ABSTRACT
The role of bacterial infections as potential triggers for chronic rheumatic diseases is well-documented. Oral infections such as periodontitis may play a particularly important role in the development of autoimmune diseases, with the oral cavity serving as a reservoir for pathogenic bacteria. These bacteria may trigger dysregulatory immune responses through mechanisms like molecular mimicry, whereby bacterial peptides resemble self-peptides. Genetic factors may also predispose individuals to specific autoimmune diseases, most notably human leukocyte antigen B27 (HLA-B27) in the case of ankylosing spondylitis as well as other rheumatic diseases. We present a case of a 23-year-old woman with reactive arthritis resulting from a postoperative infection. The patient presented with bilateral shoulder pain, decreased range of motion, worsening lower back pain, and mandibular pain at the site of a recent third molar extraction. Though initially diagnosed with rheumatoid arthritis, the patient experienced rapid and dramatic improvements following surgical treatment of the unresolved infection, demonstrating a causative or temporally related association between oral infections and chronic systemic autoimmune disease. This case provides useful evidence regarding causal mechanisms for the connections between chronic autoimmune diseases and oral bacterial infection, illustrating how oral infection may serve as a causative factor for reactive arthritis. We suggest that this implicates bacteria normally present in oral microflora as a potential source of the antigens involved in triggering systemic inflammation, especially those already associated with other autoimmune diseases, such as Klebsiella pneumoniae in the case of ankylosing spondylitis. Based on prior publications linking self-peptides with homologies in such bacteria, we speculate on mechanisms underlying this connection, with particular attention to molecular mimicry. Clinicians should be aware of the close connection between certain rheumatic diseases (such as reactive arthritis) and bacterial infection, particularly of the oral cavity; such awareness should inform strategies for treatment and prevention of arthritic disease.
ABSTRACT
BACKGROUND: COVID-19 is an international health crisis of particular concern in the United States, which saw surges of infections with the lifting of lockdowns and relaxed social distancing. Young adults have proven to be a critical factor for COVID-19 transmission and are an important target of the efforts to contain the pandemic. Scalable digital public health technologies could be deployed to reduce COVID-19 transmission, but their use depends on the willingness of young adults to participate in surveillance. OBJECTIVE: The aim of this study is to determine the attitudes of young adults regarding COVID-19 digital surveillance, including which aspects they would accept and which they would not, as well as to determine factors that may be associated with their willingness to participate in digital surveillance. METHODS: We conducted an anonymous online survey of young adults aged 18-24 years throughout the United States in June 2020. The questionnaire contained predominantly closed-ended response options with one open-ended question. Descriptive statistics were applied to the data. RESULTS: Of 513 young adult respondents, 383 (74.7%) agreed that COVID-19 represents a public health crisis. However, only 231 (45.1%) agreed to actively share their COVID-19 status or symptoms for monitoring and only 171 (33.4%) reported a willingness to allow access to their cell phone for passive location tracking or contact tracing. CONCLUSIONS: Despite largely agreeing that COVID-19 represents a serious public health risk, the majority of young adults sampled were reluctant to participate in digital monitoring to manage the pandemic. This was true for both commonly used methods of public health surveillance (such as contact tracing) and novel methods designed to facilitate a return to normal (such as frequent symptom checking through digital apps). This is a potential obstacle to ongoing containment measures (many of which rely on widespread surveillance) and may reflect a need for greater education on the benefits of public health digital surveillance for young adults.
