Surgical exploration for penetrating neck trauma - an audit of results in 145 patients.

BACKGROUND: Selective non-operative management (SNOM) is the current gold standard for the treatment of patients with penetrating neck trauma. The policy revolves around the liberal use of computed tomography angiography (CTA) in those patients who are haemodynamically stable, irrespective of the anatomical zone of injury, aiming at reducing the incidence of negative and non-therapeutic interventions and their potential complications. METHODS: A retrospective audit of results of patients who underwent immediate surgical exploration at the Chris Hani Baragwanath Academic Hospital in Soweto between January 2010 and December 2015 was performed. RESULTS: One-hundred and forty-five (145) patients, with a median age of 28 years (range 18-67 years), predominantly males (93.8%), underwent immediate exploration. Most injuries were caused by stab wounds (92.4%) and affected zone 2 (54.1%) on the left side of the neck (69.6%). The most common presentations were active haemorrhage (29.4%), shock (24.1%) and expanding haematoma (15.1%). A major vascular injury was found in 40%, and aero-digestive organ injury in 19.3%. The rate of negative-non-therapeutic exploration in this cohort was 4.1%. Complications were recorded in 7.6%, and the overall mortality was 9.6% secondary to early uncontrolled haemorrhage, sepsis and occlusive strokes. CONCLUSIONS: The utilisation of SNOM with strict criteria for selection of patients who require immediate surgical exploration versus investigations with CTA results in a low rate of non-therapeutic interventions.

Surgical site infection after penetrating abdominal trauma with bowel involvement: a comparison between HIV-seropositive and seronegative patients.

BACKGROUND: The influence of HIV-infection on surgical site infection (SSI) after surgery for penetrating abdominal trauma is not investigated and therefore not as yet elucidated. This prospective study was performed with the aim to compare the SSI rate in human immunodeficiency virus (HIV)-seropositive and HIV-negative patients and to identify other risk factors for this abdominal wound complication. METHOD: 98 patients who underwent small or large bowel resection and subsequent anastomosis due to penetrating abdominal trauma were included in the study. Injury related factors as well as demographical and physiological parameters, including HIV-status were analysed and superficial and deep SSI incidence rates were evaluated. RESULTS: Of the 98 patients, 23 patients (23%) were HIV-seropositive. The overall superficial SSI rate was 45% and the deep SSI rate was 15%. No significant difference in SSI (superficial or deep) in the HIV-seropositive and -negative group was demonstrated (superficial SSI HIV-pos vs HIV-neg: 61% vs 40%; p=0.172, deep SSI 22% vs 13%, p=0.276). Multivariate analysis identified five independent risk factors for SSI: postoperative CD4 count < 250 cells/µl, postoperative albumin < 30 g/L, relook operation, anastomotic leak and colonic anastomosis. CONCLUSION: HIV-infection is not an independent risk factor for developing SSI after penetrating abdominal trauma. Low postoperative CD4 count, irrespective of HIV status, low postoperative albumin, relook operation, anastomotic leak and colonic anastomosis are predictors for SSI irrespective of the HIV-serostatus. These factors should be considered in unison during the decision-making process of abdominal wound closure; planned secondary wound treatment or immediate application of negative pressure dressings in patients with a high-risk profile may decrease the hospital stay and the financial burden on the health care system.

[Update on gunshot wounds to extremities]. / Update zu Schussverletzungen der Extremitäten.

Due to recent rampage and terror attacks in Europe, gunshot wounds have become a focus of attention even though they are still rare in Europe. Approximately 50% of gunshot wounds affect the extremities and to understand the sequelae, a basic knowledge of wound ballistics is indispensable. The energy transmitted from the bullet to the tissue is responsible for the severity of the injury and is dependent on the type of weapon and ammunition. A differentiation is made between low-energy injuries caused, e.g. by pistols and high-energy injuries mostly caused by rifles. The higher energy transfer to the tissue in high-energy injuries, results in a temporary wound cavity in addition to the permanent wound channel with extensive soft tissue damage. High-energy gunshot fractures are also more extensive compared to those of low energy injuries. Debridement seems to be necessary for almost all gunshot wounds. Fractures should be temporarily stabilized with an external fixator due to contamination.

