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Bioorg Med Chem Lett
; 21(24): 7489-95, 2011 Dec 15.
Article
in English
| MEDLINE
| ID: mdl-22047689
ABSTRACT
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.