Indicators to measure implementation and sustainability of nursing best practice guidelines: A mixed methods analysis.

Background: The use of best practice guidelines (BPGs) has the potential to decrease the gap between best evidence and nursing and healthcare practices. We conducted an exploratory mixed method study to identify strategies, processes, and indicators relevant to the implementation and sustainability of two Registered Nurses' Association of Ontario (RNAO) BPGs at Best Practice Spotlight Organizations® (BPSOs). Methods: Our study had four phases. In Phase 1, we triangulated two qualitative studies: a) secondary analysis of 126 narrative reports detailing implementation progress from 21 BPSOs spanning four sectors to identify strategies and processes used to support the implementation and sustainability of BPGs and b) interviews with 25 guideline implementers to identify additional strategies and processes. In Phase 2, we evaluated correlations between strategies and processes identified from the narrative reports and one process and one outcome indicator for each of the guideline. In Phase 3, the results from Phases 1 and 2 informed indicator development, led by an expert panel. In Phase 4, the indicators were assessed internally by RNAO staff and externally by Ontario Health Teams. A survey was used to validate proposed indicators to determine relevance, feasibility, readability, and usability with knowledge users and BPSO leaders. Results: Triangulation of the two qualitative studies revealed 46 codes of implementation and sustainability of BPGs, classified into eight overarching themes: Stakeholder Engagement, Practice Interventions, Capacity Building, Evidence-Based Culture, Leadership, Evaluation & Monitoring, Communication, and Governance. A total of 28 structure, process, or outcome indicators were developed. End users and BPSO leaders were agreeable with the indicators according to the validation survey. Conclusions: Many processes and strategies can influence the implementation and sustainability of BPGs at BPSOs. We have developed indicators that can help BPSOs promote evidence-informed practice implementation of BPGs.

Cells of the Blood-Brain Barrier: An Overview of the Neurovascular Unit in Health and Disease.

The brain is endowed with highly specialized vasculature that is both structurally and functionally unique compared to vasculature supplying peripheral organs. The blood-brain barrier (BBB) is formed by endothelial cells of the cerebral vasculature and prevents extravasation of blood products into the brain to protect neural tissue and maintain a homeostatic environment. The BBB functions as part of the neurovascular unit (NVU), which is composed of neurons, astrocytes, and microglia in addition to the specialized endothelial cells, mural cells, and the basement membrane. Through coordinated intercellular signaling, these cells function as a dynamic unit to tightly regulate brain blood flow, vascular function, neuroimmune responses, and waste clearance. In this chapter, we review the functions of individual NVU components, describe neurovascular coupling as a classic example of NVU function, and discuss archetypal NVU pathophysiology during disease.

Increased 20-HETE Signaling Suppresses Capillary Neurovascular Coupling After Ischemic Stroke in Regions Beyond the Infarct.

Neurovascular coupling, the process by which neuronal activity elicits increases in the local blood supply, is impaired in stroke patients in brain regions outside the infarct. Such impairment may contribute to neurological deterioration over time, but its mechanism is unknown. Using the middle cerebral artery occlusion (MCAO) model of stroke, we show that neuronal activity-evoked capillary dilation is reduced by ∼75% in the intact cortical tissue outside the infarct border. This decrease in capillary responsiveness was not explained by a decrease in local neuronal activity or a loss of vascular contractility. Inhibiting synthesis of the vasoconstrictive molecule 20-hydroxyeicosatetraenoic acid (20-HETE), either by inhibiting its synthetic enzyme CYP450 ω-hydroxylases or by increasing nitric oxide (NO), which is a natural inhibitor of ω-hydroxylases, rescued activity-evoked capillary dilation. The capillary dilation unmasked by inhibiting 20-HETE was dependent on PGE2 activation of endoperoxide 4 (EP4) receptors, a vasodilatory pathway previously identified in healthy animals. Cortical 20-HETE levels were increased following MCAO, in agreement with data from stroke patients. Inhibition of ω-hydroxylases normalized 20-HETE levels in vivo and increased cerebral blood flow in the peri-infarct cortex. These data identify 20-HETE-dependent vasoconstriction as a mechanism underlying capillary neurovascular coupling impairment after stroke. Our results suggest that the brain's energy supply may be significantly reduced after stroke in regions previously believed to be asymptomatic and that ω-hydroxylase inhibition may restore healthy neurovascular coupling post-stroke.