[Cardiac surgery in the elderly: perioperative care and operative strategies]. / Herzchirurgie bei betagten Patienten.

Caused by the age-dependent prevalence of cardiac diseases, the number of cardiac surgical interventions to geriatric patients is increasing. High life quality and life expectancy can be reached by cardiac operations. The advantage of cardiac surgical interventions is the decade's long positive effect. Accordingly also elderly benefit from complete revascularisation and from aortic valve replacement with biological prosthesis, which rarely degenerate in old age. A weak point is the surgical trauma, which can be reduced by less-invasive methods, such as OPCAB with aortic non-touch-technique, resulting in less than 1 % stroke. The indications for heart operations will be based on age-independent evidence-based guidelines. The decision for surgery is influenced by the expectation of the risk. This is defined by the co-morbidities and to lesser extent by the age per se. The operation risk can be calculated by risk-scores and hospital-specific data. The patient's expectations from the operation and his ability to overcome the accompanying stress must be thoroughly assessed. The operation must take place electively and at the right time. A good nutritional status and preoperative optimization of the organ functions are decisive for the prognosis. The blood-sugar-level must be optimized; thyroid function, (hidden) infections, anaemia and depression must be excluded or treated. The required screening tests should have been done already by the family doctor. The elderly are postoperatively susceptible to complications; especially low cardiac output, renal failure, respiratory insufficiency and stroke. Subsequently they need more intensive care.

[Abscess-forming and necrotizing aspergillus myocarditis in a surgical intensive care patient--a rare occurrence]. / Abszedierende und nekrotisierende Aspergillusmyokarditis bei einem chirurgischen Intensivpatienten--ein seltenes Ereignis.

The case of an 89 year old patient is reported, in whom an aspergillus myocarditis was unexpectedly found at autopsy. Preoperatively, the patient showed no risk factors for an invasive mycosis. 5 days after uncomplicated surgery he developed septic shock due to peritonitis. After surgery and intensive care therapy the patient recovered initially. 23 days after the first operation the patient suddenly developed catecholamin-resistant myocardial failure and died. Ten days before, aspergillus spec. was found in a specimen of bronchial secretion. This finding was interpreted as colonisation and not treated.

[Acute myocardial infarction after blunt polytrauma -- successful coronary intervention]. / Akuter Myokardinfarkt bei stumpfem Polytrauma mit erfolgreicher katheterinterventioneller Therapie.

Acute myocardial infarction following blunt chest trauma is a well reported but rare finding. Especially in severely injured patients the optimal therapy of the myocardial infarction is not well established, since anticoagulants, platelet aggregation inhibitors or thrombolytics are frequently contraindicated under these conditions. We report a case of a 41-year-old man, who presented with an acute myocardial infarction in combination with a severe polytrauma (multiple rib fractures, hematothorax, pelvic bone fractures, multiple injuries of intestinal organs) after a motorcycle accident with a blunt chest and abdominal trauma. After surgical treatment of the injuries of the bones and the intestinal organs a coronary angiography was immediately performed. The left anterior descending and the circumflex coronary artery were occluded in the mid-portion of the vessels. Coronary recanalization by PTCA and the implantation of coronary stents were successful in both vessels. Despite of a non-optimal blood flow after recanalization and stenting in one vessel (LAD TIMI II flow after recanalization), and a non-optimal accompanying medical therapy, during and after intervention (intravenous heparin starting 8 hours after the coronary intervention and platelet inhibitors starting 4 days after the intervention) the coronary angiogram after 2 months documented both vessels patent without a reocclusion or a restenosis. The case report documents, that in traumatic myocardial infarctions the treating of both, the attending injuries and the myocardial ischemia, is feasible. Early coronary angiography and coronary interventions, with or without stent-implantation, are indicated, even in cases in which an adequate accompanying medical therapy with heparin and platelet inhibitors is contraindicated.

[Acute myocardial infarct in pheochromocytoma crisis. Early coronary angiography findings and echocardiography follow-up]. / Akuter Myokardinfarkt bei der Phäochromozytom-Krise. Frühe koronarangiographische Befunde und echokardiographischer Verlauf.

