ABSTRACT
BACKGROUND: Cancer-therapy-related cardiac dysfunction (CTRCD) is a growing concern for public health, with a growing incidence due to improved survival rates of patients with hematological malignancies due to diagnostic and therapeutic advances. The identification of patients at risk for CTRCD is vital to developing preventive strategies. METHODS: A single-center retrospective cohort study was conducted between 1 January 2017 and 15 February 2023. Medical records of patients with lymphoma treated with first-line anthracyclines were reviewed. Demographic data, cardiovascular risk factors, biomarkers of myocardial damage, and echocardiographic information were collected. RESULTS: A total of 200 patients were included. The incidence of CTRCD was 17.4% (35/200). Patients with CTRCD were older than those without CTRCD, with a mean age of 65.17 years vs. 56.77 (p = 0.008). Dyslipidemia (DL) (31.4% vs. 13.4% p = 0.017) and previous cardiovascular disease (40% vs. 13.3%; p < 0.001) were more frequent in the group who developed an event. Mean baseline NT-proBNP levels in the subgroup with cardiovascular events were 388.73 kg/L ± 101.02, and they were 251.518 kg/L ± 26.22 in those who did not (p = 0.004). Differences in Troponin I levels were identified during and after treatment without exceeding the laboratory's upper reference limit. Patients were followed for a median of 51.83 months (0.76-73.49). The presence of a CTCRD event had a negative impact on overall mortality from any cause (HR = 2.23 (95% CI: 1.08-2.93); p = 0.031). CONCLUSIONS: Early identification of risk factors is crucial to manage patients at risk for CTRCD.
Subject(s)
Anthracyclines , Cardiovascular Diseases , Lymphoma , Humans , Anthracyclines/adverse effects , Anthracyclines/therapeutic use , Male , Female , Aged , Middle Aged , Retrospective Studies , Cardiovascular Diseases/chemically induced , Lymphoma/drug therapy , Risk Factors , Cardiotoxicity , IncidenceABSTRACT
FUNDAMENTOS: Un estilo de vida saludable está relacionado con la salud física y mental. El objetivo de este trabajo fue evaluar si diferentes comportamientos de estilo de vida saludable estaban asociados con el bienestar subjetivo. MÉTODOS: Se entrevistó a un total de 10.800 participantes de Finlandia, Polonia y España en 2011-2012. La actividad física, el consumo de frutas y verduras, el tabaco, el alcohol y la calidad del sueño fueron autoinformados. La satisfacción con la vida se midió con la Cantril Self-Anchoring Striving Scale. El afecto positivo y negativo se evaluaron utilizando una versión abreviada del Método de Reconstrucción del Día. Se llevaron a cabo análisis de regresión múltiple. RESULTADOS: Las conductas de estilo de vida saludable (consumo de cinco o más frutas y verduras al día, actividad física moderada o alta, no fumar a diario y tener una buena calidad del sueño) se asociaron positivamente con el bienestar evaluativo (ß=0,23,p<0,001; ß=0,16, p<0,001; ß=0,26, p<0,001; ß=0,23, p<0,001, respectivamente), después de controlar por variables de confusión comola salud y la depresión. La buena calidad del sueño se relacionó con mayor afecto positivo (ß=0,29, p<0,001), menor afecto negativo (ß=-0,15, p<0,001) y mayor satisfacción con la vida (ß=0,23, p<0,001), después de ajustar por dichas variables de confusión. CONCLUSIONES: Un estilo de vida saludable se correlaciona de manera importante con el bienestar, independientemente de sus efectos en la salud. Los estilos de vida saludables podrían ser considerados a la hora de desarrollar estrategias que mejoren no solo la salud física, sino también el bienestar de la población.(AU)
BACKGROUND:A h ealthy lifestyle is related to physical and mental health. The aim of this study was to assess whether different healthy lifestyle behaviours are associated with experiential and evaluative well-being. METHODS: A total of 10,800 participants from Finland, Poland and Spain were interviewed in 2011-2012. Physical activity, fruit and vegetable consumption, smoking, alcohol use, and sleep quality were selfeported. Life satisfaction was measured with the Cantril Self-Anchoring Striving Scale. Positive and negative affect were assessed using an abbreviated version of the Day Reconstruction Method. Multivariate regression analyses were performed. RESULTS: Healthy lifestyle behaviours (consumption of five or more servings of fruit and vegetables per day, moderate or high physical activity, being a non-daily smoker, and having a good sleep quality) were positively associated with evaluative well-being (ß=0.23 p<0.001; ß=0.16, p<0.001; ß=0.26, p<0.001; ß=0.23, p<0.001, respectively), after controlling for confounding variables such as health and depression. Good sleep quality was related with higher positive affect (ß=0.29, p<0.001), lower negative affect (ß=-0.15, p<0.001) and higher life satisfaction (ß=0.23, p<0.001), after adjusting for those confounding variables. CONCLUSIONS: A healthy lifestyle is an important correlate of well-being independently of its effects on health. Healthy lifestyles could be considered when developing strategies to improve not only the physical health, but also the well-being of the population.(AU)