Spatially mapped single-cell chromatin accessibility.

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in complex tissues, however, spatial orientation is lost. Here, we present single-cell combinatorial indexing on Microbiopsies Assigned to Positions for the Assay for Transposase Accessible Chromatin, or sciMAP-ATAC, as a method for highly scalable, spatially resolved, single-cell profiling of chromatin states. sciMAP-ATAC produces data of equivalent quality to non-spatial sci-ATAC and retains the positional information of each cell within a 214 micron cubic region, with up to hundreds of tracked positions in a single experiment. We apply sciMAP-ATAC to assess cortical lamination in the adult mouse primary somatosensory cortex and in the human primary visual cortex, where we produce spatial trajectories and integrate our data with non-spatial single-nucleus RNA and other chromatin accessibility single-cell datasets. Finally, we characterize the spatially progressive nature of cerebral ischemic infarction in the mouse brain using a model of transient middle cerebral artery occlusion.

Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?

The neurovascular unit, consisting of neurons, astrocytes, and vascular cells, has become the focus of much discussion in the last two decades and emerging literature now suggests an association between neurovascular dysfunction and neurological disorders. In this review, we synthesize the known and suspected contributions of astrocytes to neurovascular dysfunction in disease. Throughout the brain, astrocytes are centrally positioned to dynamically mediate interactions between neurons and the cerebral vasculature, and play key roles in blood-brain barrier maintenance and neurovascular coupling. It is increasingly apparent that the changes in astrocytes in response to a variety of insults to brain tissue -collectively referred to as "reactive astrogliosis" - are not just an epiphenomenon restricted to morphological alterations, but comprise functional changes in astrocytes that contribute to the phenotype of neurological diseases with both beneficial and detrimental effects. In the context of the neurovascular unit, astrocyte dysfunction accompanies, and may contribute to, blood-brain barrier impairment and neurovascular dysregulation, highlighting the need to determine the exact nature of the relationship between astrocyte dysfunction and neurovascular impairments. Targeting astrocytes may represent a new strategy in combinatorial therapeutics for preventing the mismatch of energy supply and demand that often accompanies neurological disorders.

Combined iron oxide nanoparticle ferumoxytol and gadolinium contrast enhanced MRI define glioblastoma pseudoprogression.

BACKGROUND: Noninvasively differentiating therapy-induced pseudoprogression from recurrent disease in patients with glioblastoma is prospectively difficult due to the current lack of a biologically specific imaging metric. Ferumoxytol iron oxide nanoparticle MRI contrast characterizes innate immunity mediated neuroinflammation; therefore, we hypothesized that combined ferumoxytol and gadolinium enhanced MRI could serve as a biomarker of glioblastoma pseudoprogression. METHODS: In this institutional review board-approved, retrospective study, we analyzed ferumoxytol and gadolinium contrast enhanced T1-weighted 3T MRI in 45 patients with glioblastoma over multiple clinical timepoints. Isocitrate dehydrogenase 1 (IDH-1) mutational status was characterized by exome sequencing. Sum of products diameter measurements were calculated according to Response Assessment in Neuro-Oncology criteria from both gadolinium and ferumoxytol enhanced sequences. Enhancement mismatch was calculated as the natural log of the ferumoxytol to gadolinium sum of products diameter ratio. Analysis of variance and Student's t-test assessed differences in mismatch ratios. P-value <0.05 indicated statistical significance. RESULTS: With the development of pseudoprogression we observed a significantly elevated mismatch ratio compared with disease recurrence (P < 0.01) within IDH-1 wild type patients. Patients with IDH-1 mutation demonstrated significantly reduced mismatch ratio with the development of pseudoprogression compared with disease recurrence (P < 0.01). Receiver operator curve analysis demonstrated 100% sensitivity and specificity for the use of mismatch ratios as a diagnostic biomarker of pseudoprogression. CONCLUSION: Our study suggests that ferumoxytol to gadolinium contrast mismatch ratios are an MRI biomarker for the diagnosis of pseudoprogression in patients with glioblastoma. This may be due to the unique characterization of therapy-induced neuroinflammation.

Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.

Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool. Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in patients with impaired renal function. Other attractive imaging features of i.v. ferumoxytol include a prolonged blood pool phase and delayed intracellular uptake. With its unique pharmacologic, metabolic, and imaging properties, ferumoxytol may play a crucial role in future magnetic resonance imaging of the central nervous system, various organs outside the central nervous system, and the cardiovascular system. Preclinical and clinical studies have demonstrated the overall safety and effectiveness of this novel contrast agent, with rarely occurring anaphylactoid reactions. The purpose of this review is to describe the general and organ-specific properties of ferumoxytol, as well as the advantages and potential pitfalls associated with its use in magnetic resonance imaging. To more fully demonstrate the applications of ferumoxytol throughout the body, an imaging atlas was created and is available online as supplementary material.

The Translational Significance of the Neurovascular Unit.

The mammalian brain is supplied with blood by specialized vasculature that is structurally and functionally distinct from that of the periphery. A defining feature of this vasculature is a physical blood-brain barrier (BBB). The BBB separates blood components from the brain microenvironment, regulating the entry and exit of ions, nutrients, macromolecules, and energy metabolites. Over the last two decades, physiological studies of cerebral blood flow dynamics have demonstrated that substantial intercellular communication occurs between cells of the vasculature and the neurons and glia that abut the vasculature. These findings suggest that the BBB does not function independently, but as a module within the greater context of a multicellular neurovascular unit (NVU) that includes neurons, astrocytes, pericytes, and microglia as well as the blood vessels themselves. Here, we describe the roles of these NVU components as well as how they act in concert to modify cerebrovascular function and permeability in health and in select diseases.

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific.

Ferumoxytol ultrasmall superparamagnetic iron oxide nanoparticles can enhance contrast between neuroinflamed and normal-appearing brain tissue when used as a contrast agent for high-sensitivity magnetic resonance imaging (MRI). Here we used an anti-dextran antibody (Dx1) that binds the nanoparticle's carboxymethyldextran coating to differentiate ferumoxytol from endogenous iron and localize it unequivocally in brain tissue. Intravenous injection of ferumoxytol into immune-competent rats that harbored human tumor xenograft-induced inflammatory brain lesions resulted in heterogeneous and lesion-specific signal enhancement on MRI scans in vivo. We used Dx1 immunolocalization and electron microscopy to identify ferumoxytol in affected tissue post-MRI. We found that ferumoxytol nanoparticles were taken up by astrocyte endfeet surrounding cerebral vessels, astrocyte processes, and CD163(+)/CD68(+) macrophages, but not by tumor cells. These results provide a biological basis for the delayed imaging changes seen with ferumoxytol and indicate that ferumoxytol-MRI can be used to assess the inflammatory component of brain lesions in the clinic.

Leading quality improvement through best practice guideline development, implementation, and measurement science / Liderando mejoras de qualidad el desarrollo, implementación, y medición de las guias de buenas práticas de enfermeria / Liderando com melhor qualidade por meio da elaboraçãp, implementação e avaliação de guias de boas práticas na enfermagem

The quest for evidence-based practice has spurred action by a number of groups worldwide to develop knowledge tools. However, the uptake of knowledge and implementation of clinical practice guidelines in any practice setting requires more than just the awareness and distribution of rigorously developed guidelines. Objective: The objective of this article is to share successful implementation strategies developed by the Best Practice Guideline Program of the Registered Nurses’ Association of Ontario (RNAO), that ensure practitioners are fully aware of the best available knowledge and have adequate supports to translate clinical practice guideline recommendations into their day to day practice. Topics: Details of RNAO’s seven stage process of sound guideline development are provided and RNAO’s Best Practice Spotlight Organization Designation is highlighted as a top implementation strategy that enables organizations to partner with RNAO to implement multiple RNAO Best Practice Guidelines using a systematic planned approach and full participation of staff, with a focus on quality improvement and evaluation. The BPSO Designation is informed by implementation science and is rapidly gaining international acclaim for its effectiveness in creating high levels of nurse and other health provider engagement in quality care, evidence-based practice cultures, and improved health outcomes. Conclusions: Through its leading work in rigorous guideline development, implementation and evaluation, RNAO is successfully transforming nursing practice thorough knowledge on a global scale. (au)