A myocardial infarction is a rare complication of a pheochromocytoma. A pheochromo-cytoma crisis may occur spontaneously, during pregnancy, or may be induced by a local trauma of the tumor or by drugs. We present a case report of a 41-year-old woman without anamnestic episodes of hypertension or angina pectoris. During angiography of the mesenteric arteries for further diagnostics of a sonographically suspected liver tumor, she developed an acute pulmonary edema and a cardiogenic shock with the electro- and echocardiographic findings of a large anterolateral-apical-diaphragmal myocardial infarction. The immediate coronary angiography 90 min after the onset of the myocardial infarction showed normal coronary arteries with normal coronary blood flow of the arteries supplying myocardial areas with akinetic segments and those arteries supplying hyperkinetic segments. The blood catecholamine levels at this time were excessively elevated. The left ventricular function improved to almost normal within the next 4 weeks with the beginning of the improvement already before the abdominal tumor was surgically removed at day five. The histology documented a pheochromocytoma with acute necrosis. The early invasive findings support the hypothesis that a reversible spasm of several epicardial arteries and not a direct toxic effect of catecholamines could have been the cause of the small myocardial infarction and the observed large myocardial stunning.

[Blunt chest trauma with severe pulmonary contusion and traumatic myocardial infarction]. / Stumpfes Thoraxtrauma mit schwerer Lungenkontusion und traumatischem Myokardinfarkt.

In the literature the incidence of cardiac involvement in blunt chest trauma varies considerably. This reflects the diagnostic problems encountered in polytraumatised patients. We report the case of an 18 year old man who suffered bilateral pulmonary contusion and traumatic myocardial infarction following a motorbike accident. The myocardial infarct was diagnosed by means of ECG, cardiac enzymes and echocardiography. When the diagnosis was made the time for successful interventional treatment had lapsed. A coronary angiography was performed after stabilisation which revealed a proximal dilatation of the left anterior descending artery. Left ventricular function was severely impaired (ejection fraction 26%). Due to the pulmonary contusion respiratory support was required for 14 days. The course was further complicated by left ventricular failure with low output.

Acute success rates of percutaneous transluminal coronary angioplasty in the treatment of chronic complete occlusions with use of the 0.014 magnum Meier wire.

The 0.014 inch magnum Meier wire was used as the primary tool for recanalization of chronic total coronary artery occlusions in 230 consecutive patients treated by a single operator over a 3-year period. Exclusive use of the magnum wire resulted in an acute success rate of 80.9% in all occlusions and 64.7% in occlusions with a duration of >6 months. The complication rate of this procedure was extremely low with only one nontransmural myocardial infarction occurring. There were no vessel perforations, no in-hospital deaths, and no need for acute surgery. After failure to recanalize with the magnum wire, various other devices (conventional stiff guidewires, jagwire, crosswire) were used resulting in only six additional successful recanalizations but also in two vessel perforations with spontaneous closure of the perforation hole. Therefore, the 0.014-inch magnum Meier recanalization wire is highly effective for recanalization of chronic coronary artery occlusions, if used as the primary tool by an experienced operator, and is associated with an extremely low complication rate.

Combination of aneurysm and myocardial bridging at the same site of a coronary artery in a patient with obstructive hypertrophic cardiomyopathy.

This case report describes the rare finding of myocardial bridging and a coronary aneurysm in the same coronary artery segment of a 57-year-old patient with obstructive hypertrophic cardiomyopathy. At the site of the aneurysm in the proximal LAD, the myocardial bridging resulted in an almost normal vessel diameter during systole with an aneurysmatic expansion of the vessel during diastole. This accidental finding does not necessarily require special therapy, since the underlying coronary aneurysm is small, with a low risk of thrombus formation or rupture, but it is big enough to prevent a coronary obstruction due to the myocardial bridging.

[Dissection of the sinus valsalvae aortae as a complication of coronary angioplasty]. / Dissektion des Sinus valsalvae aortae als Komplikation der Koronarangioplastie.

