Subject(s)
Anus Diseases , Pemphigoid, Benign Mucous Membrane , Humans , Anal Canal , Mucous MembraneSubject(s)
Antiphospholipid Syndrome , Glucocorticoids/administration & dosage , Heparin/administration & dosage , Purpura , Skin , Thrombosis , Antibodies/blood , Anticoagulants/administration & dosage , Antiphospholipid Syndrome/diagnosis , Antiphospholipid Syndrome/immunology , Antiphospholipid Syndrome/physiopathology , Antiphospholipid Syndrome/therapy , Biopsy/methods , Diagnosis, Differential , Female , Humans , Middle Aged , Necrosis , Pruritus/diagnosis , Pruritus/etiology , Purpura/diagnosis , Purpura/etiology , Skin/blood supply , Skin/pathology , Thrombosis/etiology , Thrombosis/pathology , Treatment OutcomeSubject(s)
HIV Infections/immunology , Herpes Simplex/diagnosis , Immune Reconstitution Inflammatory Syndrome/diagnosis , Scrotum/pathology , Skin Ulcer/diagnosis , Administration, Topical , Adult , Antiretroviral Therapy, Highly Active/adverse effects , Antiretroviral Therapy, Highly Active/methods , Antiviral Agents/therapeutic use , Biopsy, Needle , Cidofovir , Cytosine/analogs & derivatives , Cytosine/therapeutic use , Diagnosis, Differential , Follow-Up Studies , HIV Infections/diagnosis , HIV Infections/drug therapy , Herpes Simplex/drug therapy , Herpes Simplex/pathology , Humans , Immune Reconstitution Inflammatory Syndrome/drug therapy , Immunohistochemistry , Male , Organophosphonates/therapeutic use , Scrotum/drug effects , Severity of Illness Index , Skin Ulcer/drug therapy , Skin Ulcer/virology , Treatment Outcome , Wound Healing/drug effects , Wound Healing/physiologyABSTRACT
Melanocytic nevi can have a wide range of histologic appearances. Within the spectrum of nevi, there exists a group that presents in certain anatomic locations with histologically worrisome features but nonetheless benign behavior. This group of nevi has been broadly categorized as nevi of special sites. The anatomic locations affected by this group include the embryonic milkline (breast, axillae, umbilicus, genitalia), flexural areas, acral surfaces, ear, and scalp. Nevi in these locations may be mistaken for melanomas because of their histologic appearance, resulting in inappropriate overtreatment of patients. In this article, the authors review the histologic features of these special site nevi and discuss the criteria that help distinguish them from melanoma.
Subject(s)
Nevus/pathology , Skin Neoplasms/pathology , Ear Neoplasms/diagnosis , Ear Neoplasms/pathology , Humans , Nevus/diagnosis , Skin Neoplasms/diagnosis , Urogenital Neoplasms/diagnosis , Urogenital Neoplasms/pathologySubject(s)
Antiviral Agents/therapeutic use , Facial Dermatoses/pathology , Facial Dermatoses/virology , Immunosuppression Therapy/adverse effects , Kidney Transplantation , Administration, Oral , Administration, Topical , Adult , Antiviral Agents/administration & dosage , Facial Dermatoses/drug therapy , Female , Hair Follicle/pathology , Humans , Intermediate Filament Proteins , Polyomavirus , Protein Precursors/analysisABSTRACT
BACKGROUND: Hailey-Hailey Disease (HHD) is an autosomal dominant skin disorder that is characterized by erythematous and sometimes vesicular, weeping plaques of intertriginous regions. Squamous cell carcinoma and basal cell carcinoma arising in lesions of HHD have been described in the literature. To our knowledge, there are no reports of melanoma or noncutaneous malignant neoplasms associated with HHD. OBSERVATIONS: We discuss the mechanisms of oncogenicity, including genetic, environmental, and iatrogenic factors, in 2 patients with HHD, multiple primary melanomas, and other cancers. Patient 1 had a mucoepidermoid carcinoma of the parotid gland. Patient 2 had a history of acute monoblastic leukemia and malignant peripheral nerve sheath tumor as well as radiologic evidence of an acoustic neurilemmoma. CONCLUSIONS: The cause of the cancers in these 2 patients is likely multifactorial. We describe the patients to draw attention to the possible association between HHD and cancer. Additional research should be performed to determine whether patients with HHD have an increased incidence of cancer.
