Effects of Digital Physical Activity Interventions for Breast Cancer Patients and Survivors: A Systematic Review and Meta-Analysis.

OBJECTIVES: The benefits of physical activity (PA) for breast cancer (BC) patients and survivors are well documented. With the widespread use of the internet and mobile phones, along with the recent coronavirus disease 2019 pandemic, there has been a growing interest in digital health interventions. This study conducted a systematic review and meta-analysis to evaluate the effects of digital PA interventions for BC patients and survivors in improving PA and quality of life (QoL). METHODS: We searched eight databases, including PubMed, CINAHL, Embase, Scopus, Web of Science, Cochrane Central Register of Controlled Trials in the Cochrane Library, RISS, and DBpia. Studies were included if they provided digital PA interventions, assessed PA and QoL among BC patients and survivors, and were published from inception to December 31, 2022. RESULTS: In total, 18 studies were identified. The meta-analysis showed significant improvement in the total PA duration (five studies; standardized mean difference [SMD] = 0.71; 95% confidence interval [CI], 0.25-1.18; I2 = 86.64%), functional capacity (three studies; SMD = 0.38; 95% CI, 0.10-0.66; I2 = 14.36%), and QoL (nine studies; SMD = 0.45; 95% CI, 0.22-0.69; I2 = 65.55%). CONCLUSIONS: Digital PA interventions for BC patients and survivors may significantly improve PA, functional capacity, and QoL. Future research should focus on the long-term effects of digital PA interventions, using objective outcome measures.

Identifying Nursing Diagnosis Patterns in Three Intensive Care Units Using Network Analysis.

PURPOSE: This study aimed to analyze the patterns of nursing diagnoses used in three different types of intensive care units (ICUs) using network analysis. METHODS: A secondary analysis was conducted using clinical datasets of 582 patients. Frequency, degree/betweenness centrality, and subgroup analysis were performed. FINDINGS AND CONCLUSIONS: The findings illuminated core nursing diagnoses with high centrality as well as high frequency. The centrality analysis identified the differences between and unique characteristics of each ICU. The subgroup analysis revealed the nursing problem groups related to the specific nursing care delivered to ICU patients. IMPLICATIONS FOR NURSING PRACTICE: Theses results provide a knowledge base to aid ICU nurses' prompt decision making regarding nursing diagnoses.

Applying of Decision Tree Analysis to Risk Factors Associated with Pressure Ulcers in Long-Term Care Facilities.

OBJECTIVES: The purpose of this study was to use decision tree analysis to explore the factors associated with pressure ulcers (PUs) among elderly people admitted to Korean long-term care facilities. METHODS: The data were extracted from the 2014 National Inpatient Sample (NIS)-data of Health Insurance Review and Assessment Service (HIRA). A MapReduce-based program was implemented to join and filter 5 tables of the NIS. The outcome predicted by the decision tree model was the prevalence of PUs as defined by the Korean Standard Classification of Disease-7 (KCD-7; code L89*). Using R 3.3.1, a decision tree was generated with the finalized 15,856 cases and 830 variables. RESULTS: The decision tree displayed 15 subgroups with 8 variables showing 0.804 accuracy, 0.820 sensitivity, and 0.787 specificity. The most significant primary predictor of PUs was length of stay less than 0.5 day. Other predictors were the presence of an infectious wound dressing, followed by having diagnoses numbering less than 3.5 and the presence of a simple dressing. Among diagnoses, "injuries to the hip and thigh" was the top predictor ranking 5th overall. Total hospital cost exceeding 2,200,000 Korean won (US $2,000) rounded out the top 7. CONCLUSIONS: These results support previous studies that showed length of stay, comorbidity, and total hospital cost were associated with PUs. Moreover, wound dressings were commonly used to treat PUs. They also show that machine learning, such as a decision tree, could effectively predict PUs using big data.

Utilization and Content Evaluation of Mobile Applications for Pregnancy, Birth, and Child Care.