La busqueda de prácticas basadas en la evidencia ha estimulado acciones por parte de un número de grupos a nivel mundial para desarrollar herramientas de conocimiento. Sin embargo, la absorción de conocimiento y la implementación de guias de practica clinica en cualquier ambiente clínico requieren más que la concientización y distribución de guias desarrolladas rigurosamente. Objetivo: El objetivo de este artículo es compartir la implementación de estrategias exitosas desarrolladas por el Programa de Guas de Buenas Practicas en Enfermeria de la Asociación de Enfermeras Profesionales de Ontario (RNAO, por sus siglas en ingles), la cual asegura que sus practicantes estén completamente consientes del mejor conocimiento disponible y que tengan el adecuado soporte para transferir las recomendaciones de guías de buenas prácticas clínicas a su práctica diaria. Temas de reflexión: Los detalles del proceso de siete etapas de la RNAO de desarrollo de la guía y el Programa de Directrices sobre las Mejores Prácticas de la RNAO son proporcionadas y resaltadas como estrategias de implementación que permite a las organizaciones asociarse con la RNAO para implementar múltiples guías de buenas prácticas usando un método sistemático planeado y una activa participación del personal, con énfasis en mejoras de calidad y evaluación. El Programa de Directrices sobre las Mejores Prácticas es informado por la ciencia de implementación y esta rápidamente ganando aclamación internacional por su eficiencia en crear altos niveles de cuidado de enfermeria y calidad en el cuidado que las instituciones sanitarias ofrecen, así como mejoramiento y mejores resultados en las practicas basadas en la evidencia. Conclusiones: A través de su labor de liderazgo en el desarrollo, la implementación y la evaluación rigurosa de las guías, la RNAO esta exitosamente transformando las prácticas de enfermería mediante el conocimiento a escala mundial.

O movimento de praticas baseadas na evidência, associado à enfermagem, tem estimulado ações em nível mundial para desenvolver ferramentas de conhecimento. Contudo, assimilar o conhecimento e implementar as diretrizes na pratica clيnica em qualquer ambiente clيnico requer mais do que conscientização e distribuição de guias de orientação desenvolvidas com rigor. Objetivo: O objetivo deste artigo é partilhar a implementação de estratégias bem-sucedidas desenvolvidas pelo Programa de Guias para a Boa Pratica na Enfermagem, da Associação de Enfermeiras de Ontario, (Canada) (RNAO, segundo sua sigla em Inglês), que assegura aos praticantes maior consciência sobre os melhores conhecimentos disponíveis fazendo-os realidade em sua pratica cotidiana, jل que as guias ou manuais de boas praticas baseadas em evidências constituem uma abordagem que possibilita melhorias da qualidade da assistência à saúde. Tَpicos: Os detalhes do processo das sete etapas do desenvolvimento RNAO de Orientação e Diretrizes do Programa de Melhores Praticas RNAO são oferecidas e destacadas como estratégias de implementação que permitem às organizações associadas com RNAO implementar diversas guias ou manuais de boas praticas através de um planejamento sistemático e da participação ativa, com ênfase na avaliação e melhoria da qualidade e da assistência à saْde permanentemente. O Programa das Diretrizes de Melhores Praticas é informado pela ciência da implementação e esta ganhando rápido reconhecimento internacional pela sua eficiência na criação de alto nível nos cuidados da enfermagem e da qualidade nos cuidados que as instituições de saúde oferecem, igualmente pela sua melhoria continua e aprimoramento dos resultados das praticas baseadas em evidências. Conclusões: através do seu protagonismo e liderança no desenvolvimento, implementação e avaliação rigorosa das guias, o RNAO esta transformando exitosamente a pratica da enfermagem, através do seu conhecimento e divulgação mundial. (au)

Spreading and sustaining best practices for home care of older adults: a grounded theory study.

BACKGROUND: Improving health care quality requires effective and timely spread of innovations that support evidence-based practices. However, there is limited rigorous research on the process of spread, factors influencing spread, and models of spread. It is particularly important to study spread within the home care sector given the aging of the population, expansion of home care services internationally, the high proportion of older adult users of home care services, and the vulnerability of this group who are frail and live with multiple chronic conditions. The purpose of this study was to understand how best practices related to older adults are spread within home care organizations. METHODS: Four home care organizations in Ontario, Canada that had implemented best practices related to older adults (falls prevention, pain management, management of venous leg ulcers) participated. Using a qualitative grounded theory design, interviews were conducted with frontline providers, managers, and directors at baseline (n = 44) and 1 year later (n = 40). Open, axial, and selective coding and constant comparison analysis were used. RESULTS: A model of the process of spread of best practices within home care organizations was developed. The phases of spread included (1) committing to change, (2) implementing on a small scale, (3) adapting locally, (4) spreading internally to multiple users and sites, and (5) disseminating externally. Factors that facilitated progression through these phases were (1) leading with passion and commitment, (2) sustaining strategies, and (3) seeing the benefits. Project leads, champions, managers, and steering committees played vital roles in leading the spread process. Strategies such as educating/coaching and evaluating and feedback were key to sustaining the change. Spread occurred within the home care context of high staff and manager turnover and time and resource constraints. CONCLUSIONS: Spread of best practices is optimized through the application of the phases of spread, allocation of resources to support spread, and implementing strategies for ongoing sustainability that address potential barriers. Further research will help to understand how best practices are spread externally to other organizations.

