Survival analysis of time to SARS-CoV-2 PCR negativisation to optimise PCR prescription in health workers: the Henares COVID-19 healthcare workers cohort study.

OBJECTIVES: Reverse transcriptase PCR (RT-PCR) is considered the gold standard in diagnosing COVID-19. Infected healthcare workers do not go back to work until RT-PCR has demonstrated that the virus is no longer present in the upper respiratory tract. The aim of this study is to determine the most efficient time to perform RT-PCR prior to healthcare workers' reincorporation. MATERIALS AND METHODS: This is a cohort study of healthcare workers with RT-PCR-confirmed COVID-19. Data were collected using the medical charts of healthcare workers and completed with a telephone interview. Kaplan-Meier curves were used to determine the influence of several variables on the time to RT-PCR negativisation. The impact of the variables on survival was assessed using the Breslow test. A Cox regression model was developed including the associated variables. RESULTS: 159 subjects with a positive RT-PCR out of 374 workers with suspected COVID-19 were included. The median time to negativisation was 25 days from symptom onset (IQR 20-35 days). Presence of IgG, dyspnoea, cough and throat pain were associated with significant longer time to negativisation. Cox logistic regression was used to adjust for confounding variables. Only dyspnoea and cough remained in the model as significant determinants of prolonged negativisation time. Adjusted HRs were 0.68 (0.48-096) for dyspnoea and 0.61 (0.42-0.88) for dry cough. CONCLUSIONS: RT-PCR during the first 3 weeks leads to a high percentage of positive results. In the presence of respiratory symptoms, negativisation took nearly 1 week more. Those who developed antibodies needed longer time to negativisate.

Ductular cholestasis, an unusual form of intrahepatic cholestasis, associated with cardiogenic shock and ventricular assist device.

Ventricular assist devices have been shown to be effective in advanced heart failure selected patients. They often have borderline end-organ function, what facilitates organ dysfunction. Liver failure is difficult to manage and leads to increased morbidity and mortality. We report a case of ductular cholestasis, an unusual cholestatic hepatic failure with untractable coagulopathy, developed during the use of a magnetic levitation centrifugal pump, implanted as a bridge to heart transplantation, in a patient with cardiogenic shock (as an end-stage disease of idiopathic dilated cardiomyopathy). We discussed the pathophysiology of this entity and the possible related factors, including the assist device. Preemptive interventions have been advocated as the primary way of treatment. Preoperative optimization of heart function and avoidance of visceral hypoperfusion and sepsis may play a major role.

[Injury pattern in all-terrain vehicle accidents]. / Patrón lesional por accidentes de quad (vehículos todoterreno).

OBJECTIVE: To define the epidemiological and injury profile of patients severely injured due to all-terrain vehicle accidents admitted to the Trauma ICU of a tertiary hospital. METHODS: Descriptive observational study including all patients admitted to our ICU who suffered an all-terrain vehicle accident in the last three years, included prospectively in our data base. We recorded demographic variables, clinical condition at admission, outcome, injury pattern, severity scores and survival probability by TRISS. RESULTS: Between 2004 and 2006 twelve patients who suffered an all-terrain vehicle accident were admitted. All of them were male and had a median age of 28.5 years (18-37.75). The median ISS was 25 points (17-27). Cranium and brain (AIS region 1) were present in 75% of the patients, face (AIS 2) in 41.6%, upper limbs (AIS 7) in 33%, thorax (AIS 4) in 25%, spine (AIS 6) and lower limbs (AIS 8) in 16.7% and there were no injures in AIS region 3 (neck) and 5 (abdomen-pelvis). Mortality at ICU and at day 28 was 16.7% and hospital mortality was 25%. Median ICU stay was 8 days (1.75-17) and median hospital stay was 21.5 days (8.25-27). ICU stay was shorter in patients without traumatic brain injury (1 [1-1.5] vs 12 [5-23]; p < 0.05). CONCLUSIONS: All-terrain vehicle use is a growing source of high morbidity and mortality accidents. Injury patterns associated to these accidents are described. Traumatic brain injuries are common and have a poorer prognosis. New epidemiological and clinical studies are needed for a better knowledge of the problem.

