Subject(s)
Allergens/immunology , Desensitization, Immunologic , Food Hypersensitivity/immunology , Food Hypersensitivity/therapy , Gadiformes/immunology , Administration, Oral , Adolescent , Allergens/administration & dosage , Animals , Child , Child, Preschool , Desensitization, Immunologic/methods , Food Hypersensitivity/diagnosis , Humans , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Child, Preschool , Child , Adolescent , Allergens/immunology , Desensitization, Immunologic , Food Hypersensitivity/immunology , Food Hypersensitivity/therapy , Gadiformes/immunology , Administration, Oral , Allergens/administration & dosage , Desensitization, Immunologic/methods , Treatment Outcome , Prospective StudiesSubject(s)
Anti-Allergic Agents/therapeutic use , Desensitization, Immunologic/methods , Egg Hypersensitivity/therapy , Milk Hypersensitivity/therapy , Omalizumab/therapeutic use , Allergens/immunology , Animals , Cattle , Child , Child, Preschool , Combined Modality Therapy , Egg Hypersensitivity/immunology , Egg Proteins/immunology , Female , Humans , Immunoglobulin E/blood , Male , Milk Hypersensitivity/immunology , Milk Proteins/immunology , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Male , Child , Anaphylaxis/complications , Anaphylaxis/diagnosis , Food Hypersensitivity/complications , Food Hypersensitivity/genetics , Cocos/adverse effects , Shellfish/classification , Shellfish/toxicity , Skin Tests/methods , Anaphylaxis/classification , Anaphylaxis/metabolism , Food Hypersensitivity/metabolism , Cocos/toxicity , Shellfish/adverse effects , Skin Tests/instrumentationABSTRACT
Perioperative anaphylactic reactions are immediate, hypersensitive reactions that are potentially life-threatening resulting from a sudden release of mediators from mast cells and basophiles, due to either immune (IgE or non-IgE mediated) or non-immune mechanisms. The most frequent causing agents are neuromuscular blocking agents (NMBAs), latex and antibiotics, with latex being the first cause in paediatrics. With regard to perioperative anaphylactic reactions, the usual early signs and symptoms of an anaphylactic reaction could be overlooked or erroneously interpreted and non-severe anaphylaxis could go undetected, with a risk of more severe reactions in the future. Using the data registered on the anaesthesia sheet, it is essential to establish a chronological relationship between drugs and/or substances administered and the reaction observed. An elevated level of tryptase confirms an anaphylactic reaction, but this does not usually increase in the absence of compromised circulation. An allergy study should be carried out preferably between 4 and 6 weeks after the reaction, using a combination of specific IgE, skin and controlled exposure tests (if indicated). Test sensitivity is good for NMBAs, latex, antibiotics, chlorhexidine, gelatine and povidone, and poor for barbiturates, opiates (these can give false positives since they are histamine releasers) and benzodiazepines. Special preventive measures should be taken, especially in the case of latex. We present the maximum concentrations recommended for skin tests, the recommended dosage to treat anaphylactic reactions in paediatrics and a procedure algorithm for the allergological study of these reactions.
Subject(s)
Anaphylaxis/prevention & control , Drug Hypersensitivity/diagnosis , Intraoperative Complications/prevention & control , Latex Hypersensitivity/diagnosis , Surgical Procedures, Operative , Algorithms , Anaphylaxis/etiology , Animals , Child , Drug Hypersensitivity/complications , Humans , Latex Hypersensitivity/complications , Perioperative Care , Skin TestsSubject(s)
Anaphylaxis/diagnosis , Cocos/immunology , Hypersensitivity/diagnosis , Immunotherapy , Respiratory Insufficiency/diagnosis , Adolescent , Anaphylaxis/immunology , Antigens, Plant/immunology , Cross Reactions , Feeding Behavior , Fruit , Humans , Hypersensitivity/immunology , Hypersensitivity/therapy , Immunoglobulin E/blood , Plant Extracts , Respiratory Insufficiency/immunology , Skin TestsSubject(s)
Anaphylaxis/diagnosis , Anaphylaxis/etiology , Excipients/adverse effects , Povidone/adverse effects , Albuterol/therapeutic use , Anaphylaxis/drug therapy , Child, Preschool , Histamine H1 Antagonists/therapeutic use , Humans , Hydroxyzine/therapeutic use , Male , Pregnenediones/therapeutic use , Skin TestsABSTRACT
OBJECTIVE: To study the incidence of IgE-mediated allergy to cow's milk proteins during the first year of life. METHODS: A multicenter, prospective study of newborns selected from different health centers was performed. The newborn infants were followed-up during the first year of life. Newborns with suspected adverse reaction to cow's milk were sent to the referral hospital for diagnostic study. This study was based on clinical history, skin tests (skin prick test) and on determination of specific IgE in serum (Pharmacia CAP system) against cow's milk and its protein fractions. Diagnosis was confirmed by open challenge. RESULTS: A total of 1,663 newborns were followed-up during the first year of life. Adverse reaction was suspected in 56 infants (3.3%). Allergy to cow's milk proteins was confirmed in 6 infants (0.36 %). Eighty-three percent of (5/6) children with cow's milk allergy had first-degree relatives with atopic disease compared with 19 % of children (329/1657) without cow's milk allergy. Among the entire sample, 26 infants had first-degree relatives with atopic disease and one of these infants (3.8%) developed cow milk allergy. The six children with cow's milk allergy were exclusively breast-fed, and clinical reaction developed within 1 week of the introduction of artificial feeding. CONCLUSION: The incidence of IgE-mediated allergy to cow's milk was 0.36 %. In infants with two first-degree family members with atopic disease, the probability of developing allergy to cow's milk proteins during the first year of life was 3.8%.
