ABSTRACT
We report a case of cat-scratch disease neuroretinitis. A 26-year-old man was referred for severe right visual loss. Posterior segment examination showed a papilledema with macular edema. Bartonella henselae immunoglobulin G testing was positive. Four weeks of antibiotic therapy combining oral ciprofloxacin and doxycycline led to progressive resolution of the neuroretinitis and improvement in visual acuity. This report reminds that B. henselae infection can be the cause of neuroretinitis. Its prognosis can be improved by early treatment.
Subject(s)
Bartonella henselae , Cat-Scratch Disease/complications , Cat-Scratch Disease/diagnosis , Retinitis/diagnosis , Retinitis/microbiology , Adult , Animals , Anti-Bacterial Agents/therapeutic use , Bartonella henselae/immunology , Cat-Scratch Disease/drug therapy , Cats , Ciprofloxacin/therapeutic use , Doxycycline/therapeutic use , Drug Therapy, Combination , Humans , Male , Retinitis/drug therapy , Treatment OutcomeABSTRACT
Leber congenital amaurosis (LCA) is a the earliest and most severe form of retinal dystrophy responsible for congenital blindness. LCA has genetic heterogeneity and the study of this disease is elucidating the genetics and molecular interactions involved in the development of the retina. To date, 11 LCA genes have been mapped, ten of which have been identified. The CEP290 gene has been shown to account for Joubert and Senior-Loken syndromes and to be a frequent cause of nonsyndromic LCA. We report here the first Arab patient, born to consanguineous parents, with Leber congenital amaurosis attributable to mutation of the CEP290 gene.
