ABSTRACT
Sarcoidosis is a rare multisystem chronic inflammatory disease in children. We present a case of a five-year-old child with clinical features mimicking several diseases, including tuberculosis. After failure of treatment based on the suspected diagnosis, an axillary lymph node biopsy showed noncaseating granulomas compatible with sarcoidosis and appropriate treatment was then started.
Subject(s)
Sarcoidosis/diagnosis , Anthelmintics/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Biopsy , Brazil , Child, Preschool , Diagnosis, Differential , Female , Humans , Lymphoma/diagnosis , Prednisolone/therapeutic use , Sarcoidosis/drug therapy , Thiabendazole/therapeutic use , Tomography, X-Ray Computed , Tuberculosis/diagnosisABSTRACT
Abstract Sarcoidosis is a rare multisystem chronic inflammatory disease in children. We present a case of a five-year-old child with clinical features mimicking several diseases, including tuberculosis. After failure of treatment based on the suspected diagnosis, an axillary lymph node biopsy showed noncaseating granulomas compatible with sarcoidosis and appropriate treatment was then started.
Subject(s)
Humans , Female , Child, Preschool , Sarcoidosis/diagnosis , Sarcoidosis/drug therapy , Thiabendazole/therapeutic use , Tuberculosis/diagnosis , Biopsy , Brazil , Prednisolone/therapeutic use , Tomography, X-Ray Computed , Diagnosis, Differential , Lymphoma/diagnosis , Anthelmintics/therapeutic use , Anti-Inflammatory Agents/therapeutic useABSTRACT
Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
Subject(s)
Amphotericin B/administration & dosage , Antiprotozoal Agents/administration & dosage , Leishmaniasis, Visceral/drug therapy , Meglumine/administration & dosage , Organometallic Compounds/administration & dosage , Pentamidine/administration & dosage , Drug Therapy, Combination , Humans , Infant , Male , Meglumine AntimoniateABSTRACT
Abstract Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
Subject(s)
Humans , Male , Infant , Organometallic Compounds/administration & dosage , Pentamidine/administration & dosage , Amphotericin B/administration & dosage , Leishmaniasis, Visceral/drug therapy , Meglumine/administration & dosage , Antiprotozoal Agents/administration & dosage , Drug Therapy, Combination , Meglumine AntimoniateABSTRACT
Kodamaea (Pichia) ohmeri is a yeast species that has not been reported to be a frequent cause of human infections. The current report describes a case of fungemia caused by K. ohmeri in a 3-year-old female patient hospitalized in the public hospital Maria Alice Fernandes, Natal, RN, Brazil. The patient had previously received antimicrobial therapy due to a peritoneal infection and nosocomial pneumonia, and had a central venous catheter implanted. Kodamaea ohmeri was isolated from blood and the tip of the catheter, 48 h after its implantation. The yeast was identified by standard microbiological methods and sequence analysis of the D1/D2 domains and the ITS 1 + 2 spacer regions of the ribosomal DNA. On CHROMagar Candida medium, the isolate showed a color change from pink to blue. The yeast was susceptible to amphotericin B, and liposomal AmB was used successfully to clear the infection.