OBJECTIVES: The purpose of this study was to explore the use of mobile applications about pregnancy, birth, and child care among pregnant women and to review the characteristics, contents, and credibility of the applications used by these women. METHODS: This study was cross-sectional and was conducted using a survey method. One hundred and ninety-three pregnant women participated in this study. The questionnaire was developed to examine the pattern and reasons for pregnancy-related application usage. The 47 mobile apps used by participants were reviewed and categorized based on functions and developers. The credibility of the information provided by the mobile applications was evaluated using a structured measurement. RESULTS: Fifty-five percent of the participants were using mobile apps related to pregnancy, birth, and/or child care. First-time mothers used the apps significantly more often than women who were pregnant for the second time. Women who had used a smartphone for a longer period of time were more likely to use apps related to pregnancy, birth, and/or child care. The most frequently-used information concerned signs of risk and disease during pregnancy. Experts' quick opinions and Q&A formats related to diet and medication administration during pregnancy were the women's most cited need for content in applications. Information was the most common function of the apps. In the evaluation of information credibility, the 'information source' category had the lowest score. CONCLUSIONS: The results showed that applications related to pregnancy, birth, and child care have become an important information source for pregnant women. To fulfill the needs of users, credible applications related to pregnancy, birth, and child care should be developed and managed by qualified healthcare professionals.

Complete genome sequence of Celeribacter marinus IMCC12053(T), the host strain of marine bacteriophage P12053L.

Isolated from coastal seawater from Yellow Sea of Korea, Celeribacter marinus IMCC12053 was used as the host bacterium for bacteriophage P12053L. Here we report the complete genome sequence of strain IMCC12053 for further study of the marine bacteriophage P12053L functional genes. Single molecule real-time technology (PacBio RSII) was used for the single circular chromosome that is 3,096,705 base pairs in length and the GC content is 56.24%. It contains 3155 ORFs with 45 tRNAs and 6 rRNAs genes. N(6)-methyladenosine patterns were also investigated for 32 unmethylated genes and intergenic regions that covered many regulators and phage genes as well as ribosomal RNA genes and tRNA genes. Cryptic N(4)-methylcytosine pattern was investigated to speculate GpC methylase activity throughout the genome. Comparative genomics with other Celeribacter genomes were carried out for polyaromatic hydrocarbon degradation, but there were no aromatic ring oxygenases in IMCC12053 when compared to Celeribacter indicus P73.

Association of eHealth literacy with cancer information seeking and prior experience with cancer screening.

Cancer is a critical disease with a high mortality rate in the US. Although useful information exists on the Internet, many people experience difficulty finding information about cancer prevention because they have limited eHealth literacy. This study aimed to identify relationships between the level of eHealth literacy and cancer information seeking experience or prior experience with cancer screening tests. A total of 108 adults participated in this study through questionnaires. Data covering demographics, eHealth literacy, cancer information seeking experience, educational needs for cancer information searching, and previous cancer screening tests were obtained. Study findings show that the level of eHealth literacy influences cancer information seeking. Individuals with low eHealth literacy are likely to be less confident about finding cancer information. In addition, people who have a low level of eHealth literacy need more education about seeking information than do those with a higher level of eHealth literacy. However, there is no significant relationship between eHealth literacy and cancer screening tests. More people today are using the Internet for access to information to maintain good health. It is therefore critical to educate those with low eHealth literacy so they can better self-manage their health.

Physical activity in police beyond self-report.

OBJECTIVE: Police officers have a higher risk for cardiovascular disease. Reductions in occupational physical activity may contribute to the risk, yet there have been few efforts to characterize the physical demands of police work beyond self-report. PURPOSE: To compare measured physical activity between work and off-duty hours and assess the effects of stress on physical activity. METHODS: Officers (n = 119) from six departments wore a pattern recognition monitor for 96 hours to measure total energy expenditure (kilocalorie per hour) (1k/cal = 4184 joules), activity intensity, and step count per hour. RESULTS: Participants were more active on their off-duty days than at work; the effects of stress on physical activity seemed moderated by sex. CONCLUSIONS: Police work is primarily a sedentary occupation, and officers tend to be more active on their off-duty days than during their work hours.

Korean nursing students' intention to migrate abroad.

BACKGROUND: Migration of Korean nurses has continued with changing patterns and reasons. However, detailed studies of migration among Korean nursing students are limited. OBJECTIVES: This study examined the intention, reasons, and preferences of migration among Korean nursing students. This study also identified priorities and barriers to the decision of nursing students to migrate and work abroad. DESIGN: A descriptive study using a questionnaire was used for this study. PARTICIPANTS AND SETTINGS: A total of 717 nursing students from four BSN programs and three diploma programs at nursing schools in D city and K province of South Korea were included in the analysis. RESULTS: According to the results, 69.8% of respondents intended to migrate abroad, if possible, or absolutely in the future. The score for females who answered "yes, if possible" regarding the intention to migrate was significantly higher, compared to males. More than 64% of respondents eventually want to return to Korea after migration. The two most common reasons for migration were economic reason (salary) (29.7%) and "professional development (28.2%)". Half of all respondents preferred the US as the destination country of migration (50.5%). "Working condition" was the most prevalent reason for the decision regarding the destination and the place to work. More than 71% of respondents selected "the lack of language proficiency" as a barrier to migration. CONCLUSIONS: Economic reason was not as strong as in the past to explain migration of Korean nursing students. Most Korean nursing students want to return back with professional development and higher degree. Even permanent migration and return migration of nurses are an inevitable part of globalization, positive and negative aspects of migration between donor as well as destination countries should be investigated.