Effect of Concomitant 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitor Therapy on Creatine Phosphokinase Levels and Mortality Among Patients Receiving Daptomycin: Retrospective Cohort Study.

INTRODUCTION: The prescribing information for daptomycin recommends discontinuing statin therapy during receipt of daptomycin. The literature supporting this recommendation is sparse. The objectives of this study were to examine the impact of 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) on creatine phosphokinase (CPK) elevations and mortality among patients receiving daptomycin therapy. METHODS: A retrospective cohort study was performed among daptomycin recipients in the Upstate New York Veterans' Healthcare Administration from September 15, 2003 to July 1, 2013. Inclusion criteria were: (1) daptomycin for ≥48 h, (2) availability of baseline CPK value and (3) >1 CPK level measurement taken while on therapy. The following were extracted from medical records: demographics, comorbidities, laboratory data, medication history (daptomycin, statins and concomitant drugs known to increase CPK), Acute Physiology and Chronic Health Evaluation (APACHE)-II score and vital status at 30 days. The exposure of interest was use of statins. The primary outcome was CPK elevation defined as a CPK value ≥3 times the upper limit of normal (ULN) if baseline CPK was normal, and ≥5 times ULN if baseline CPK was elevated. The secondary outcome was death within 30 days of commencing daptomycin. RESULTS: A total of 233 patients were included in this analysis. Among these patients, 53 received concomitant statin therapy. Most baseline clinical characteristics were similar between statin recipients and non-recipients. Five (2.1%) patients experienced a CPK elevation; 3/53 (5.7%) were statin recipients and 2/180 (1.1%) received daptomycin alone (p = 0.08). All patients with CPK elevations had normal baseline CPK values. No effect modification was observed by use of other concomitant medications known to increase CPK values. Death was observed more frequently among statin non-recipients (17.2%) than recipients (9.4%). CONCLUSIONS: Among patients receiving daptomycin, no significant difference was observed in frequency of CPK elevation between statin recipients and non-recipients.

Utilizing quality improvement methods to prevent falls and injury from falls: enhancing resident safety in long-term care.

INTRODUCTION: Internationally, the growing evidence related to preventable adverse events within healthcare settings has resulted in the creation of numerous patient safety and quality improvement initiatives. In Canada, Safer Healthcare Now!, a national patient safety initiative of the Canadian Patient Safety Institute, and the Registered Nurses' Association of Ontario, the professional association representing registered nurses in Ontario, have partnered to combine quality improvement expertise with evidence-based practice expertise to accelerate improvement in the area of falls prevention and injury reduction. The synergistic relationship between Safer Healthcare Now! and the Registered Nurses' Association of Ontario has resulted in the evolution of the Safer Healthcare Now! national Falls Prevention intervention. The ultimate goal of the Falls Prevention intervention is to improve care by translating "what we know" into "what we do," by supporting quality improvement teams to make changes at the local level to enhance the patient experience. METHOD: This article provides an overview of Safer Healthcare Now! as a national patient safety initiative, and highlights the results of a National Collaborative on Falls Prevention as a knowledge translation strategy utilized within the long-term care setting. A description of expanding supports for knowledge translation will also be provided.

Process for developing evidence-informed practice recommendations: venous leg ulcer example.

PURPOSE: To provide the wound care practitioner with an overview of the search process for venous leg ulcer clinical practice guidelines and appraisal of their quality applying the Appraisal of Guideline Research and Evaluation (AGREE) Instrument. TARGET AUDIENCE: This continuing education activity is intended for physicians and nurses with an interest in skin and wound care. OBJECTIVES: After reading this article and taking this test, the reader should be able to: 1. Describe the process used to identify and review current wound care guidelines. 2. Describe how the AGREE Instrument evaluates the methodological quality of practice guidelines.

