanical Behavior of Recycled Aggregate Concrete.

Recently, concerns have been rising about the impact of increasing the depletion of natural resources and the relevant generation of construction and demolition waste, on the environment and economy. Therefore, several efforts have been made to promote sustainable efficiency in the construction industry and the use of recycled aggregates derived from concrete debris for new concrete mixtures (leading to so-called recycled aggregate concrete, RAC) is one of the most promising solutions. Unfortunately, there are still gaps in knowledge regarding the durability performances of RAC. In this study, we investigate durability of structural RAC subjected to wet-dry cycles. We analyze the results of an experimental campaign aimed at evaluating the degradation process induced by wetting and drying cycles on the key physical and mechanical properties of normal- and high-strength concrete, produced with coarse recycled concrete aggregates (RCAs) of different sizes and origins. On the basis of the results we propose a degradation law for wetting and drying cycles, which explicitly makes a possible correlation between the initial concrete porosity, directly related to the specific properties of the RCAs and the resulting level of damage obtained in RAC samples.

Analytical Modeling of the Postcracking Response Observed in Hybrid Steel/Polypropylene Fiber-Reinforced Concrete.

This study deals with the analytical modeling of hybrid fiber-reinforced concretes (HyFRCs) made with a blend of different types of fibers characterized by different geometries and/or constitutive materials. The presented analytical formulation is oriented towards predicting the postcracking behavior of HyFRC and is mainly based on the well-known "cracked-hinge" model originally employed for standard fiber-reinforced concrete beams. The proposed model is validated by considering the experimental results obtained in a previous study carried out on HyFRCs mixtures made with a blend of steel and polypropylene fibers. Theoretical results are presented to demonstrate the predictive capabilities of the model to simulate the observed experimental behavior. The model performance is in very good agreement with the experimental data. Therefore, it has the capability to forecast the postcracking behavior of a generic HyFRC of given fiber contents depending on the actual proportion of the fiber blend. Finally, the proposed formulation can be applied as a computational aid to the design of HyFRC mixtures for structural purposes.

Early-Age Properties of Concrete Based on Numerical Hydration Modelling: A Parametric Analysis.

The early-age performances of cement-based mixtures are governed by cement hydration reactions. As a matter of fact, the heat generated during the setting and hardening phases due to the hydration processes increases the temperatures within the concrete elements while it starts developing its mechanical properties. These thermal stresses can cause the premature cracking of the cementitious matrix and undermine the long-term durability of the whole concrete element, especially in the case of massive structures where the dissipation of generated heat is more difficult. It is worth highlighting that the kinetics of cement hydration is mainly governed by the mixture composition; on the other hand, the heat generated during the setting and hardening is also influenced by the geometry of the element and/or its curing conditions. In this context, this study presents a numerical procedure intended to simulate the hydration reactions, and hence scrutinize the development of concrete properties at the early-age. Specifically, considering the variation of several factors, such as concrete strength class, element size and curing conditions, a comprehensive parametric analysis is presented herein, leading to the proposal of a simplified approach for both predicting the time evolution of the concrete mechanical performances at the early-age and mitigating the risk of premature cracking.

GeneSigDB: a manually curated database and resource for analysis of gene expression signatures.

GeneSigDB (http://www.genesigdb.org or http://compbio.dfci.harvard.edu/genesigdb/) is a database of gene signatures that have been extracted and manually curated from the published literature. It provides a standardized resource of published prognostic, diagnostic and other gene signatures of cancer and related disease to the community so they can compare the predictive power of gene signatures or use these in gene set enrichment analysis. Since GeneSigDB release 1.0, we have expanded from 575 to 3515 gene signatures, which were collected and transcribed from 1604 published articles largely focused on gene expression in cancer, stem cells, immune cells, development and lung disease. We have made substantial upgrades to the GeneSigDB website to improve accessibility and usability, including adding a tag cloud browse function, facetted navigation and a 'basket' feature to store genes or gene signatures of interest. Users can analyze GeneSigDB gene signatures, or upload their own gene list, to identify gene signatures with significant gene overlap and results can be viewed on a dynamic editable heatmap that can be downloaded as a publication quality image. All data in GeneSigDB can be downloaded in numerous formats including .gmt file format for gene set enrichment analysis or as a R/Bioconductor data file. GeneSigDB is available from http://www.genesigdb.org.

Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice.

Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two discrete kisspeptin neuronal populations, which are sexually dimorphic and are believed to make distinct contributions to reproductive physiology. Within these kisspeptin neuron populations, Kiss1 expression is directly regulated by sex hormones, thereby confounding the roles of sex differences and early activational events that drive the establishment of kisspeptin neurons. In order to better understand sex steroid hormone-dependent and -independent effects on the maturation of kisspeptin neurons, hypogonadal (hpg) mice deficient in GnRH and its downstream effectors were used to determine changes in the developmental kisspeptin expression. In hpg mice, sex differences in Kiss1 mRNA levels and kisspeptin immunoreactivity, typically present at 30 days of age, were absent in the anteroventral periventricular nucleus (AVPV). Although immunoreactive kisspeptin increased from 10 to 30 days of age to levels intermediate between wild type (WT) females and males, corresponding increases in Kiss1 mRNA were not detected. In contrast, the hpg arcuate nucleus (ARC) demonstrated a 10-fold increase in Kiss1 mRNA between 10 and 30 days in both females and males, suggesting that the ARC is a significant center for sex steroid-independent pubertal kisspeptin expression. Interestingly, the normal positive feedback response of AVPV kisspeptin neurons to estrogen observed in WT mice was lost in hpg females, suggesting that exposure to reproductive hormones during development may contribute to the establishment of the ovulatory gonadotropin surge mechanism. Overall, these studies suggest that the onset of pubertal kisspeptin expression is not dependent on reproductive hormones, but that gonadal sex steroids critically shape the hypothalamic kisspeptin neuronal subpopulations to make distinct contributions to the activation and control of the reproductive hormone cascade at the time of puberty.