ABSTRACT
A case with a complex chromosome abnormality with a t(2;2)(p23;q23) in CD30+/Ki-1+ anaplastic large cell lymphoma (ALCL) is described. This chromosome aberration has not been reported previously in neoplastic diseases and was associated with T-cell phenotype and involvement of the nasopharynx by the tumour.
Subject(s)
Chromosomes, Human, Pair 2 , Lymphoma, Large-Cell, Anaplastic/genetics , Translocation, Genetic , Aged , Humans , Karyotyping , MaleSubject(s)
Chromosome Aberrations , Chromosome Disorders , Chromosomes, Human, Pair 3 , Myeloproliferative Disorders/genetics , Spouses , Aged , Female , Humans , MaleABSTRACT
A case of essential thrombocythemia (ET) with extreme thrombocytosis in a 70-year-old male patient is described. The cytogenetic analysis revealed a pathologic clone with the following previously unreported, unusual karyotype: 46,XY,t(13;14)(q32:q32.3) and pericentric inversion of chromosome 9. The possible association of t(13;14) with the high platelet count is discussed.
Subject(s)
Chromosome Aberrations/genetics , Chromosome Inversion , Chromosomes, Human, Pair 13/genetics , Chromosomes, Human, Pair 14/genetics , Chromosomes, Human, Pair 9/genetics , Thrombocythemia, Essential/genetics , Thrombocytosis/genetics , Translocation, Genetic/genetics , Aged , Humans , Karyotyping , Male , Thrombocythemia, Essential/complications , Thrombocytosis/complicationsABSTRACT
The clinical cytogenetic findings of a patient with acute monocytic leukemia with peripheral and bone marrow basophilia are presented. The cytogenetic analysis of bone marrow cells established a pathologic clone with the following unusual karyotype: 47,XY,+X,t(2;10)(q21.1;q26.1). This chromosome abnormality has not been reported previously in leukemic diseases.