Development of an evaluation tool for a clinical practice guideline on nursing assessment and device selection for vascular access.

This study developed and tested a chart audit tool to assess the implementation of evidence-based recommendations for vascular access nursing assessment and device selection. Chart audits of 71 patients were conducted in a home healthcare agency and a community hospital prior to guideline implementation. Observations of initial infusion therapy and chart audit documentation of 31 patients were also compared. Results from observations indicated that nurses provided care consistent with the recommendations, but findings from chart audits indicated that assessment and decisionmaking were poorly documented. Studies that use only precomparison and postcomparison by chart audit may miss changes in nursing practice.

Research to practice: nursing stroke assessment guidelines link to clinical performance indicators.

Stroke is the fourth leading cause of death in Canada and, each year, approximately 50,000 Canadians will suffer a stroke with a range of severities from mild, short duration symptoms to significant long-term disability or death. Of these 50,000 patients, at least 20,000 are hospitalized. Earlier this year, a core set of evidence-based performance indicators were identified by a national consensus panel that may be used to determine the quality of care provided to stroke patients in hospital during the acute phase of illness. Nurses play a critical role in stroke care across the continuum and recently published stroke assessment guidelines for nurses clearly describe key approaches to assessment and/or screening of stroke survivors. Many of the nursing assessments and/or screening actions recommended in the guidelines have direct or indirect associations with the recent performance indicators. This article describes where those relationships exist and the role nurses may play in determining overall performance for acute stroke patient care delivery during the hospitalization phase of the stroke continuum of care.

Validity of methods for analyzing urinary steroid data to detect ovulation in athletes.

PURPOSE: The purpose of this study was to determine whether the accuracy of ovulation detection algorithms is compromised when applied to menstrual cycles exhibiting subclinical hormonal abnormalities, which are particularly prevalent in female athletes. METHODS: The validity of five ovulation detection algorithms was compared between 25 regularly exercising women and 15 sedentary controls. Subjects collected daily urine samples for an entire menstrual cycle for analysis of estrone-3-glucuronide (E1G), pregnanediol-3-glucuronide (PDG), and luteinizing hormone (LH). The algorithms were applied to determine their sensitivity (% of true ovulatory cycles), specificity (% of true anovulatory cycles), and the deviation from the reference day of ovulation (difference scores). RESULTS: The sensitivity was > 80% in all algorithms except Baird's E1G/PDG ratio algorithm (74%) and Kassam's PDG ratio algorithm (78%). All algorithms, except Kassam's PDG ratio algorithm (80%), were found to exhibit specificities < 70%. Baird's E1G/PDG ratio algorithm was the most accurate in estimating the day of ovulation by deviating only -0.2 +/- 0.3 d from the reference day in the exercising female cycles and -0.5 +/- 0.3 d in the controls. No statistical differences in the sensitivities of the algorithms were found between the exercising and control cycles. When comparing the deviation from the reference day of ovulation between subject groups, no statistical difference was found. CONCLUSION: The algorithms display similar validity in determining the presence and day of ovulation between subject groups, and thus may be applied to cycles exhibiting subclinical hormonal abnormalities as commonly observed in exercising women.

Client-centred care: making the ideal real.

Providing quality care in a timely manner is a key goal of the healthcare system. Who defines quality care is a pivotal question to be answered in an era of well-informed clients. The Registered Nurses Association of Ontario's (RNAO) Client-Centred Care Best Practice Guideline puts patients where they belong--at the centre of care. This guideline recommends that nurses embrace as foundational to their practice a set of values and beliefs. These include: respect, human dignity and the belief that clients are the experts regarding their own lives. Clients must be provided the opportunity to lead their care as much as they choose. Moreover, the guideline recommends that nurses advocate for their clients' goals within the entire healthcare team. Recommendations regarding the organization of nursing care emphasize continuity and consistency of care and caregiver as paramount to providing timely and responsive client-centred-care. This article presents the rationale for the development of a CCC-BPG and highlights its key recommendations. It also discusses the responsibilities of healthcare practitioners and administrators in working together to ensure that these recommendations are incorporated into every aspect of client care and services.