The effect of work shift and sleep duration on various aspects of police officers' health.

Police officers are prone to cardiovascular disease, overweight, and obesity. Because night-shift work affects sleep, a modifiable risk factor linked to chronic disease, the researchers explored the relationship among shift work, sleep, and wellness for police officers. Sleep, C-reactive protein (CRP) levels, stress, fatigue, and body mass index were used to compare officers who worked primarily day shifts to those who worked primarily evening or night shifts, and officers who slept less than 6 hours per day to those who slept at least 6 hours per day. A cross-sectional study of 85 male officers, 20 to 63 years old, was completed at three Midwestern police departments. The Pittsburgh Sleep Quality Index was used to assess sleep. A questionnaire was used to collect officer demographics and work hours. Other measurements included serum CRP, height, weight, perceived stress, and vital exhaustion. The relative risk of sleeping less than 6 hours per day for officers who primarily worked non-day shifts, compared to those who worked day shifts, was 14.27 (95% confidence interval [CI], 1.98-102.95, p < .001), and the relative risk of overall poor sleep quality for officers who slept less than 6 hours per day, compared to those who slept more hours, was 2.44 (95% CI, 1.15-5.20, p = .027). CRP was not associated with shift or sleep duration, even when adjusted for officers' ages.

Clinical features and outcomes of 98 children and adults with dense deposit disease.

BACKGROUND: Dense deposit disease (DDD) is an ultra-rare renal disease. METHODS: In the study reported here, 98 patients and their families participated in a descriptive patient-centered survey using an online research format. Reports were completed by patients (38%) or their parents (62%). Age at diagnosis ranged from 1.9 to 38.9 years (mean 14 years). RESULTS: The majority of patients presented with proteinuria and hematuria; 50% had hypertension and edema. Steroids were commonly prescribed, although their use was not evidence-based. One-half of the patients with DDD for 10 years progressed to end-stage renal disease (ESRD), with young females having the greatest risk for renal failure. Of first allografts, 45% failed within 5 years, most frequently due to recurrent disease (70%). Type 1 diabetes (T1D) was present in over 16% of families, which represents a 116-fold increase in incidence compared with the general population (p < 0.001). CONCLUSIONS: Based on these findings, we suggest that initiatives are needed to explore the high incidence of T1D in family members of DDD patients and the greater risk for progression to ESRD in young females with DDD. These efforts must be supported by sufficient numbers of patients to establish evidence-based practice guidelines for disease management. An international collaborative research survey should be implemented to encourage broad access and participation.

Pentoxifylline protects L929 fibroblasts from TNF-alpha toxicity via the induction of heme oxygenase-1.

Tumor necrosis factor-alpha (TNF-alpha) is recognized as a principal mediator of a variety of inflammatory conditions. Pentoxifylline (PTX), which can inhibit cellular TNF-alpha synthesis, also attenuates the toxic effect of TNF-alpha. However, the mechanism underlying PTX-induced cytoprotection is unknown. Heme oxygenase 1 (HO-1) is an enzyme which degrades heme into biliverdin, free iron, and carbon monoxide (CO). This enzyme has recently been shown to have anti-inflammatory and cytoprotective effects. In this study, we investigated whether protection by PTX against TNF-alpha-mediated toxicity could be related to its ability to induce HO-1 expression and HO activity in L929 cells. PTX in the range of 0.1-1.0mM significantly induced HO-1 expression and the resulting HO activity. Pre-incubation of L929 cells with either PTX or the HO activator hemin resulted in the protection of the cells against TNF-alpha-mediated toxicity. Zinc protoporphyrin, a specific HO competitive inhibitor, abrogated the protective effect of PTX. Hemoglobin, a scavenger of CO, reversed the protective effect of PTX. A cytoprotection comparable to PTX was observed when the cells were treated with the CO-releasing compound tricarbonyldichlororuthenium(II) dimer. These results suggest that HO-1 expression and the ensuing formation of the HO metabolite CO may be a novel pathway by which PTX protects L929 cells from TNF-alpha-mediated toxicity.