Subject(s)
Humans , Male , Female , Healthy Lifestyle , Social Welfare , Mental Health , Motor Activity , Fruit , Vegetables , Personal Satisfaction , Tobacco Use , Finland , Poland , Spain , Public Health , Cross-Sectional Studies , Surveys and QuestionnairesABSTRACT
Multidimensional forced-choice questionnaires are widely regarded in the personnel selection literature for their ability to control response biases. Recently developed IRT models usually rely on the assumption that item parameters remain invariant when they are paired in forced-choice blocks, without giving it much consideration. This study aims to test this assumption empirically on the MUPP-2PL model, comparing the parameter estimates of the forced-choice format to their graded-scale equivalent on a Big Five personality instrument. The assumption was found to hold reasonably well, especially for the discrimination parameters. In the cases in which it was violated, we briefly discuss the likely factors that may lead to non-invariance. We conclude discussing the practical implications of the results and providing a few guidelines for the design of forced-choice questionnaires based on the invariance assumption
Los cuestionarios de elección forzosa multidimensionales son bastante apreciados en la literatura de selección de personal por su capacidad para controlar los sesgos de respuesta. Los modelos de TRI desarrollados recientemente normalmente asumen que los parámetros de los ítems permanecen invariantes cuando se emparejan en bloques de elección forzosa, sin dedicarle mucha atención. Este estudio tiene como objetivo poner a prueba empíricamente este supuesto en el modelo MUPP-2PL, comparando las estimaciones de los parámetros del formato de elección forzosa con su equivalente en escala graduada, en un instrumento de personalidad Big Five. Se encontró que el supuesto se cumplía razonablemente bien, especialmente para los parámetros de discriminación. En los casos en los que no se cumplió se discuten brevemente los posibles factores que pueden dar lugar a no invarianza. Concluimos discutiendo las implicaciones prácticas de los resultados y proponiendo algunas pautas para el diseño de cuestionarios de elección forzosa basados en el supuesto de invarianza
Subject(s)
Humans , Personnel Selection/methods , Professional Competence , Psychometrics/methods , Test Taking Skills/psychology , Job Description , Self Efficacy , Data Interpretation, Statistical , Choice Behavior , Psychological Tests/statistics & numerical dataABSTRACT
BACKGROUND: Forced-choice tests (FCTs) were proposed to minimize response biases associated with Likert format items. It remains unclear whether scores based on traditional methods for scoring FCTs are appropriate for between-subjects comparisons. Recently, Hontangas et al. (2015) explored the extent to which traditional scoring of FCTs relates to the true scores and IRT estimates. The authors found certain conditions under which traditional scores (TS) can be used with FCTs when the underlying IRT model was an unfolding model. In this study, we examine to what extent the results are preserved when the underlying process becomes a dominance model. METHOD: The independent variables analyzed in a simulation study are: forced-choice format, number of blocks, discrimination of items, polarity of items, variability of intra-block difficulty, range of difficulty, and correlation between dimensions. RESULTS: A similar pattern of results was observed for both models; however, correlations between TS and true thetas are higher and the differences between TS and IRT estimates are less discrepant when a dominance model involved. CONCLUSIONS: A dominance model produces a linear relationship between TS and true scores, and the subjects with extreme thetas are better measured
ANTECEDENTES: los tests de elección forzosa (TEFs) fueron propuestos para reducir los sesgos de respuesta de ítems tipo Likert. Se cuestiona que los métodos de puntuación tradicional (PT) empleados permitan hacer comparaciones entre-sujetos. Recientemente, Hontangas et al. (2015) exploraron cómo las PTs obtenidas con diferentes TEFs se relacionan con sus puntuaciones verdaderas y estimaciones TRI, mostrando las condiciones para ser utilizadas cuando el modelo subyacente es un modelo de unfolding. El objetivo del trabajo actual es comprobar si el patrón de resultados se mantiene con un modelo de dominancia. MÉTODO: las variables independientes del estudio de simulación fueron: formato de elección forzosa, número de bloques, discriminación de los ítems, polaridad de los ítems, variabilidad de la dificultad intrabloque, rango de dificultad del test y correlación entre dimensiones. RESULTADOS: un patrón similar de resultados fue obtenido en ambos modelos, pero en el modelo de dominancia las correlaciones entre PTs y puntuaciones verdaderas son más altas y las diferencias entre PTs y estimaciones TRI se reducen. CONCLUSIONES: un modelo de dominancia produce una relación lineal entre PTs y puntuaciones verdaderas, y los sujetos con puntuaciones extremas son medidos mejor