[Results of Investigation of MRSA Susceptibility to Vancomycin in Clinical Units of Large Multifunctional Hospital and Recommendations on Optimization of Antibacterial Therapy of Staphylococcal Infection].

The frequency of MRSA and MRSE isolates in various units of the Voronezh Regional Hospital was investigated by the results of the local microbiological monitoring for 2014. The maximum position of MRSA was recorded in the ICU (38 to 75% of the strains). The MRSA strains were characterized by higher methicillin resistance, mainly from the cardiosurgical units (60 to 91% of the isolates). The use of the E-test for MRSA susceptibility to vancomycin allowed to estimate the validity of the use of various antibiotics active against MRSA in the treatment of inpatients and to reduce the risk of ineffective therapy.

[The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. / Deiaki aspekty membranoprotektornoï diï novoho preparatu n-3 poliienovykh kyslot pry adrenalinovomu poshkodzhenni miokarda.

We undertook this study to evaluate effects of a long-term pretreatment with a new stabilized drug preparation n-3 polyunsaturated fatty acids (PUFAs) in the development of experimental adrenalin-induced necrosis of the myocardium. It was found out that the preliminary administration of PUFAs makes for a significant reduction in the mass of the infarcted area of the myocardium. Severely manifest arrhythmias were less frequently seen in treated animals, with death rates among them being lower than in controls, and what is more, an excess activation of the biomembrane lipid peroxidation and suppression of the function of the system of antioxidant defence, occurring in necrosis of the myocardium in an experimental setting, appeared to be generally preventable. It is suggested that the ability of n-3 PUFAs to modulate the properties of the biological membranes might account for the above effects.