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Angew Chem Int Ed Engl
; 50(52): 12586-90, 2011 Dec 23.
Article
in English
| MEDLINE
| ID: mdl-22038642
ABSTRACT
Syn-gled out: The syn diastereo- and enantioselective addition of azlactones to 3-vinylindoles was accomplished by using a chiral, binapthol-derived, Brønsted acid catalyst (see scheme). This method enables facile access to tryptophan derivatives with adjacent quaternary and tertiary stereogenic centers, which are potentially useful for the synthesis of peptidomimetics.