The localized dissection of the aortic sinus of valsalvae is a rare complication of coronary angioplasty involving mainly the right coronary artery. In all previously published case reports (n = 10), a coronary dissection provided the entry door with subsequent retrograde progression of the dissection into the aortic root. In our case of a 75 year old female patient with symptomatic three vessel disease, a chronic occlusion of a proximal RCA could not be passed by a coronary guide wire. During the procedure an aneurysm of the aortic sinus occurred near the ostium of the RCA. The patient was referred for immediate aortocoronary bypass surgery. The inspection of the aortic sinus showed, as the entry of the dissection, a small puncture hole, adjacent to the ostium of the RCA, probably caused by the stiff 0.014 coronary guide wire, and no retrograde dissection of the right coronary artery. The localized dissection could easily be fixed by a prolene suture during the bypass surgery procedure with an uncomplicated postoperative course. If the entry of the dissection is within the coronary artery, forced contrast injections and balloon inflations promote its propagation and should be avoided. If the entry could be sealed by an intracoronary stent and the aneurysm remained localized, confirmed by echocardiographic controls, the aneurysm tends to resolve spontaneously in the first month without need for surgery. A progression of the aneurysm into the ascending aorta or a failure of an entry sealing with a stent is an indication for urgent surgical treatment.

[Comparison of the negative inotropic properties of nifedipine and nisoldipine using isovolumetric contractile parameters of the rat in vivo]. / Vergleich der negativ inotropen Eigenschaften von Nifedipin und Nisoldipin unter Verwendung isovolumetrischer Kontraktilitätsparameter bei der Ratte in vivo.

The vasoselectivity of new dihydropyridine calcium antagonists is much higher as compared to their prototype substance nifedipine. To investigate whether an equihypotensive dose of a new dihydropyridine has less negative inotropic properties in an intact circulation, nifedipine (NIF) and nisoldipine (NIS) were infused intravenously in an open-chest, anaesthetized rat model. The maximal isovolumic left ventricular pressure (LVPiso) and the maximal isovolumic rate of change of LV-pressure (dp/dtmaxiso) were determined to achieve load independent parameters of LV contractility. To evaluate the effect of the infused volume, the stability of the preparation and the hemodynamic effects of the drug-solvent, two groups with either infusion of isotonic NaCl-solution or 20% ethanol served as controls. NIF and NIS were infused in three equihypotensive doses within 7 min (NIF 250, 500, 1000 micrograms/kg; NIS 12.5, 25, 50 micrograms/kg). The decrease of the peripheral resistance of these doses was 74 +/- 6, 67 +/- 6, and 58 +/- 7% for NIF, and 78 +/- 7, 65 +/- 8, and 56 +/- 7% for NIS (p < 0.001 for all groups). In the control groups the afterload remained unchanged. NIF-infusion resulted in a dose-dependent decrease of LVPiso at the end of the infusion period (in percent of controls: NIF250 88 +/- 3%, p < 0.001; NIF500 74 +/- 3%, p < 0.001) as well as 15 min after the end of the infusion. In the same way dp/dtmaxiso decreased significantly after NIF at the end of infusion (NIF 250 82 +/- 6%, p < 0.001; NIF500 61 +/- 8%, p < 0.001) and 15 min after the end of the infusion. After NIS-infusion the contractility parameters decreased slightly after the higher dosage (25 micrograms/kg) at the end of the infusion period only (LVPiso 96 +/- 3%, p < 0.01; dp/dtmaxiso 93 +/- 5%, p < 0.01). There was no depressive effect on the isovolumic contractility parameters at the end of infusion of the lower dosage and 15 min after the drug-infusion of all dosages of NIS. Therefore, nisoldipine, as an example of a new dihydropyridine, has significantly less negative inotropic properties over a wide range of doses as compared to nifedipine in equihypotensive doses.

[Comparison of the cardiodepressive effects of nifedipine, isradipine, nisoldipine and felodipine in patients with coronary heart disease]. / Vergleich der kardiodepressiven Effekte von Nifedipin, Isradipin, Nisoldipin und Felodipin bei Patienten mit koronarer Herzerkrankung.

