ABSTRACT
BACKGROUND: An evaluation of the extent and mechanism of damage of the central nervous system in diabetes mellitus is of high value in current neurological research. Electrophysiological abnormalities are frequently present is completely asymatomatic diabetes mellitus (DM) patients. Limited data is available in the use of brainstem auditory evoked potential (BAEP) in DM. AIM: Is to evaluate the efficacy of BAEP as a method useful in the diagnosis of subclinical damage of the central nervous system in DM. MATERIAL AND METHOD: 67 diabetes and 32 healthy controls - age and sex matched - were chosen. The diabetes were of type I and II and more than or less than 10 years duration. The BAEP was elicited by using auditory stimulus by using Dantec Evomatic 4000 evoked potential machine. The latency of component response recored as waves I, III and V, interpeak latency (IPLs) I - III, I - V, III - V and amplitude of waves V. RESULTS: The difference was highly significant in the increased latency of waves I, III and V, interpeak latency (IPLs) I - III, I - V, III - V and amplitude of waves V of each type of diabetes as compared to control. Comparison of the type and duration of diabetes between each other showed no significant difference. CONCLUSION: BAEP recording can represent an objective, clinically useful and non invasive procedure to stress the early impairment both of the auditory nerve and of brainstem function.
Subject(s)
Central Nervous System Diseases/diagnosis , Diabetic Neuropathies/diagnosis , Evoked Potentials, Auditory, Brain Stem/physiology , Adult , Aged , Central Nervous System Diseases/etiology , Central Nervous System Diseases/physiopathology , Diabetic Neuropathies/physiopathology , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Sensitivity and SpecificityABSTRACT
BACKGROUND: Electrophysiological testing can be of value in early diagnosis of diabetic neuropathy. Limited data is available in the use of the blink reflex (BR) in diabetes mellitus (MD). AIM: is to evaluate the efficacy of BR in early diagnosis of cranial nerve neuropathy in DM. MATERIALS AND METHODS: 67 diabetes and 32 healthy controls-age and sex matched- were chosen. The diabetes were of type I and type II and of more than or less than 10 years duration. The BR was elicited by stimulation the supraorbital nerve using the Dantec Neuromatic 2000M machine. The latency of the components response recorded as R1, R2y (ipsilateral) and R2c (contralateral). A direct response was achieved by the stimulation of the facial nerve; a square wave of 200 msec. was used. RESULTS: No differences were noted when the two sides were compared in diabetic patients, while the difference was highly significant in the increased latency of R1, R2y and R2c each type of diabetes as compared to the control. Comparison of the types and duration of diabetes between each other showed no significant difference. Direct measurement of the latency response of the facial nerve gave a response in diabetics of both types and duration. CONCLUSION: the BR can be useful in the early diagnosis of diabetic neuropathy.
Subject(s)
Blinking/physiology , Diabetic Neuropathies/diagnosis , Diabetic Neuropathies/physiopathology , Adult , Aged , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 2/complications , Early Diagnosis , Female , Humans , Male , Middle Aged , Reaction TimeABSTRACT
Multiple oral and cutaneous nodular and papular reddish-blue lesions are described in the case of a 60-year-old woman. The duration of the lesions was more than 1 year, with the oral lesion preceding the skin lesions. Histopathological examination revealed malignant vascular tumour with changes consistent with angiosarcoma. Angiosarcoma is an extremely rare malignant tumour of the oral cavity, and the present case describes oral and skin lesions with a unique clinical behaviour.