A practical entry to ß-aryl-ß-alkyl amino alcohols: application to the synthesis of a potent BACE1 inhibitor.

The 1,2-addition of alkyl Grignard reagents to readily available N-tert-butanesulfinyl ketimines, bearing an α-silyloxy substituent, proceeds in high yields and excellent diastereocontrol. The utility of the present method was demonstrated by the synthesis, in enantiomerically pure form, of one recently disclosed ß-secretase (BACE1) inhibitor.