Subject(s)
Immunoglobulin E/immunology , Milk Hypersensitivity/epidemiology , Milk Hypersensitivity/immunology , Milk Proteins/immunology , Animals , Cattle , Female , Humans , Incidence , Infant , Male , Prospective StudiesABSTRACT
Objetivo: Estudiar la incidencia de alergia mediada por IgE frente a la proteína de la leche de vaca en el primer año de vida. Métodos Se realizó un estudio multicéntrico, prospectivo, en el que se siguieron recién nacidos durante el primer año de vida seleccionados de diferentes centros de salud. Ante la sospecha de reacción adversa frente a la leche de vaca se envía al Hospital de referencia para estudio diagnóstico. Dicho estudio se basó en la historia clínica compatible, pruebas cutáneas (prick test) y determinación de IgE sérica específica (Pharmacia CAP system) frente a la leche de vaca y sus fracciones proteicas. La confirmación se realizó mediante provocación abierta. Resultados: Se han seguido durante el primer año de vida 1.663 recién nacidos. En 56 niños (3,3%) hubo sospecha de reacción adversa, que se confirmó en 6 niños (0,36%) un cuadro de alergia a la proteína de la leche de vaca (APLV). El 83% (5/6) de los niños con APLV tenían antecedentes familiares de primer grado de enfermedad atópica frente al 19% (329/1.657) del grupo de niños sin APLV. Del total de la muestra, 26 recién nacidos presentaba dos antecedentes familiares de primer grado de enfermedad atópica y uno de ellos desarrolló un cuadro de APLV (3,8%). Los 6 niños con APLV fueron alimentados de forma exclusiva con lactancia materna y la reacción clínica se produjo dentro de la primera semana de introducir la lactancia artificial. Conclusión: La incidencia de alergia mediada por IgE frente a la proteína de la leche de vaca es del 0,36%. La probabilidad de un recién nacido de desarrollar un cuadro de APLV en el primer año de vida cuando existen dos antecedentes familiares de primer grado de enfermedad atópica es del 3,8% (AU)
Subject(s)
Animals , Cattle , Male , Infant , Female , Humans , Milk Hypersensitivity , Incidence , Milk Proteins , Prospective Studies , Immunoglobulin EABSTRACT
To compare the results between asthmatics with different etiology, to study the bronchial reactivity in nonasthmatics, and verify if 8 mg/ml is a good limit of differentiation between asthmatics and healthy ones, a methacholine test was performed in fourty children distributed in four groups: group I (atopic asthmatics); group II (nonatopic asthmatics); group III (nonsymptomatic brothers of asthmatics) and group IV (healthy controls without IV. The means values of PC20 FEV1 were: Group I, 0.42; familiar antecedents of asthma). In groups I and II were all positives, in group III two cases (20%) and none in group II, 0.64; group III, 7.37, and group IV, 16.4 mg/ml. It is verified pathogenic meaning of the bronchial hyperreactivity in the asthma independently of its etiology, and the satisfactory differentiation between asthmatics and healthy ones with 8 mg/ml as limit of positivity. It is suggested the realization of extensive studies in brothers of asthmatics to determine the usefulness of the test as screening in such children.
