1.
J Org Chem
; 83(22): 14181-14194, 2018 11 16.
Article
in English
| MEDLINE
| ID: mdl-30358402
ABSTRACT
A novel palladium-catalyzed cascade carbopalladation/phenol dearomatization reaction has been achieved. The process provides a variety of indolone-, dihydrobenzofuran-, dihydrobenzopyran- and hydroquinoline-containing spirofused molecules bearing two quaternary centers in moderate to good yields. The potential synthetic utility of this method is demonstrated by a gram-scale experiment and further transformations.