To compare the negative inotropic effects of the four dihydropyridine-calcium-channel-blockers nifedipine (NIF), isradipine (ISR), nisoldipine (NIS) and felodipine (FEL) in man, the drugs were infused within 30 min intravenously in an equihypotensive dosage (NIF 2 mg, ISR 0.5 mg, NIS 0.5 mg, FEL 0.6 mg; 10 patients in each group) in patients with coronary heart disease. As a control, an additional 10 patients received isotonic saline solution following an identical protocol. The afterload reduction was submaximal (reduction of peripheral resistance: NIF -23 +/- 9%, ISR -24 +/- 10%, NIS -28 +/- 6%, FEL -27 +/- 6%; no significant difference for group comparison) with a similar kinetic and a steady state of the afterload reduction after one-half of the infusion period to achieve a comparable sympathetic reflex activation. Preload parameters (PAP, LVEDP) were unchanged in all groups. A reflex tachycardia occurred in all treatment groups after 15 min of drug infusion. Due to its negative chronotropic properties, the reflex tachycardia was significantly attenuated after isradipine as compared to the other drugs (heart-rate changes: NIF +13 +/- 7%, p < 0.01; ISR +4 +/- 7%, not significant; NIS +20 +/- 10%, p < 0.01; FEL +17 +/- 12%, p < 0.01). Because of the baroreflex and sympathetic reflex activation the left-ventricular dp/dtmax increased after isradipine (+14 +/- 10%, p < 0.01) and nisoldipine (+16 +/- 13%, p < 0.01). The lack of a significant dp/dtmax increase in spite of a comparable afterload reduction after felodipine (+5 +/- 8%, not significant) or nifedipine (-3 +/- 6%, not significant) must be a consequence of the cardiodepressive properties of these drugs. Therefore, in an equihypotensive dosage, the strongest negative inotropic effects were observed after nifedipine, lesser effects after felodipine (p < 0.03), and the weakest cardiodepressive effects after isradipine (p < 0.01) and nisoldipine (p < 0.01). For clinical applications the lesser cardiodepressive properties of the new dihydropyridine-derivatives should be advantageous in patients with already reduced left-ventricular performance or for use in combination with other negative inotropic drugs, e.g., betablockers.

[Acute and long-term results of coronary Excimer laser angioplasty]. / Akut- und Langzeitergebnisse der koronaren Excimer-Laserangioplastie.

Laser and catheter technology have been considerably improved within the first 2 years of the clinical use of coronary excimer laser angioplasty. Furthermore, patient selection has changed due to increasing operator experience. We report on the acute- and long-term results achieved in 163 patients in three subgroups with different system parameters and catheter technology. In the initial series 1 (N:60) a prototype catheter with a diameter of 1.4 mm was used. In series 2 and 3, we employed improved transmission devices with 1.3, 1.5 or 1.8 mm. In series 3 the pulsewidth was increased from 60 ns to 115 ns. The target vessel was the LAD in 68%, the LCX in 10%, and the RCA in 21%. According to the AHA/ACC Lesion classification there were 13% type A, 26% type B1, 55% type B2, and 5% type C lesions. Stand-alone laser angioplasty was performed in 23/60 (38%), 24/40 (60%), and 34/64 (53%) in series 1, 2, and 3, respectively. Additional balloon angioplasty was necessary in 32, 11, and 21 interventions. Failure of laser angioplasty occurred in five patients of series 1 and 2, and nine patients of series 3. Frequently observed complications included coronary spasm in 18 to 32%, dissections in 16% to 33%, and vessel closure in 18 to 27%. Myocardial infarction occurred in three patients in the first and one patient of the second and third series. There was one in-hospital death in series 1 and 2.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of heart rate on transmitral flow velocity profile and Doppler measurements of mitral valve area in patients with mitral stenosis.

