Experimental search for the violation of Pauli exclusion principle: VIP-2 Collaboration.

The VIolation of Pauli exclusion principle -2 experiment, or VIP-2 experiment, at the Laboratori Nazionali del Gran Sasso searches for X-rays from copper atomic transitions that are prohibited by the Pauli exclusion principle. Candidate direct violation events come from the transition of a 2p electron to the ground state that is already occupied by two electrons. From the first data taking campaign in 2016 of VIP-2 experiment, we determined a best upper limit of [Formula: see text] for the probability that such a violation exists. Significant improvement in the control of the experimental systematics was also achieved, although not explicitly reflected in the improved upper limit. By introducing a simultaneous spectral fit of the signal and background data in the analysis, we succeeded in taking into account systematic errors that could not be evaluated previously in this type of measurements.

Extremely long decay time optical cavity.

We report on the resonant Fabry Perot cavity of the PVLAS (Polarization of the Vacuum with LASer) experiment operating at λ = 1064 nm with a record decay time of 2.7 ms, a factor more than two larger than any previously reported optical resonator. This corresponds to a coherence length of 8.1 · 10(5) m. The cavity length is 3.303 m, and the resulting finesse is 770,000.

Metabolic scaling in solid tumours.

Tumour metabolism is an outstanding topic of cancer research, as it determines the growth rate and the global activity of tumours. Recently, by combining the diffusion of oxygen, nutrients, and metabolites in the extracellular environment, and the internal motions that mix live and dead cells, we derived a growth law of solid tumours which is linked to parameters at the cellular level. Here we use this growth law to obtain a metabolic scaling law for solid tumours, which is obeyed by tumours of different histotypes both in vitro and in vivo, and we display its relation with the fractal dimension of the distribution of live cells in the tumour mass. The scaling behaviour is related to measurable parameters, with potential applications in the clinical practice.

A quantitative study of growth variability of tumour cell clones in vitro.

OBJECTIVES: In this study, we quantify growth variability of tumour cell clones from a human leukaemia cell line. MATERIALS AND METHODS: We have used microplate spectrophotometry to measure growth kinetics of hundreds of individual cell clones from the Molt3 cell line. Growth rate of each clonal population has been estimated by fitting experimental data with the logistic equation. RESULTS: Growth rates were observed to vary between different clones. Up to six clones with growth rates above or below mean growth rate of the parent population were further cloned and growth rates of their offspring were measured. Distribution of growth rates of the subclones did not significantly differ from that of the parent population, thus suggesting that growth variability has an epigenetic origin. To explain observed distributions of clonal growth rates, we have developed a probabilistic model, assuming that fluctuation in the number of mitochondria through successive cell cycles is the leading cause of growth variability. For fitting purposes, we have estimated experimentally by flow cytometry the average maximum number of mitochondria in Molt3 cells. The model fits nicely observed distributions in growth rates; however, cells in which mitochondria were rendered non-functional (rho(0) cells) showed only 30% reduction in clonal growth variability with respect to normal cells. CONCLUSIONS: A tumour cell population is a dynamic ensemble of clones with highly variable growth rates. At least part of this variability is due to fluctuations in the initial number of mitochondria in daughter cells.

Experimental observation of optical rotation generated in vacuum by a magnetic field.

We report the experimental observation of a light polarization rotation in vacuum in the presence of a transverse magnetic field. Assuming that data distribution is Gaussian, the average measured rotation is (3.9 +/- 0.5) x 10(-12) rad/pass, at 5 T with 44 000 passes through a 1 m long magnet, with lambda = 1064 nm. The relevance of this result in terms of the existence of a light, neutral, spin-zero particle is discussed.

Exactly solved dynamics for an infinite-range spin system.

It is well known that the dynamical evolution of a system of N spins can be viewed as a walk along the edges of an N-dimensional hypercube. I use this correspondence in an infinite-range spin system to derive a diffusion equation for the magnetization. The diffusion equation then leads to an ordinary differential equation that describes the time evolution of the magnetization for any given initial condition, and it is used to derive both static and dynamic properties of the spin system.