Subject(s)
Dapsone , Folliculitis , Alopecia , Dapsone/therapeutic use , Folliculitis/drug therapy , Humans , Retrospective StudiesABSTRACT
BACKGROUND: Folliculitis decalvans (FD) is a rare neutrophilic cicatricial alopecia that poses a therapeutic challenge. OBJECTIVES: To describe the therapeutic response in a large number of cases of FD with long-term follow-up and analyze potential prognostic factors associated with severity of form and with a better therapeutic response. METHODS: This multicenter prospective study included patients with FD who had a minimum of 5 years of follow-up. Severity was assessed by the maximum diameter of the cicatricial area. Therapeutic response was evaluated according to stabilization of the size of the cicatricial areas and the improvement in clinical symptoms. RESULTS: A total of 60 patients (37 men [61.7%] and 23 women [38.3%]) with a mean age of 40 years were included. Earlier age of onset (P = .01) was statistically associated with severity of form. Treatment with rifampicin and clindamycin, tetracyclines, and intralesional steroids was the most effective. No statistically significant prognostic factors predicting a better therapeutic response were found. LIMITATIONS: Because FD is a rare disease, the main limitation was the sample size. CONCLUSIONS: An earlier age of onset was associated with the severe form of the disease. The proposed specific therapeutic protocol can be a very useful tool in clinical dermatologic practice.
Subject(s)
Alopecia/pathology , Folliculitis/drug therapy , Folliculitis/pathology , Scalp Dermatoses/drug therapy , Scalp Dermatoses/pathology , Adrenal Cortex Hormones/therapeutic use , Alopecia/drug therapy , Alopecia/etiology , Anti-Bacterial Agents/therapeutic use , Cicatrix/drug therapy , Cicatrix/pathology , Cohort Studies , Combined Modality Therapy , Female , Folliculitis/complications , Follow-Up Studies , Humans , Isotretinoin/therapeutic use , Male , Minoxidil/therapeutic use , Multivariate Analysis , Photochemotherapy/methods , Retrospective Studies , Risk Assessment , Scalp Dermatoses/complications , Spain , Time Factors , Treatment OutcomeSubject(s)
Melanoma/diagnosis , Skin Neoplasms/diagnosis , Biopsy , DNA Mutational Analysis , Female , Humans , Liver Neoplasms/genetics , Liver Neoplasms/pathology , Liver Neoplasms/secondary , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Lymphatic Metastasis/genetics , Lymphatic Metastasis/pathology , Melanoma/genetics , Melanoma/pathology , Middle Aged , Neoplasm Metastasis , Positron Emission Tomography Computed Tomography , Proto-Oncogene Proteins B-raf/genetics , Scapula , Skin/pathology , Skin Neoplasms/genetics , Skin Neoplasms/pathology , Melanoma, Cutaneous MalignantABSTRACT
Folliculitis decalvans (FD) is a primary neutrophilic scarring alopecia characterized by perifollicular papules, crusts, and pustules frequently located on the vertex. FD may affect young men and women. Since it may lead to hair loss, it can have a negative impact on patients' quality of life. Nevertheless, studies have focused on clinical, prognostic, and therapeutic aspects without considering the psychological impact of FD. In our study, we found that FD patients experienced a considerable impact on their quality of life. Interestingly, almost half of the patients considered that their alopecia was related to a poor medical care in their past. To our knowledge, this is the first description of the impact of FD on patients' quality of life, and it highlights the importance of psychological support for these patients.
Subject(s)
Immunocompromised Host , Meningococcal Infections , Anti-Bacterial Agents/administration & dosage , Cefotaxime/administration & dosage , Child, Preschool , Chronic Disease , Humans , Male , Meningococcal Infections/drug therapy , Meningococcal Infections/physiopathology , Neisseria meningitidis, Serogroup B/isolation & purificationSubject(s)
Adrenal Cortex Hormones/administration & dosage , Alopecia/drug therapy , Dexamethasone/administration & dosage , Hair/growth & development , Administration, Oral , Adrenal Cortex Hormones/adverse effects , Adult , Alopecia/diagnosis , Cohort Studies , Dexamethasone/adverse effects , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Therapy, Combination , Female , Follow-Up Studies , Hair/drug effects , Humans , Male , Middle Aged , Prospective Studies , Pulse Therapy, Drug , Treatment Outcome , Young AdultSubject(s)
Alopecia/drug therapy , Azathioprine/administration & dosage , Hair/growth & development , Quality of Life , Administration, Oral , Adult , Alopecia/diagnosis , Alopecia/psychology , Cohort Studies , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Follow-Up Studies , Hair/drug effects , Humans , Male , Middle Aged , Prospective Studies , Time Factors , Treatment Outcome , Young AdultSubject(s)
Eyebrows/drug effects , Eyelashes/drug effects , Hypertrichosis/chemically induced , Hypertrichosis/diagnosis , Quinazolines/adverse effects , Afatinib , Aged , ErbB Receptors/antagonists & inhibitors , Eyebrows/pathology , Eyelashes/pathology , Female , Humans , Radiation-Sensitizing Agents/adverse effectsSubject(s)
Gastrointestinal Agents/adverse effects , Infliximab/adverse effects , Skin Diseases, Vascular/chemically induced , Thromboembolism/chemically induced , Colitis, Ulcerative/drug therapy , Drug Eruptions/etiology , Humans , Male , Middle Aged , Toes , Tumor Necrosis Factor-alpha/antagonists & inhibitorsABSTRACT
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