To study the effect of heart rate changes on Doppler measurements of mitral valve area atrial pacing was performed in 14 patients with mitral stenosis and sinus rhythm. Continuous wave Doppler and haemodynamic measurements were performed simultaneously at rest and during pacing-induced tachycardia. (1) Mitral valve area was determined using the conventional pressure half time method. (2) Additionally, mitral valve area was calculated with a combined Doppler and thermodilution technique according to the continuity equation. (3) Simultaneous invasive measurements were used for calculation of the mitral valve area according to the Gorlin formula. With increasing heart rate (69 +/- 13-97 +/- 15-114 +/- 13 beats min-1) mitral valve area either determined by the continuity equation (1.0 +/- 0.2-1.0 +/- 0.3-1.1 +/- 0.4 cm2) or the Gorlin formula (1.2 +/- 0.3-1.2 +/- 0.4-1.3 +/- 0.4 cm2) remained constant. Both methods correlated closely not only at rest (r = 0.88, SEE = 0.11 cm2, P less than 0.001), but also during atrial pacing (first level: r = 0.95, SEE = 0.10 cm2, P less than 0.001, second level: r = 0.95, SEE = 0.13 cm2, P less than 0.001). In contrast, mitral valve area calculated according to the pressure half time method increased significantly during atrial pacing (1.0 +/- 0.3-1.8 +/- 0.5-2.0 +/- 0.5 cm2).(ABSTRACT TRUNCATED AT 250 WORDS)

Success rate and incidence of restenosis following coronary excimer laser angioplasty: results of a single center experience.

The initial single center experience of percutaneous coronary excimer laser angioplasty is described for the first three series of 147 patients. Sixty patients were treated with a prototype 1.4-mm laser catheter, 40 patients with improved transmission devices, and the third series of 47 patients with an increased pulse width of the laser system allowing improved energy transmission. In 17 patients (12%) laser angioplasty could not be initiated due to inability to cross the lesion with the guidewire or to place the catheter coaxially within the vessel. In 32 patients (58%) of series 1, 11 patients (31%) of series 2, and 17 patients (43%) of series 3, additional balloon dilatation following laser treatment was necessary due to vessel closure (24%) or due to an insufficient angiographic result (35%). There was one death in series 1 (2%) and 2 (3%) each, one perforation in series 2 (3%), two transmural myocardial infarctions in series 1 (4%), and one myocardial infarction in series 2 (3%). During the 6-month follow-up period one patient in series 2 (2%), and one patient in series 3 (3%) died. Angiographic restenosis was found in 22, 12, and 11 patients of series 1 (40%), 2 (34%), and 3 (27%), respectively. No patient developed a transmural myocardial infarction. Thus, percutaneous coronary excimer laser angioplasty can be performed as a safe and feasible procedure in patients with coronary artery disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Value of a modified continuity equation method to quantify mitral valve area in patients with mitral stenosis and sinus rhythm.

To quantify valve area in mitral stenosis, a modified continuity equation method using continuous wave Doppler and thermodilution measurements was applied. In 14 patients with mitral stenosis and sinus rhythm (age: 49 +/- 11 years), transmitral flow velocity was recorded by continuous wave Doppler during right and left heart catheterization. Mitral valve area was calculated by three different methods: 1. According to the continuity equation, stroke volume (thermodilution technique) was divided by the registered time velocity integral of the mitral stenotic jet (continuous wave Doppler). 2. Mitral valve area was calculated by the pressure half-time method. 3. Simultaneous pulmonary capillary wedge and left ventricular pressure measurements were used for determination of mitral valve area according to the Gorlin formula. The mitral valve area determined by application of the continuity equation (y) showed a close correlation to the valve area calculated by the Gorlin equation (x): y = 0.73x + 0.12, SEE = 0.11 cm2, r = 0.88, P less than 0.001. In contrast, the correlation between mitral valve area determined by pressure half-time (y) and the Gorlin formula (x) was not as good: y = 0.77x + 0.11, SEE = 0.26 cm2, r = 0.65, P less than 0.05. Thus, the continuity equation method using combined continuous wave Doppler and thermodilution technique allows a valid determination of mitral valve area. In patients with mitral stenosis and sinus rhythm, this technique is superior to the noninvasive determination of mitral valve area by the conventional pressure half-time method.

Intraoperative valvuloplasty in calcific aortic stenosis: a study comparing the mechanism of a novel expandable device with conventional balloon dilatation.

