ABSTRACT
BACKGROUND: Klotho is an anti-aging protein that is predominantly secreted by the kidneys. OBJECTIVES: The aim of the study was to measure and compare the circulating Klotho levels in the serum of trained athletes and in healthy, non-athlete controls. MATERIALS AND METHODS: Thirty trained football players were enrolled and their serum Klotho levels were measured the morning after their last evening exercise training. RESULTS: The plasma free Klotho concentration was significantly higher in the athlete group (3.375 ± 1.48 ng/mL) compared to the non-athletes (1.39 ± 0.43 ng/mL) (P < 0.05). Serum levels of cholesterol, triglycerides, calcium, and phosphorus were not significantly different between the two groups. CONCLUSIONS: Regular aerobic exercise could increase plasma Klotho levels, and this could be an explanation for exercise-related anti-aging effects.