ABSTRACT
Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with susceptibility to beta-human papilloma virus (HPV) infection. EV patients develop disseminated warts and non-melanoma skin cancer, mainly squamous cell carcinomas (SCC) that are locally aggressive. EV pathogenesis is not yet fully understood, but alterations in the p16 gene play a role in the pathogenesis of neoplasms caused by high-risk genital HPV. To explore its role in EV lesions, we compared p16 expression in SCC from patients with and without EV. Tissue microarray slides composed of 27 SCC from EV patients, and 35 from non-EV patients were stained with an anti-p16 antibody. Twenty (74%) EV tumors exhibited diffuse (nuclear and cytoplasmic) p16 expression, one (4%) displayed focal expression, and six (22%) displayed no p16 staining. Eleven (31%) SCC from non-EV patients presented diffuse p16 staining, 14 (40%) displayed focal expression and 10 (29%) did not express p16. The frequency of diffuse p16 expression was higher in EV tumors than in SCC from patients without EV. The frequency of diffuse p16 expression in moderately and poorly differentiated EV-SCC was similarly higher than non-EV tumors with the same degree of differentiation. The diffuse expression of p16 in EV-SCC suggests that changes in the p16 gene, probably resulting in a functionally defective protein, may be one factor determining the locally aggressive clinical behavior of SCC in young EV patients.
Subject(s)
Carcinoma, Squamous Cell/pathology , Cyclin-Dependent Kinase Inhibitor p16/metabolism , Epidermodysplasia Verruciformis/pathology , Papillomavirus Infections/pathology , Skin Neoplasms/pathology , Adult , Age Factors , Aged , Biopsy , Carcinoma, Squamous Cell/immunology , Carcinoma, Squamous Cell/virology , Disease Susceptibility/immunology , Epidermodysplasia Verruciformis/genetics , Epidermodysplasia Verruciformis/immunology , Female , Humans , Immunohistochemistry , Male , Papillomaviridae/isolation & purification , Papillomavirus Infections/immunology , Papillomavirus Infections/virology , Rare Diseases/genetics , Rare Diseases/immunology , Rare Diseases/pathology , Skin/pathology , Skin/virology , Skin Diseases, Genetic/genetics , Skin Diseases, Genetic/immunology , Skin Diseases, Genetic/pathology , Skin Neoplasms/immunology , Skin Neoplasms/virology , Tissue Array AnalysisABSTRACT
A síndrome dos ovários policísticos (SOP) é um distúrbio comum que atinge as mulheres na menacme e é caracterizado por anovulação crônica, síndrome androgênica e alteração ultrassonográfica característica. A SOP apresenta uma série de sinais dermatológicos que podem ser confundidos com aspectos fisiológicos da puberdade. O tratamento destas manifestações pode ser feito com drogas antiandrogênicas, além de tratamentos estéticos com laser e medicamentos tópicos.
The polycystic ovary syndrome (PCOS) is a common clinical problem affecting women in premenopausal women, characterized by ovulatory dysfunction, androgenic syndrome and ultrasound alterations. The PCOS presents dermatologic signals that may be diffi cult to diagnose because some features of the syndrome may be physiologic at this age. The treatment can be done with anti-androgenic drugs and esthetic treatments, such as laser and topic drugs.