1.
Org Lett
; 17(9): 2126-9, 2015 May 01.
Article
in English
| MEDLINE
| ID: mdl-25885017
ABSTRACT
Cyclization of 1,6-diynes promoted by stoichiometric Ga(III) halides produces vinyl halides in good to excellent yields. Under acidic conditions, initially formed iodocyclization products undergo in situ Friedel-Crafts cyclizations, giving access to iodoindenopyridines. Application of the vinyl halides in cross-coupling reactions has been explored, and mechanistic aspects of the cyclization are discussed.