ABSTRACT
BACKGROUND AND AIMS: The objective of this study was to investigate the effect of Boswellia serrata extract (BSE) on symptoms, quality of life, and histology in patients with collagenous colitis. MATERIALS AND METHODS: Patients with chronic diarrhea and histologically proven collagenous colitis were randomized to receive either oral BSE 400 mg three times daily for 6 weeks or placebo. Complete colonoscopy and histology were performed before and after treatment. Clinical symptoms and quality of life were assessed by standardized questionnaires and SF-36. The primary endpoint was the percentage of patients with clinical remission after 6 weeks (stool frequencySubject(s)
Anti-Inflammatory Agents/therapeutic use
, Boswellia
, Colitis, Collagenous/drug therapy
, Colon/drug effects
, Diarrhea/etiology
, Gastrointestinal Agents/therapeutic use
, Plant Extracts/therapeutic use
, Administration, Oral
, Aged
, Anti-Inflammatory Agents/administration & dosage
, Anti-Inflammatory Agents/adverse effects
, Chronic Disease
, Colitis, Collagenous/complications
, Colitis, Collagenous/pathology
, Colon/pathology
, Diarrhea/drug therapy
, Diarrhea/pathology
, Double-Blind Method
, Female
, Gastrointestinal Agents/administration & dosage
, Gastrointestinal Agents/adverse effects
, Germany
, Humans
, Male
, Middle Aged
, Patient Compliance
, Plant Extracts/administration & dosage
, Plant Extracts/adverse effects
, Quality of Life
, Surveys and Questionnaires
, Time Factors
, Treatment Outcome