Demographic and Clinical Characteristics of Mpox in Persons Who Had Previously Received 1 Dose of JYNNEOS Vaccine and in Unvaccinated Persons - 29 U.S. Jurisdictions, May 22-September 3, 2022.

As of November 14, 2022, monkeypox (mpox) cases had been reported from more than 110 countries, including 29,133 cases in the United States.* Among U.S. cases to date, 95% have occurred among males (1). After the first confirmed U.S. mpox case on May 17, 2022, limited supplies of JYNNEOS vaccine (Modified Vaccinia Ankara vaccine, Bavarian Nordic) were made available to jurisdictions for persons exposed to mpox. JYNNEOS vaccine was approved by the Food and Drug Administration (FDA) in 2019 as a 2-dose series (0.5 mL per dose, administered subcutaneously) to prevent smallpox and mpox disease.† On August 9, 2022, FDA issued an emergency use authorization to allow administration of JYNNEOS vaccine by intradermal injection (0.1 mL per dose) (2). A previous report on U.S. mpox cases during July 31-September 3, 2022, suggested that 1 dose of vaccine offers some protection against mpox (3). This report describes demographic and clinical characteristics of cases occurring ≥14 days after receipt of 1 dose of JYNNEOS vaccine and compares them with characteristics of cases among unvaccinated persons with mpox and with the vaccine-eligible vaccinated population in participating jurisdictions. During May 22-September 3, 2022, among 14,504 mpox cases reported from 29 participating U.S. jurisdictions,§ 6,605 (45.5%) had available vaccination information and were included in the analysis. Among included cases, 276 (4.2%) were among persons who had received 1 dose of vaccine ≥14 days before illness onset. Mpox cases that occurred in these vaccinated persons were associated with lower percentage of hospitalization (2.1% versus 7.5%), fever, headache, malaise, myalgia, and chills, compared with cases in unvaccinated persons. Although 1 dose of JYNNEOS vaccine offers some protection from disease, mpox infection can occur after receipt of 1 dose, and the duration of protection conferred by 1 dose is unknown. Providers and public health officials should therefore encourage persons at risk for acquiring mpox to complete the 2-dose vaccination series and provide guidance and education regarding nonvaccine-related prevention strategies (4).

HIV and Sexually Transmitted Infections Among Persons with Monkeypox - Eight U.S. Jurisdictions, May 17-July 22, 2022.

High prevalences of HIV and other sexually transmitted infections (STIs) have been reported in the current global monkeypox outbreak, which has affected primarily gay, bisexual, and other men who have sex with men (MSM) (1-5). In previous monkeypox outbreaks in Nigeria, concurrent HIV infection was associated with poor monkeypox clinical outcomes (6,7). Monkeypox, HIV, and STI surveillance data from eight U.S. jurisdictions* were matched and analyzed to examine HIV and STI diagnoses among persons with monkeypox and assess differences in monkeypox clinical features according to HIV infection status. Among 1,969 persons with monkeypox during May 17-July 22, 2022, HIV prevalence was 38%, and 41% had received a diagnosis of one or more other reportable STIs in the preceding year. Among persons with monkeypox and diagnosed HIV infection, 94% had received HIV care in the preceding year, and 82% had an HIV viral load of <200 copies/mL, indicating HIV viral suppression. Compared with persons without HIV infection, a higher proportion of persons with HIV infection were hospitalized (8% versus 3%). Persons with HIV infection or STIs are disproportionately represented among persons with monkeypox. It is important that public health officials leverage systems for delivering HIV and STI care and prevention to reduce monkeypox incidence in this population. Consideration should be given to prioritizing persons with HIV infection and STIs for vaccination against monkeypox. HIV and STI screening and other recommended preventive care should be routinely offered to persons evaluated for monkeypox, with linkage to HIV care or HIV preexposure prophylaxis (PrEP) as appropriate.

Factores psicosociales y síndrome de burnout en personal de enfermería de una unidad de tercer nivel de atención a la salud / Psychosocial factors and burnout syndrome in nurses of a unit of tertiary health care

El OBJETIVO fue determinar la relación entre los factores psicosociales laborables y el síndrome de Burnout en personal de enfermería de una unidad de tercer nivel de atención a la salud. MATERIAL Y MÉTODOS: Se trata de un estudio observacional, transversal y analítico en personal de enfermería de una unidad de tercer nivel de atención a la salud. Los datos se captaron con el instrumento de factores psicosociales de Silva y el MBI. Se analizaron con el apoyo del SPSS. RESULTADOS: Participaron 163 personas de 21 servicios de la unidad de atención; 88% eran mujeres, 41,4% laboraba en el turno matutino y 47,5% perciben la presencia de factores psicosociales negativos en su área de trabajo, siendo lo más frecuente las exigencias laborales, remuneración del rendimiento y condiciones inadecuadas en su lugar de trabajo. En cuanto al Burnout, 33,3% presentaba agotamiento emocional, 50,8% baja realización personal y 17,9% despersonalización. El agotamiento emocional se relacionó (p < a 0,05) con seis de las ocho áreas de los factores psicosociales evaluados CONCLUSIÓN: Se confirmó la relación entre los factores psicosociales laborales y el síndrome de Burnout.

The OBJECTIVE was to determine the relationship between psychosocial factors and working burnout syndrome in nursing staff of a unit of tertiary health care. MATERIAL Y METHODS: It is an observational, cross-sectional analytical study in nursing staff of a unit of tertiary health care. The data were collected with the instrument of psychosocial factors Silva and MBI. It was analyzed with the support of SPSS. RESULTS: A total of 163 people from 21 services care unit; 88% were women, 41,4% worked in the morning shift and 47,5% perceive the presence of negative psychosocial factors in their work area, where work demands are the most frequent, performance reward and inadequate conditions in work place. Regarding the Burnout, 33,3% had emotional exhaustion, 50,8% reduced personal accomplishment and depersonalization 17,9%. Emotional exhaustion was associated (p <0,05) with six of the eight areas of psychosocial factors evaluated CONCLUSION: the relationship between psychosocial factors and confirmed Burnout syndrome.