Subject(s)
Melanoma/pathology , Neoplasms, Multiple Primary/pathology , Pemphigus, Benign Familial/complications , Skin Neoplasms/pathology , Adult , Aged , Carcinoma, Mucoepidermoid/pathology , Humans , Leukemia, Monocytic, Acute/pathology , Male , Nerve Sheath Neoplasms/pathology , Neuroma, Acoustic/pathology , Parotid Neoplasms/pathologyABSTRACT
Hemorrhagic vesicles in a newborn present a challenging differential diagnosis including both infectious and neoplastic disorders. Patients should be evaluated in an efficient manner to arrive at the correct diagnosis as quickly as possible. We present here an interesting case that outlines the methodical workup that ultimately revealed the diagnosis of congenital Langerhans cell histiocytosis. After a diagnosis of Langerhans cell histiocytosis is made, it is important to evaluate the patient thoroughly for systemic involvement. Historically, the diagnosis of congenital self-healing Langerhans cell histiocytosis was used to delineate a benign self-limited disorder limited to the skin with spontaneous resolution during the first several months of life; this disorder may also be referred to as "self-regressive Langerhans cell histiocytosis." However, some newborns with initial skin-only Langerhans cell histiocytosis progress to have multisystem disease after spontaneous resolution has occurred. For this reason, the nomenclature is changing. We suggest using the term "skin-only Langerhans cell histiocytosis." Periodic long-term follow-up is recommended to monitor for relapse or progression to systemic disease.
Subject(s)
Histiocytosis, Langerhans-Cell/diagnosis , Skin Diseases, Vesiculobullous/diagnosis , Diagnosis, Differential , Female , Hemorrhage/complications , Histiocytosis, Langerhans-Cell/complications , Humans , Infant, Newborn , Skin Diseases, Vesiculobullous/complicationsABSTRACT
We present two rare cases of phacomatosis pigmentovascularis type IIb, with one patient demonstrating concurrent Sturge-Weber syndrome and Klippel-Trenaunay syndrome. To the best of our knowledge, this is the second infantile case meeting diagnostic criteria for systemic phacomatosis pigmentovascularis type IIb, Sturge-Weber syndrome and Klippel-Trenaunay syndrome in the English language literature.
Subject(s)
Klippel-Trenaunay-Weber Syndrome/diagnosis , Neurocutaneous Syndromes/diagnosis , Sturge-Weber Syndrome/diagnosis , Vascular Malformations/diagnosis , Humans , Infant , Infant, Newborn , MaleABSTRACT
Sweet syndrome, or acute febrile neutrophilic dermatosis, is characterized by the presence of fever, peripheral leukocytosis, painful erythematous plaques and nodules, and a predominately neutrophilic dermal infiltrate. We report a case occurring in a 10-week-old male child, with preceding upper respiratory tract, and gastrointestinal infection symptoms. Sweet syndrome occurring in an infant should prompt a work-up for immunodeficiency, as well as a review of the peripheral blood smear to rule out the rare case of malignancy.
Subject(s)
Sweet Syndrome/diagnosis , Diarrhea/complications , Fever/diagnosis , Humans , Immunologic Deficiency Syndromes/diagnosis , Infant , Leukocytosis/diagnosis , Male , Neutrophils , Pharyngitis/complications , Sweet Syndrome/etiology , Sweet Syndrome/pathologyABSTRACT
The taxanes, docetaxel and paclitaxel, are microtubule stabilizing chemotherapeutic agents that have demonstrated antineoplastic effects in a variety of solid tumors. They have been linked to the development of localized cutaneous sclerosis in some patients. We present a case of docetaxel-induced cutaneous sclerosis of the lower extremities in a patient with pre-existing CREST syndrome. We propose that patients with a history of limited or diffuse systemic sclerosis should be given taxane chemotherapy with caution, as these patients may have an immunological predisposition for the development of drug-induced morphea.
ABSTRACT
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare serious adverse effect associated with a variety of medications. We present a case of minocycline-induced DRESS syndrome, which resulted in acute renal failure, transient thyroiditis, and transaminitis, and a persistent lymphocytic myocarditis resulting in congestive heart failure. To our knowledge, this is the third reported case of minocycline-induced myocarditis. Additionally, we report successful plasmapheresis and rituximab treatment for minocycline-induced myocarditis associated with the DRESS syndrome.
Subject(s)
Drug Eruptions/etiology , Drug Hypersensitivity/etiology , Eosinophilia/chemically induced , Minocycline/adverse effects , Myocarditis/chemically induced , Acne Vulgaris/drug therapy , Adult , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Murine-Derived , Drug Eruptions/drug therapy , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/drug therapy , Female , Humans , Myocarditis/drug therapy , Plasmapheresis , RituximabABSTRACT
Melanocytic nevi can have a wide range of histologic appearances. Within the spectrum of nevi, there exists a group that presents in certain anatomic locations with histologically worrisome features but nonetheless benign behavior. This group of nevi has been broadly categorized as nevi of special sites. The anatomic locations affected by this group include the embryonic milkline (breast, axillae, umbilicus, genitalia), flexural areas, acral surfaces, ear, and scalp. Nevi in these locations may be mistaken for melanomas because of their histologic appearance, resulting in inappropriate overtreatment of patients. In this article, the authors review the histologic features of these special site nevi and discuss the criteria that help distinguish them from melanoma.
ABSTRACT
Erythema ab igne is a condition characterized by reticulated telangiectasia and hyperpigmentation caused by repeated long-term exposure to infrared radiation insufficient to produce a burn. We report a case of laptop computer-induced erythema ab igne.