A neglected reality of mass media during COVID-19: Effect of pandemic news on individual's positive and negative emotion and psychological resilience.

Numerous studies have demonstrated that mass media platforms are playing a crucial role in disseminating information about the COVID-19 pandemic. As media coverage of pandemic using frightening language has been speculated to induce emotional disturbances in people and fluctuations in their resilience level, this study was performed to explore the effect of COVID-19 related news on individual's emotions and resilience. It was hypothesized that altering the type of news would produce varying levels of emotions and resilience in participants. Both the recruitment of participants and the conduction of the study were done online in September when the pandemic hit the peak in India. Randomly assigned participants were exposed to three conditions: positive news (N = 56), negative news (N = 59), and neutral news (N = 60) related to COVID-19. Analyses revealed negative news significantly decreased positive emotions and resilience while positive news significantly reduced negative emotions and vice-versa. These finding suggest strong impact of mass media on individual's emotions and their own self-evaluation on resilience. The study highlights the responsibility of mass media and urges for bringing necessary changes in covering pandemic news and similar other uncertain situations in keeping people's emotions stable and increasing their psychological resilience.

Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India.

BACKGROUND & OBJECTIVES: In December 2019, a novel coronavirus (SARS-CoV-2) emerged in China and rapidly spread globally including India. The characteristic clinical observations and outcomes of this disease (COVID-19) have been reported from different countries. The present study was aimed to describe the clinico-demographic characteristics and in-hospital outcomes of a group of COVID-19 patients in north India. METHODS: This was a prospective, single-centre collection of data regarding epidemiological, demographic, clinical and laboratory parameters, management and outcome of COVID-19 patients admitted in a tertiary care facility in north India. Patient outcomes were recorded as death, discharge and still admitted. RESULTS: Data of 144 patients with COVID-19 were recorded and analyzed. The mean age of the patients was 40.1±13.1 yr, with 93.1 per cent males, and included 10 (6.9%) foreign nationals. Domestic travel to or from affected States (77.1%) and close contact with COVID-19 patients in congregations (82.6%) constituted the most commonly documented exposure. Nine (6.3%) patients were smokers, with a median smoking index of 200. Comorbidities were present in 23 (15.9%) patients, of which diabetes mellitus (n=16; 11.1%) was the most common. A significant proportion of patients had no symptoms (n=64; 44.4%); among the symptomatic, cough (34.7%) was the most common symptom followed by fever (17.4%) and nasal symptoms (2.15%). Majority of the patients were managed with supportive treatment with hydroxychloroquine and azithromycin given on a case-to-case basis. Only five (3.5%) patients required oxygen supplementation, four (2.8%) patients had severe disease requiring intensive care, one required mechanical ventilation and mortality occurred in two (1.4%) patients. The time to reverse transcription-polymerase chain reaction (RT-PCR) negativity was 16-18 days. INTERPRETATION & CONCLUSIONS: In this single-centre study of 144 hospitalized patients with confirmed COVID-19 in north India, the characteristic findings included younger age, high proportion of asymptomatic patients, long time to PCR negativity and low need for intensive care unit care.

Immunocytochemistry on scrape cellblock: An aid in the diagnosis of metastatic neoplasm with unknown primary: A series of four cases.

Scrape cellblock (SCB) is a novel technique to suggest possible primary site in fine-needle aspiration cytology (FNAC) smears from the liver, lung, and lymph nodes which are the common sites of metastasis of many primary tumors. Immunocytochemistry (ICC) on SCB averts the need of more invasive diagnostic procedures and gives a conclusive diagnosis. We present a series of four cases with unknown primary site, in which ICC was done on SCB to suggest possible primary site. Three of them were liver space-occupying lesions (SOL) and one from the periportal lymph node. In all four cases, wet-fixed smear for hematoxylin and eosin stain was prepared as routine procedure. FNAC was reported as metastatic adenocarcinoma in two and metastatic spindle cell neoplasm in one liver SOL. Periportal node was reported metastatic adenocarcinoma. Two hematoxylin and eosin-stained slides from each case with higher cellularity were used to scrape off the material to prepare SCB. ICC was put which gave conclusive diagnosis in all the cases. On ICC, two cases of metastatic carcinoma in the liver were diagnosed as metastatic neuroendocrine neoplasm from Gastrointestinal Tract and metastatic adenocarcinoma from the stomach. Spindle cell neoplasm of the liver was diagnosed as gastrointestinal stromal tumor from the stomach. Pancreatic head mass in metastatic periportal node was confirmed later by radiologic examination. SCB is a useful technique to make the best use of available material where reaspiration is difficult. ICC on SCB is of maximum utility to suggest possible primary sites in metastatic cases with unknown primary or where biopsy of the lesion is not possible.

Comparison of Procleix Ultrio Elite and Procleix Ultrio NAT Assays for Screening of Transfusion Transmitted Infections among Blood Donors in India.

Background. Introduction of nucleic acid testing (NAT) has helped in decreasing window period donations, resulting in increased safety of blood supplies. NAT combines the advantages of direct and highly sequence-specific detection of viral genomes. We analysed the performance of newer Procleix Ultrio Elite (PUE) and Procleix Ultrio assay (PUA) for the screening of the viral markers in our donor population. Material and Methods. 10,015 donor samples were screened by routine immunoassays and both versions of NAT. NAT yields detected were subjected to viral load estimation and to other serological markers. Results. A total of 21 NAT yields were detected; three were positive by both NAT systems, whereas 18 samples were reactive by PUE only. NAT yields include 18 HBV and 3 HCV yields, of which 17 HBV yields were occult infections and 1 was window period (WP) infection. All 3 HCV yields were WP infections. No HIV-1/HIV-2 yield was found. Conclusion. Efficient target capture chemistry in the new TMA assay version significantly improved sensitivity. NAT is superior to serological immunoassays for screening of the viral markers; and the efficient target capture system in the newer TMA assay, namely, the PUE system, has significantly improved sensitivity over the earlier versions.

Oral health status and awareness among tuberculosis patients in an Indian population.

BACKGROUND: Knowledge and awareness regarding oral health problems of tuberculosis patients are lacking among patients, physicians, as well as dental practitioners. AIM: This study aimed to assess the oral health status and awareness among the tuberculosis patients in an Indian population. METHODS: Study sample comprised of 210 tuberculosis patients and 210 nontuberculosis subjects. The tuberculosis patients were categorized into new patients (group A), previously treated (group B), and drug-resistant tuberculosis patients (group C). History of present problem and awareness about oral health was noted. Periodontal health status was ascertained using Community Periodontal Index (CPI). Other oral findings were also recorded. RESULTS: The results were analyzed statistically. 62.9% of total tuberculosis patients had one or more oral problems. Most common problem was tooth pain (34%). CPI score was significantly higher (p<0.05) for tuberculosis patients (2.94) than in control group (1.34). Mean CPI score for groups A, B, and C patients was 2.83, 2.91, and 3.09, respectively. CONCLUSION: This study suggests awareness of oral health status and oral manifestations of tuberculosis among physicians and dental professionals.