ABSTRACT
BACKGROUND/AIM: The aim of this study was to determine the association between total triiodothyronine (T3), free fraction of thyroxin (FT4), and thyrotropin (TSH) levels with prostate cancer histopathological features. PATIENTS AND METHODS: Blood samples from 140 patients with prostate cancer were analyzed preoperatively and stratified according to postoperative histopathological differentiation. The first group (N=62) included patients with prostate cancer Grade Groups (GG) 1-2, while the second group (N=63) included patients with prostate cancer GG 3-5. RESULTS: T3 levels were significantly higher in patients with prostate cancer GG 3-5 (p=0.047). There was no significant difference in the FT4 and TSH levels between the two groups (p=0.680 and 0.801, respectively). T3 levels were positively correlated with tumor percentage involvement (TPI) (p=0.002), and pT stage (p=0.047) on definitive pathology. CONCLUSION: Higher T3 levels are associated with several indicators of prostate cancer histopathological aggressiveness.
Subject(s)
Prostatic Neoplasms/surgery , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/blood , Aged , Humans , Male , Middle Aged , Neoplasm Grading , Neoplasm Staging , Preoperative Period , Prospective Studies , Prostate-Specific Antigen/blood , Prostatectomy/methods , Prostatic Neoplasms/blood , Prostatic Neoplasms/pathologyABSTRACT
We report a rare case of spontaneous intraperitoneal bladder rupture following normal vaginal delivery without concomitant uterine rupture. Key diagnostic clinical features were acute renal failure, new-onset ascites and bowel ileus with urosepsis. Laparotomy and bladder repair with omentum patch were performed with no adverse outcome reported.
Subject(s)
Abdomen, Acute/etiology , Delivery, Obstetric , Puerperal Disorders/etiology , Urinary Bladder Diseases/etiology , Abdomen, Acute/diagnosis , Acute Kidney Injury/diagnosis , Acute Kidney Injury/etiology , Adult , Ascites/diagnosis , Ascites/etiology , Diagnosis, Differential , Female , Humans , Ileus/diagnosis , Ileus/etiology , Peritonitis/diagnosis , Peritonitis/etiology , Pregnancy , Puerperal Disorders/diagnosis , Risk Factors , Rupture, Spontaneous , Urinary Bladder Diseases/diagnosisABSTRACT
- Infections are well-known complications of radical prostatectomy. In the United States and Europe, the rates of surgical site infections are generally less than 1% and of other infections up to 3%. We report a case of a 62-year-old man who developed severe sepsis with renal insufficiency, paralytic ileus and polyserositis after radical prostatectomy, as a consequence of probable quinolone-resistant bacterial infection. Computed tomography of the abdomen and chest showed polyserositis with bilateral pleural and peritoneal effusions. Treatment with meropenem and other supportive measures resulted in good clinical outcome. This case suggested that severe sepsis with exudative polyserositis was probably caused by mobilization of an infective agent (bacterium) during bladder neck dissection as part of open radical prostatectomy.