Patrón lesional por accidentes de quad (vehículos todoterreno) / Injury pattern in all-terrain vehicle accidents

Objetivos. Definir el perfil epidemiológico y lesional de los pacientes graves atendidos por accidente de quad en la UCI de traumatología de un hospital terciario de referencia. Métodos. Estudio observacional descriptivo que incluye a todos los pacientes ingresados por accidente de quad en los últimos 3 años, recogidos prospectivamente en la base de datos de nuestra UCI de traumatología. Se registraron variables relativas a datos demográficos, situación al ingreso, evolución, lesiones por regiones corporales, índices de gravedad y probabilidad de supervivencia por TRISS. Resultados. Entre 2004 y 2006 se recibió a 12 pacientes accidentados por quad, todos varones, con una mediana de edad de 28,5 (18-37,75) años. La mediana del ISS fue de 25 (17-27) puntos. En cuanto a las lesiones, el 75% de los pacientes presentaron lesiones craneales y encefálicas (región AIS 1); el 41,6%, faciales (AIS 2); el 33%, en las extremidades superiores (AIS 7); el 25%, torácicas (AIS 4); el 16,7%, raquimedulares (AIS 6) y en extremidades inferiores (AIS 8), y ninguno cervicales y abdominales (AIS 3 y 5). La mortalidad en UCI y a los 28 días alcanzó el 16,7%, y la mortalidad hospitalaria fue del 25%. La mediana de la estancia en UCI fue 8 (1,75-17) días y la estancia hospitalaria fue de 21,5 (8,25-27) días. La estancia en UCI fue menor en los pacientes sin traumatismo craneoencefálico (TCE) que en los pacientes con TCE (1 [1-1,5] frente a 12 [5-23]; p < 0,05). Conclusiones. El uso de quad es una fuente de accidentes con alta morbimortalidad y está en aumento. Se describen los patrones lesionales relaciona-dos con estos accidentes. El TCE es frecuente y empeora el pronóstico. Se necesitan nuevos estudios epidemiológicos y clínicos para definir mejor el problema The increased use of biomaterials for the repair of abdominal wall hernias has achieved a significant reduction in recurrences and consequently improved the quality of life of patients. However, the appearance of complications such as infection may require the implanted prosthetic material to be removed in a considerable number of patients. A possible treatment option in areas compromised by infection is the implant a biocompatible prosthetic material to generate, or induce the formation of a support tissue so that, in a second stage, the definitive repair of the parietal defect may be undertaken. This is the main goal of bioprostheses. These implants are composed of collagen of animal (usually porcine) or human origin. They should be acellular and fully biocompatible so that they induce a minimal foreign body reaction and immune response (AU)

Objective. To define the epidemiological and injury profile of patients severely injured due to all-terrain vehicle accidents admitted to the Trauma ICU of a tertiary hospital. Methods. Descriptive observational study including all patients admitted to our ICU who suffered an all-terrain vehicle accident in the last three years, included prospectively in our data base. We recorded demographic variables, clinical condition at admission, outcome, injury pattern, severity scores and survival probability by TRISS. Results. Between 2004 and 2006 twelve patients who suffered an all-terrain vehicle accident were admitted. All of them were male and had a median age of 28.5 years (18-37.75). The median ISS was 25 points (17-27). Cranium and brain (AIS region 1) were present in 75% of the patients, face (AIS 2) in 41.6%, upper limbs (AIS 7) in 33%, thorax (AIS 4) in 25%, spine (AIS 6) and lower limbs (AIS 8) in 16.7% and there were no injures in AIS region 3 (neck) and 5 (abdomen-pelvis). Mortality at ICU and at day 28 was 16.7% and hospital mortality was 25%. Median ICU stay was 8 days (1.75-17) and median hospital stay was 21.5 days (8.25-27). ICU stay was shorter in patients without traumatic brain injury (1 [1-1.5] vs 12 [5-23]; p < 0.05). Conclusions. All-terrain vehicle use is a growing source of high morbidity and mortality accidents. Injury patterns associated to these accidents are described. Traumatic brain injuries are common and have a poorer prognosis. New epidemiological and clinical studies are needed for a better knowledge of the problem The increased use of biomaterials for the repair of abdominal wall hernias has achieved a significant reduction in recurrences and consequently improved the quality of life of patients. However, the appearance of complications such as infection may require the implanted prosthetic material to be removed in a considerable number of patients. A possible treatment option in areas compromised by infection is the implant a biocompatible prosthetic material to generate, or induce the formation of a support tissue so that, in a second stage, the definitive repair of the parietal defect may be undertaken. This is the main goal of bioprostheses. These implants are composed of collagen of animal (usually porcine) or human origin. They should be acellular and fully biocompatible so that they induce a minimal foreign body reaction and immune response (AU)