ABSTRACT
A case of sino-pulmonary infection with skull base osteomyelitis due to XDR-Pseudomonas aeruginosa in renal transplant recipient was successfully treated with investigational antibiotic, cefepime/zidebactam (WCK 5222). This case highlights challenges in managing XDR-pseudomonal infection where source control was infeasible, antibiotic options were extremely limited and individualized dose adjustments were needed.
Subject(s)
Coordination Complexes/chemistry , Macromolecular Substances/chemistry , Organometallic Compounds/chemistry , Ruthenium/chemistry , Animals , Artemia/drug effects , Artemia/genetics , Bacillus subtilis/drug effects , Bacillus subtilis/pathogenicity , Coordination Complexes/chemical synthesis , Coordination Complexes/pharmacology , Escherichia coli/drug effects , Escherichia coli/pathogenicity , Humans , Macromolecular Substances/chemical synthesis , Molecular Structure , Organometallic Compounds/chemical synthesis , Organometallic Compounds/pharmacology , Plasmodium falciparum/drug effects , Plasmodium falciparum/pathogenicity , Ruthenium/pharmacology , Staphylococcus aureus/drug effects , Staphylococcus aureus/pathogenicityABSTRACT
The mononuclear copper(II) complexes with P, O-donor ligand and different fluoroquinolones have been synthesized and characterized by elemental analysis, electronic spectra, TGA, EPR, FT-IR and LC-MS spectroscopy. An antimicrobial efficiency of the complexes has been tested against five different microorganisms in terms of minimum inhibitory concentration (MIC) and displays very good antimicrobial activity. The binding strength and binding mode of the complexes with Herring Sperm DNA (HS DNA) have been investigated by absorption titration and viscosity measurement studies. The studies suggest the classical intercalative mode of DNA binding. Gel electrophoresis assay determines the ability of the complexes to cleave the supercoiled form of pUC19 DNA. Synthesized complexes have been tested for their SOD mimic activity using nonenzymatic NBT/NADH/PMS system and found to have good antioxidant activity. All the complexes show good cytotoxic and in vitro antimalarial activities.