In selected patients with calcific aortic stenosis, balloon valvuloplasty is an intermediate alternative to surgery. The effect of balloon valvuloplasty to increase valve area, however, is limited and the restenosis rate is high during follow-up. To improve the results and reduce the complication rate, a new device for valvuloplasty of calcific aortic stenosis was developed. This system consists of three expandable prongs mounted on a freely movable catheter tip. To evaluate the efficacy of this new device, valvuloplasty was performed in 10 patients with severe aortic stenosis intraoperatively just prior to valve replacement. Comparison was made with the results of conventional balloon dilatation performed in an additional 20 patients during surgery. Using the new device, the relative orifice area increased from 10 +/- 3% before to 20 +/- 6% following intervention. However, in only one patient was a considerable increase of static valve area (greater than 15%) found. The results were comparable to the effect of conventional balloon dilatation, which led to an increase of orifice area from 12 +/- 7% to 24 +/- 10%. With both systems, the best results were achieved in patients with aortic stenosis and significant commissural fusion. In contrast, in bicuspid or tricuspid valves without fused commissures the effect of the intervention was limited. Because complete obstruction of the aortic valve does not occur during dilatation, this new device might be superior to conventional balloon dilatation. Preselection of patients according to the morphology of the valve seems mandatory to improve the success and reduce the complication rate of valvuloplasty in aortic stenosis.

Effects of intracoronary nitroglycerin on lumen diameter during early follow-up angiography after coronary excimer laser atherectomy.

The incidence of coronary vasospasm during and following excimer laser atherectomy is considerable. The aim of this study was to investigate vasoconstriction of the target vessel during early follow-up angiography. In 50 patients an angiogram was performed 24 hours after intervention. Nineteen patients were treated with stand-alone laser atherectomy (group I), another 19 with laser and additional balloon angioplasty (group II) and 12 with balloon angioplasty alone (group III). Lumen diameter and percent stenosis before and after intracoronary application of 0.1 mg nitroglycerin were determined. The differences were compared between groups I, II and III, and for patients with (N = 14) and without (N = 24) vasospasm during laser atherectomy. There was a significant increase in lumen diameter, of 0.17 +/- 0.28 mm, after nitroglycerin in group I, of 0.18 +/- 0.29 mm in group II (P = 0.02) and of 0.03 +/- 0.21 mm in group III (ns). In patients with vasospasm during laser atherectomy the average increase in lumen diameter was 0.28 +/- 0.24 mm (P less than 0.01), and in patients without vasospasm 0.12 +/- 0.29 mm (P = 0.09). We conclude that one day after coronary excimer laser atherectomy intracoronary nitroglycerin significantly affects lumen diameter at the site of previous stenosis, an effect undetectable after balloon angioplasty. Thus, vasoconstriction after excimer laser ablation seems to be a common phenomenon and is prolonged in patients with vasospasm during the previous intervention.

[Effect of acute short-term ischemia during PTCA on the function of the right ventricle]. / Einfluss akuter kurzzeitiger Ischämie während PTCA auf die Funktion der rechten Herzkammer.

To determine whether a transient ischemia of the right ventricle leads to right ventricular impairment and whether RV function can also be influenced by septal ischemia caused by an occlusion of the left anterior descending coronary artery (LAD), RV function before and at the end of 60 s of ischemia during PTCA was assessed in 15 patients with single-vessel disease of either the right coronary artery (RCA, n = 10) or the LAD (n = 5). The RV-enddiastolic pressure and the pulmonary capillary wedge pressure (PCW) were recorded continuously. The RV ejection fraction was determined from ventriculograms performed before and during coronary occlusion. An increase of RVEDP from 3.7 +/- 1.2 to 8.3 +/- 1.8 mm Hg (p less than or equal to 0.001) and a decrease of the RV-ejection fraction from 52 +/- 3 to 33 +/- 8% (p less than or equal to 0.001) occurred during RCA occlusion with a predominant ischemia of the RV free wall only, and not during LAD occlusion with left ventricular and septal ischemia. The extent of the RV dysfunction was independent of an additional increase of RV afterload (PCW increase). Comparable to ischemic effects on left ventricular function, an acute right ventricular myocardial ischemia results in a severe RV contractile failure.